A5100645369- Electrocatalysts for Energy Conversion
- Immune cells in cancer
- Advanced battery technologies research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Advanced Photocatalysis Techniques
- Gas Sensing Nanomaterials and Sensors
- Inflammation biomarkers and pathways
- CO2 Reduction Techniques and Catalysts
- Retinal Development and Disorders
- Immune Cell Function and Interaction
- Inflammasome and immune disorders
- Retinal and Optic Conditions
- Genomic variations and chromosomal abnormalities
- Carbon Nanotubes in Composites
- MXene and MAX Phase Materials
- Electrochemical Analysis and Applications
- ZnO doping and properties
- Advanced biosensing and bioanalysis techniques
- Complement system in diseases
- Sphingolipid Metabolism and Signaling
- Retinal Diseases and Treatments
- Bioenergy crop production and management
- TGF-β signaling in diseases
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Phagocytosis and Immune Regulation
Hefei University of Technology
2025
Nanjing Medical University
2021-2024
Tongji Hospital
2022-2024
Huazhong University of Science and Technology
2022-2024
Sichuan Agricultural University
2023-2024
Jiangsu Province Hospital
2021-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Affiliated Eye Hospital of Wenzhou Medical College
2017-2023
Wenzhou Medical University
2017-2023
Jilin University
2008-2023
Covalent adaptable networks (CANs), which can reconfigure on-demand under photo- or thermal stimuli, have recently been pursued as an alternative to the traditional thermosetting polymers. While these materials demonstrated excellent recyclability and reprocessability, majority of them reported date are based on non-renewable resources. Meanwhile, material recycling highly counts collection system, any that inevitably escape from system will eventually go environment, challenging nature's...
Atomic edge sites on two-dimensional (2D) nanomaterials display striking catalytic behavior, whereas engineering for 2D metal nanocatalysts remains an insurmountable challenge. Here we advance a one-pot synthesis of ultrathin PdPtCu trimetallic nanosheets and nanorings with escalating low-coordinated proportions from 11.74% 23.11% to 45.85% as cutting-edge ethanol oxidation reaction (EOR) electrocatalysts. This in situ enrichment hinges competitive surface capping etching strategy integrated...
Significance Because preschool children encounter fewer risks from environmental pressures, we propose that the condition of early-onset high myopia (EOHM) is driven by a genetic predisposition more than factors. In this study, recruited 18 familial trios to decipher using whole-exome sequencing. We identified cluster unique genes linked EOHM, as well mutations in reported genes. Notably, showed both rare inherited and de novo significantly contributed EOHM. Expression profiling ocular...
N-heterocycle compounds are the crucial scaffolds present in natural products, synthetic molecules, agricultural chemicals, and pharmaceuticals. Hence, development of green catalytic systems for constructing N-heterocycles has been a focused topic organic synthesis industrial catalysis. Polyoxometalates (POMs) polynuclear metal–oxygen clusters with structural diversity physicochemical properties. POMs possess advantageous properties such as adjustable acidity, redox properties, high thermal...
The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) is increasing year by and has become one the leading causes end-stage worldwide. Triggering Receptor Expressed on Myeloid Cells 2 (Trem2) been confirmed to play an essential role in progression MASLD, but its specific mechanism still needs be clarified. This study aims explore Trem2 MASLD.
Abstract A mild, practical and environmentally friendly strategy to prepare β‐amidovinyl sulfones has been developed based on the sulfonation of enamides or enecarbamates via visible‐light photoredox catalysis. Direct CH functionalizations under optimized conditions proceeded with a wide scope substrates remarkable selectivity give functionalized vinyl good excellent yields.
Abstract Background Demyelinating diseases in central nervous system (CNS) are a group of characterized by myelin damage or loss. Transforming growth factor beta1 (TGF-β1) is widely recognized as an anti-inflammatory cytokine, which can be produced both glial and neuronal cells CNS. However, the effects TGF-β1 on demyelinating its underlying mechanisms have not been well investigated. Methods A mouse model using two-point injection lysophosphatidylcholine (LPC) to corpus callosum vivo was...
Abstract Background Liver metastasis is the leading cause of death in patients with colorectal cancer (CRC). Surgical resection liver metastases increases incidence long-term survival (CRLM). However, many experience CRLM recurrence after initial resection. As an unavoidable pathophysiological process surgery, ischemia-reperfusion (IR) injury risk tumor and metastasis. Methods Colorectal (CRLM) mouse models partial warm ischemia were constructed. The levels lipid peroxidation detected cells...
Concavity-tunable Rh@Pt core–shell nanocubes with an engineered Rh–Pt interface and Pt atomic steps facilitate C–C bond cleavage in the EOR.
Abstract In central nervous system (CNS), demyelination is a pathological process featured with loss of myelin sheaths around axons, which responsible for the diseases multiple sclerosis, neuromyelitis optica, and so on. Transforming growth factor‐beta1 (TGF‐β1) multifunctional cytokine participating in abundant physiological processes CNS. However, effects TGF‐β1 on CNS demyelinating disease its underlying mechanisms are controversial not well understood. Herein, we evaluated protective...
Objective Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory demyelinating disease that leads to severe disability. A large proportion of NMOSD patients are seropositive for aquaporin‐4 autoantibodies (AQP4‐IgG, named as NMO‐IgG) targeting AQP4, which selectively expressed on astrocytes in the central nervous system. This study tests hypothesis response NMO‐IgG, pathogenic astrocyte‐derived exosomes released and injure neighboring cells. Methods IgG purified from serum either...
Liver fibrosis is a danger signal indicating huge risk of liver cancer occurrence, but there still no effective clinical means to regulate the progress fibrosis. Although variety drugs targeting SYK have been developed for tumors and autoimmune diseases, mechanism specific efficacy SYK's role in are not yet clear. Our studies based on chronic CCL4, bile duct ligation, subacute TAA mouse models show that monocyte-derived macrophages (MoMFs) fully dependent phosphorylation Erk up-regulate...
Human multiple synostoses syndrome (SYNS) is an autosomal dominant disorder characterized by joint fusions. We previously identified a point mutation (S99N) in FGF9 that causes human SYNS3. However, the physiological function of during development and comprehensive molecular portraits SYNS3 remain elusive. Here, we report mice harboring S99N Fgf9 develop curly tail phenotype partially or fully fused caudal vertebrae limb joints, which mimic major phenotypes patients. Further study reveals...
Cancer is a frequent disease that seriously harms human health, but there are no ideal therapies for it. Currently, some food-grade microorganisms such as Lactobacillus plantarum have shown better anti-tumor effects. Here, recombinant lives vector vaccine NC8-sHSP was generated by using the invasive NC8 expressing FnBPA to deliver associated antigen gene sHSP between trichinella spiralis and Lewis lung cancer cells (LLC) host cells. colonized mouse intestine plasmids intestinal epithelial...
Ternary PtCoRh spiral nanowires with surface atomic steps and anti-corrosive Rh incorporation can serve as active robust MOR electrocatalysts in acidic media.
Abstract Precursor messenger RNA (Pre-mRNA) splicing is an essential biological process in eukaryotic cells. Genetic mutations many spliceosome genes confer human eye diseases. Mutations the pre-mRNA factor, RP9 (also known as PAP1), predispose autosomal dominant retinitis pigmentosa (adRP) with early onset and severe vision loss. However, underlying molecular mechanisms of mutation causing photoreceptor degeneration remains fully unknown. Here, we utilize CRISPR/Cas9 system to generate both...
Ag NPs loaded on macroporous resin with conjugated side-chains can absorb broad wavelength light, transfer electrons to and immobilize “Ag” by amino groups, all of which facilitate the photocatalytic activity stability for 4-NP reduction.
Abstract Chemotherapy-induced peripheral neuropathic pain aggravates cancer survivors' life burden. Electroacupuncture (EA) has exhibited promising analgesic effects on in previous studies. We investigated whether EA was effective a paclitaxel-induced mouse model. further explored the functional role of astrocytes rostral ventromedial medulla (RVM), well-established modulation center, process as well effect EA. found that paclitaxel induced mechanical allodynia, astrocytic calcium signaling,...
Transgenic mouse model with fluorescently labeled sperm has extensive application value. It is an auxiliary tool for investigating the mechanism of fertilization, especially visualizing oviduct-migrating ability in vivo. Here, we produced transgenic lines whose were tagged enhanced green fluorescent protein (EGFP) according to previously described method. Polymerase chain reaction analysis tail-tip genomic DNA identified 13 founders, which 5 male founders offspring form lines. We showed that...
Ultrasmall two-dimensional Pd<sub>55</sub>Pt<sub>18</sub>Co<sub>27</sub> trimetallic alloy nanorings with enriched low-coordinated edge sites exhibit greatly enhanced ORR electrocatalytic activity.
Abstract Background Weeds are not only economically important but also fascinating models for studying the adaptation of species in human-mediated environments. Aegilops tauschii is D-genome donor common wheat a weed that influences production. How shading stress caused by adjacent plants affects Ae. growth fundamental scientific question agriculture, such as control and breeding. Result The present study indicated shade avoidance strategy response to stress. exhibited increases specific...