A5033622365- Connexins and lens biology
- Medicinal Plant Pharmacodynamics Research
- Bone Metabolism and Diseases
- Heat shock proteins research
- Bioactive Natural Diterpenoids Research
- Metabolism, Diabetes, and Cancer
- Cancer-related molecular mechanisms research
- Retinal Development and Disorders
- Bioactive natural compounds
- Natural product bioactivities and synthesis
- Retinal Diseases and Treatments
- Simulation and Modeling Applications
- Hepatitis B Virus Studies
- Molecular Biology Techniques and Applications
- Power Systems and Technologies
- Biochemical Analysis and Sensing Techniques
- Microbial Community Ecology and Physiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Mitochondrial Function and Pathology
- CRISPR and Genetic Engineering
- Retinopathy of Prematurity Studies
- Natural Antidiabetic Agents Studies
- Mycotoxins in Agriculture and Food
- Smart Grid and Power Systems
- Advanced Algorithms and Applications
Zhaoqing University
2022-2025
Sun Yat-sen University
2014-2023
Duke-NUS Medical School
2017-2023
Wuhan City Chinese Medicine Hospital
2023
Sichuan Agricultural University
2020-2021
BGI Group (China)
2021
South Central Minzu University
2015-2020
Hubei University of Chinese Medicine
2020
Wuhan No.1 Hospital
2020
Jinan University
2019
Aflatoxin B1 (AFB1) is a mutagen and IARC (International Agency for Research on Cancer) Group 1 carcinogen that causes hepatocellular carcinoma (HCC). Here, we present the first whole-genome data mutational signatures of AFB1 exposure from total >40,000 mutations in four experimental systems: two different human cell lines, liver tumors wild-type mice, mice carried hepatitis B surface antigen transgene-this to model multiplicative effects aflatoxin causing HCC. all systems were remarkably...
The present study investigated the anti-diabetic activity and potential mechanism of stigmasterol (SMR), which is a kind phytosterols derived from edible soybean oil in vitro vivo. SMR displayed mild GLUT4 translocation by 1.44-fold L6 cells. cells were treated with different concentration SMR, showing significant effects on enhancing glucose uptake. administrated orally to KK-Ay mice significantly alleviated their insulin resistance oral tolerance reducing fasting blood-glucose levels blood...
Abstract Cataract refers to opacities of the lens that impede passage light. Mutations in heat shock transcription factor 4 ( HSF4 ) have been associated with cataract; however, mechanisms regarding how mutations cause cataract are still obscure. In this study, we generated an hsf4 knockout zebrafish model using TALEN technology. The mutant developed early-onset multiple developmental defects lens. epithelial cells were overproliferated, resulting overabundance fiber null Consequently,...
Retinitis pigmentosa (RP) affects about 1.8 million individuals worldwide. X-linked retinitis (XLRP) is one of the most severe forms RP. Nearly 85% XLRP cases are caused by mutations in 2 (RP2) and RPGR. RP2 has been considered to be a GTPase activator protein for ARL3 play role traffic ciliary proteins. The mechanism how cause RP still unclear. In this study, we generated an knockout zebrafish line using transcription activator-like effector nuclease technology. Progressive retinal...
This study investigated the active principles, hypoglycemic activity and potential mechanisms of flavonoid rich extract from Sophora tonkinensis Gagnep. (ST-EtOAc) in KK-Ay diabetic mice. An off-line semipreparative liquid chromatography-nuclear magnetic resonance (LC-NMR) chromatography-ultraviolet-electrospray ionization mass spectrometry (LC-UV-ESIMS) protocol was performed to determine 13 flavonoids ST-EtOAc. ST-EtOAc administrated orally mice significantly increased their sensibility...
Kurarinone, a flavonoid isolated from Sophora flavescens Aiton, has been reported to have significant antitumor activity. However, the cytotoxic activity of kurarinone against non-small cell lung cancer (NSCLC) cells is still under explored. In our study, we evaluated inhibitory effects on growth NSCLC both in vivo and vitro as well molecular mechanisms underlying kurarinone-induced A549 apoptosis. The results showed that effectively inhibited proliferation with little toxic human bronchial...
Purpose Ferroptosis is defined by the iron-dependent cell death caused accumulation of lipid peroxidation. As a major intracellular Fe pools, heme could be metabolized into ferrous iron, carbon monoxide, and biliverdin Heme oxygenase-1 (HMOX1). Aged human lens epithelium was reported to highly susceptible ferroptosis, functional molecular involved in this progress not explored. Here, we have demonstrated function HMOX1 during ferroptotic death.Methods stably expressed line constructed...
This study was designed to explore the effects and mechanism of isoliensinine (isolie) from embryos Nelumbo nucifera on type 2 diabetes dyslipidemia in vivo vitro. The vitro showed that isolie increased GLUT4 translocation by 2.5-fold L6 cells. Furthermore, after 4 weeks treatment, biochemical indexes revealed had a positive effect decreasing serum insulin level (42.2 ± 5.10 vs 55.7 6.33 mU/L, P < 0.05) reducing fast blood glucose (9.4 1.5 18.7 2.3 mmol/L, 0.001) body weight (37.8 2.9 46.9...
The rat partial optic nerve transection (PONT) model has been used for studying secondary degeneration of retinal ganglion cells (RGCs) in recent years. In this study, we carried out PONT the temporal side nerves, whereas was superior previous publication. We found that surgery is better and easier than method can produce a repeatable reliable model. detected significant changes polarization microglia/macrophages level autophagy nerves after PONT. also to detect effects polysaccharides...
Purpose . Glucocorticoid (GC) is the most important risk factor for osteoporosis (OP); in present study, we examined potential mechanism of icariin, a natural bioactive compound isolated from traditional Chinese herbal Epimedium , GC‐induced OP to explore its therapeutic effect. Methods We used mice model and treated with icariin. Pathological changes were measured by H&E staining, effects icariin on osteoblasts osteoclasts immunohistochemistry (IHC) staining western blot (WB) analyses,...
Due to strong electrical coupling, syncytial isopotentiality emerges as a physiological mechanism that coordinates astrocytes into highly efficient system in brain homeostasis. Although this electrophysiological phenomenon has now been observed astrocyte networks established by different subtypes, the spinal cord remains region is still unexplored. In ALDH1L1-eGFP transgenic mice, can be visualized confocal microscopy and grey matter are organized distinctive pattern. Namely, each resides...
Osteoarticular tuberculosis, a chronic inflammatory disease characterized by Mycobacterium tuberculosis (M.tb) infection, has become serious problem in China. The present study was conducted to determine the mechanism of action tumor necrosis factor (TNF)-α pathogenesis osteoarticular tuberculosis. number osteoclasts tissue samples detected tartrate-resistant acid phosphatase staining. Autophagy and apoptosis were western blotting, reverse transcription-quantitative PCR, transmission...