A5100762512- Neuroinflammation and Neurodegeneration Mechanisms
- Microwave Engineering and Waveguides
- Neuroscience and Neuropharmacology Research
- Acute Ischemic Stroke Management
- Neurogenesis and neuroplasticity mechanisms
- Spinal Cord Injury Research
- Multilevel Inverters and Converters
- Advanced DC-DC Converters
- Neurological Disease Mechanisms and Treatments
- Nerve injury and regeneration
- Cancer-related Molecular Pathways
- Cerebrovascular and Carotid Artery Diseases
- MicroRNA in disease regulation
- Signaling Pathways in Disease
- Wireless Power Transfer Systems
- Advanced Antenna and Metasurface Technologies
- Antenna Design and Analysis
- Electromagnetic Simulation and Numerical Methods
- Advanced Thermoelectric Materials and Devices
- Cerebral Venous Sinus Thrombosis
- Axon Guidance and Neuronal Signaling
- Microgrid Control and Optimization
- Ion channel regulation and function
- Obstructive Sleep Apnea Research
- Dementia and Cognitive Impairment Research
Huazhong University of Science and Technology
2016-2025
Tongji Hospital
2016-2025
Pennsylvania State University
2024
Harbin Institute of Technology
2024
Tongji University
2023
China University of Mining and Technology
2023
Nanjing University of Aeronautics and Astronautics
2017-2020
Fudan University
2020
Beijing Jingshida Electromechanical Equipment Research Institute
2019
Irvine Valley College
2018
Emerging evidence indicates that reactive microglia-initiated inflammatory responses are responsible for secondary damage after primary traumatic spinal cord injury (SCI); epidermal growth factor receptor (EGFR) signaling may be involved in cell activation. In this report, we investigate the influence of EGFR inhibition on microglia activation, proinflammatory cytokine production, and neuronal microenvironment SCI. Lipopolysaccharide-treated microglia/BV2 line cells SCI rats were used as...
Abstract Aims The involvement of pyroptosis in ischemic stroke remains to be established. Therefore, we used the specific inhibitor Vx765 as an experimental intervention target a murine model stroke. Methods A total 564 C57BL/6 mice were subjected photothrombotic procedures and treated via gavage with at 1‐hour post‐ischemia. We subsequently assessed expression Gasdermin D (GSDMD), inflammasomes, caspase‐1, interleukin‐1β (IL‐1β) using immunofluorescence (IF) Western blot (WB) analyses. also...
Abstract Background Immediately after spinal trauma, immune cells, and proinflammatory cytokines infiltrate the cord disrupt focal microenvironment, which impedes axon regeneration functional recovery. Previous studies have reported that regulatory T cells (Tregs) enter central nervous system exert immunosuppressive effects on microglia during multiple sclerosis stroke. However, whether how Tregs interact with modulate injured microenvironments injury (SCI) remains unknown. Method Regulatory...
Abstract Astrogliosis occurs in a variety of neuropathological disorders and injuries, excessive astrogliosis can be devastating to the recovery neuronal function. In this study, we asked whether reactive suppressed lesion area by cell cycle inhibition thus have therapeutic benefits. Reactive induced either cultured astrocytes hypoxia or scratch injury, middle cerebral artery occlusion (MCAO) ischemia model were combined address issue. astrocytes, activation that was associated with...
Tamoxifen has been found to be neuroprotective in both transient and permanent experimental ischemic stroke. However, it remains unknown whether this agent shows a similar beneficial effect after spinal cord injury (SCI), what are its underlying mechanisms. In study, we investigated the efficacy of tamoxifen treatment attenuating SCI-induced pathology. Blood-spinal barrier (BSCB) permeability, tissue edema formation, microglial activation, neuronal cell death myelin loss were determined rats...
Spinal cord injury (SCI) causes neurological dysfunction with devastating consequences. SCI pathogenesis is accompanied by inflammasome activation and neuronal damage. But the spatial pattern time course of pyroptosis apoptosis after should be further elucidated. The microglial voltage-gated proton channel (Hv1) implicated in reactive oxygen species (ROS)-induced damage following ischemic stroke. However, there a lack quantification on associated Hv1 SCI. We analyzed temporal characteristics...
Abstract Background Demyelinating diseases in central nervous system (CNS) are a group of characterized by myelin damage or loss. Transforming growth factor beta1 (TGF-β1) is widely recognized as an anti-inflammatory cytokine, which can be produced both glial and neuronal cells CNS. However, the effects TGF-β1 on demyelinating its underlying mechanisms have not been well investigated. Methods A mouse model using two-point injection lysophosphatidylcholine (LPC) to corpus callosum vivo was...
Abstract It is well established that axons of the adult mammalian CNS are capable regrowing only a limited amount after injury. Astrocytes believed to play crucial role in failure regenerate, producing multiple inhibitory proteoglycans, such as chondroitin sulphate proteoglycans (CSPGs). After spinal cord injury (SCI), astrocytes become hypertrophic and proliferative form dense network astroglial processes at site lesion constituting physical biochemical barrier. Down‐regulations...
Most patients with stroke caused by middle cerebral artery occlusion (MCAO) show cognitive deficit that is generally regarded as resulting from damage to the cortex rather than hippocampus. Whether MCAO induces hippocampal and whether this contributes defects remains unclear. Here we investigate its correlation after exclusively unilateral underlying mechanism for damage.Patients were assessed magnetic resonance imaging (MRI) angiography (MRA), Mini Mental-Status Evaluation (MMSE) Rey...
Abstract In central nervous system (CNS), demyelination is a pathological process featured with loss of myelin sheaths around axons, which responsible for the diseases multiple sclerosis, neuromyelitis optica, and so on. Transforming growth factor‐beta1 (TGF‐β1) multifunctional cytokine participating in abundant physiological processes CNS. However, effects TGF‐β1 on CNS demyelinating disease its underlying mechanisms are controversial not well understood. Herein, we evaluated protective...
With the development of wearable exoskeletons, people's demand for exoskeletons is no longer limited to functionality alone. The aesthetics and symbolic meanings have also become a focus attention. This paper aims propose method designing form active upper-limb based on product semantics, in order enhance their design meet workshop scenarios satisfy physical mental needs users. Firstly, it analyzes symbols uncovers appearance function market semantics semantics. Then, process proposed....
BACKGROUND: Chronic cerebral hypoperfusion-induced white matter lesions are an important cause of vascular cognitive impairment in aging life. TGF-β1 (transforming growth factor β1) is widely recognized as a multifunctional cytokine participating numerous pathophysiological processes the central nervous system. In this study, we aimed to evaluate neuroprotective potentials ischemic lesions. METHODS: A mouse model bilateral common carotid artery stenosis was established imitate The agonist...
A novel triple-mode hexagonal bandpass fllter with capacitive loading stubs is introduced in this article. The technique, adding an open stub, applied to enlarge the equivalent self- capacitance of resonator, which declines its resonant frequencies. Three radial-line center top layer are used implement technique. One mode frequency varied radii three stubs, while other two modes nearly not afiected. This has a pair transmission zeros close passband, thus it behaves high selectivity. For...
Chronic cerebral hypoperfusion induced cerebrovascular white matter lesions (WMLs) are closely associated with cognitive impairment and other neurological deficits. The mechanism of demyelination in response to has not yet been fully clarified. Soluble epoxide hydrolase (sEH) is an endogenous key enzyme the metabolic conversion degradation P450 eicosanoids called epoxyeicosatrienoic acids. Inhibition sEH suggested represent a prototype "combination therapy" targeting multiple mechanisms...