A5019110048- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Neuroinflammation and Neurodegeneration Mechanisms
- Connexins and lens biology
- Neural dynamics and brain function
- Lipid Membrane Structure and Behavior
- Neuroscience and Neural Engineering
- Cardiac electrophysiology and arrhythmias
- Gout, Hyperuricemia, Uric Acid
- Neurogenesis and neuroplasticity mechanisms
- Complex Systems and Time Series Analysis
- Traumatic Brain Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Climate Change and Health Impacts
- Stock Market Forecasting Methods
- Mitochondrial Function and Pathology
- Air Quality and Health Impacts
- Molecular Sensors and Ion Detection
- Health Promotion and Cardiovascular Prevention
- Brain Tumor Detection and Classification
- Epilepsy research and treatment
- Market Dynamics and Volatility
- Functional Brain Connectivity Studies
- Tryptophan and brain disorders
- Immune cells in cancer
University of California, San Diego
2025
The Ohio State University Wexner Medical Center
2015-2023
The Ohio State University
2019-2020
Nanjing Medical University
2011-2016
Jiangsu Province Hospital
2013-2016
Jiangsu Shengze Hospital
2014
Astrocytes are extensively coupled through gap junctions into a syncytium. However, the basic role of this major brain network remains largely unknown. Using electrophysiological and computational modeling methods, we demonstrate that membrane potential ( V M ) an individual astrocyte in hippocampal syncytium, but not single, freshly isolated cell preparation, can be well‐maintained at quasi‐physiological levels when recorded with reduced or K + free pipette solutions alter equilibrium to...
Abstract Microglial control of activity‐dependent plasticity and synaptic remodeling in neuronal networks has been the subject intense research past several years. Although microglia–neuron interactions have extensively studied, less is known about how microglia influence astrocyte‐dependent over structure function. Here, we explored a role for regulating function astrocyte syncytium mouse hippocampus. After depleting using CSF1R antagonist (PLX5622, Plexxikon), observed severe disruption...
Most patients with stroke caused by middle cerebral artery occlusion (MCAO) show cognitive deficit that is generally regarded as resulting from damage to the cortex rather than hippocampus. Whether MCAO induces hippocampal and whether this contributes defects remains unclear. Here we investigate its correlation after exclusively unilateral underlying mechanism for damage.Patients were assessed magnetic resonance imaging (MRI) angiography (MRA), Mini Mental-Status Evaluation (MMSE) Rey...
We have recently shown that a linear current-to-voltage (I-V) relationship of membrane conductance (passive conductance) reflects the intrinsic property K(+) channels in mature astrocytes. While passive is known to underpin highly negative and stable potential (V M) essential for basic homeostatic function astrocytes, complete repertoire involved remains elusive. TREK-1 two-pore domain channel (K2P) expressed covalent association with TWIK-1, another astrocytic K2P, has been reported as...
Abstract Syncytial isopotentiality, resulting from a strong electrical coupling, emerges as physiological mechanism that coordinates individual astrocytes to function highly efficient system in brain homeostasis. However, whether syncytial isopotentiality occurs selectively certain regions or is universal astrocytic networks remains unknown. Here, we have explored the correlation of with different astrocyte subtypes various regions. Using nonphysiological K + ‐free/Na electrode solution...
Neuronal hyperexcitability precedes synapse loss in certain neurodegenerative diseases, yet the synaptic membrane interactions and downstream signaling events remain unclear. The disordered amino terminus of prion protein (PrPC) has been implicated aberrant Alzheimer's disease. To disrupt neuronal linked to terminus, here we CRISPR-engineered a knock-in mouse expressing mutant PrPC (G92N), generating an N-linked glycosylation site between two functional motifs. Mice developed seizures...
Neonatal astrocytes are diverse in origin, and undergo dramatic change gene expression, morphological differentiation syncytial networking throughout development. also play multifaceted roles neuronal circuitry establishment. However, the extent to which neonatal differ from their counterparts adult brain remains unknown. Based on ALDH1L1-eGFP expression or sulforhodamine 101 staining, at postnatal day 1–3 can be reliably identified hippocampal stratum radiatum. They exhibit a more negative...
Abstract Astrocytes are increasingly shown to operate as an isopotential syncytium in brain function. Protoplasmic astrocytes acquire this ability functionally go beyond the single‐cell level by evolving into a spongiform morphology, cytoplasmically connecting syncytium, and expressing high density of K + conductance. However, none these cellular/functional features exist neonatal newborn astrocytes, which imposes basic question when functional evolves developing brain. Our results show that...
Mature astrocytes exhibit a linear current-to-voltage K(+) membrane conductance (passive conductance) and an extremely low resistance (Rm) in situ. The combination of these electrophysiological characteristics establishes highly negative stable potential that is essential for basic functions, such as spatial buffering neurotransmitter uptake. However, are coupled extensively It remains to be determined whether the observed passive behavior Rm attributable intrinsic properties ion channels or...
Due to strong electrical coupling, syncytial isopotentiality emerges as a physiological mechanism that coordinates astrocytes into highly efficient system in brain homeostasis. Although this electrophysiological phenomenon has now been observed astrocyte networks established by different subtypes, the spinal cord remains region is still unexplored. In ALDH1L1-eGFP transgenic mice, can be visualized confocal microscopy and grey matter are organized distinctive pattern. Namely, each resides...
Summary Astrocytes branch out and make contact at their interfaces. However, the ultrastructural interactions of astrocytes with surroundings, including spatial-location selectivity astrocyte-synapse contacts, remain unknown. Here, branching architecture three neighboring astrocytes, interfaces, surrounding neurites synapses have been traced 3D reconstructed using serial block-face scanning electron microscopy (SBF-SEM). Our reconstructions reveal extensive reflexive, loop-like processes...
Astrocyte syncytial isopotentiality is a physiological mechanism resulting from strong electrical coupling among astrocytes. We have previously shown that exists as system-wide feature coordinates astrocytes into system for high efficient regulation of brain homeostasis. Neuronal activity known to regulate gap junction through alteration extracellular ions and neurotransmitters. However, the extent which epileptic neuronal impairs unknown. Here, epileptiform bursts were induced in acute...
To examine the association between hemoglobin (Hb) levels and cardiovascular risk factors in a large community-dwelling cohort.A total of 4,186 women 4,851 men were enrolled study. Data on personal history, physical examination biochemical parameters collected. Subjects categorized by gender divided into different group according to level Hb or blood pressure, was examined using Pearson's correlation analysis.In both even with normal level, tertiles positively associated body mass index...
At present, the commonly used index selection methods for macroeconomic early‐warning research include K‐L information volume, time difference correlation analysis, and horse farm methods. These traditional statistical cannot cope with continuous changes of economic indicators, due to existence errors, these are difficult perform. Therefore, this paper proposes use a self‐organizing competitive neural network select early warning indicators. Its self‐learning adaptive characteristics fault...