A5101399951- Migraine and Headache Studies
- Trigeminal Neuralgia and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Transcranial Magnetic Stimulation Studies
- Stroke Rehabilitation and Recovery
- Nicotinic Acetylcholine Receptors Study
- Neuroscience of respiration and sleep
- Alzheimer's disease research and treatments
- Neurological disorders and treatments
- Ion channel regulation and function
- Pain Mechanisms and Treatments
- Sympathectomy and Hyperhidrosis Treatments
- Adenosine and Purinergic Signaling
- Nuclear Structure and Function
- Restless Legs Syndrome Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiovascular Syncope and Autonomic Disorders
- Neurogenetic and Muscular Disorders Research
- Epilepsy research and treatment
- Pancreatic function and diabetes
- Neuroscience and Neuropharmacology Research
- Nuclear Receptors and Signaling
- Digital Imaging for Blood Diseases
- Glycogen Storage Diseases and Myoclonus
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
Jiangsu Province Hospital
2013-2024
Ningbo No.6 Hospital
2024
Nanjing Medical University
2012-2023
Sichuan University
2023
West China Hospital of Sichuan University
2023
First Affiliated Hospital of Guangzhou Medical University
2023
Guangzhou Medical University
2023
Wuhan Children's Hospital
2015
Second Affiliated Hospital of Nanjing Medical University
2009
Nanjing Brain Hospital
2009
Abstract Tumor-associated neutrophils (TANs) are important inflammatory infiltrating cells in the tumor microenvironment and closely related to development of human tumor. However, underlying mechanism TANs recruiting glioma remains unknown. Herein, we identified that LINC01116 was significantly upregulated glioma, positively correlated with clinical malignancy survival prognosis. regulated progression vitro vivo. RNA-seq analysis demonstrated knockdown affected expression IL-1β, which...
We have recently shown that a linear current-to-voltage (I-V) relationship of membrane conductance (passive conductance) reflects the intrinsic property K(+) channels in mature astrocytes. While passive is known to underpin highly negative and stable potential (V M) essential for basic homeostatic function astrocytes, complete repertoire involved remains elusive. TREK-1 two-pore domain channel (K2P) expressed covalent association with TWIK-1, another astrocytic K2P, has been reported as...
A characteristic phenotype of congenital generalized lipodystrophy 2 (CGL2) that is caused by loss-of-function seipin gene mental retardation. Seipin highly expressed in hippocampal pyramidal cells and astrocytes. Neuronal knockout mice (seipin-KO mice) reduces the peroxisome proliferator-activated receptor gamma (PPARγ) level without loss cells. The down-regulation PPARγ has gained increasing attention neuroinflammation Alzheimer's disease (AD). Thus, present study focused on exploring...
The production of inflammatory cytokines resulting from amyloid β (Aβ) is associated with the initiation Alzheimer's disease (AD). Atorvastatin (ATV) has been reported to improve AD, however, it unclear how anti-inflammatory mechanism linked its protection against impairment spatial cognitive function in AD. present study was designed explore what possibly involved pathway regard ATV treatment We used an AD model induced by administration Aβ25–35 male C57BL/6 mice and vitro culture system...
Loss-of-function mutation of Akt3 in humans has been associated with microcephaly and cognitive defects. Two Akt isoforms, Akt1 Akt3, are highly expressed hippocampal pyramidal cells. We explored the roles respectively, spatial cognition underlying mechanisms.We used knockout (Akt1-KO) (Akt3-KO) mice to examine influence deficiency on memory, as well induction maintenance CA1 NMDA receptor-dependent protein synthesis-dependent long-term potentiation (LTP).Long-term memory was impaired...
Abstact Background DRAGON was a phase 3, randomised, double-blind, placebo-controlled study which evaluated the efficacy and safety of erenumab in patients with chronic migraine (CM) from Asia not adequately represented global pivotal CM study. Methods conducted across 9 Asian countries or regions including mainland China, India, Republic Korea, Malaysia, Philippines, Singapore, Taiwan, Thailand, Vietnam. Patients ( N = 557) (aged 18–65 years) were randomised (1:1) to receive once-monthly...
Headache disorders are widely prevalent and pose a considerable economic burden on individuals society. Globally, misdiagnosis inadequate treatment of primary headache remain significant challenges, impeding the effective management such conditions. Despite advancements in over last decade, need for comprehensive evaluations status China regarding diagnosis preventative treatments persists.In present study, we analyzed established queries Survey Fibromyalgia Comorbidity with (SEARCH),...
Abstract Alzheimer’s disease (AD) is a common dementia and heterogeneous disease. Previous research has validated that microRNAs (miRNAs) are pivotal regulators in the initiation development of tremendous diseases including AD. MicroRNA-485-5p (miR-485-5p) was reported to be an important participant implicated several neurological diseases, but its role AD still needs further investigated. In this research, we explored biological function miR-485-5p RT-qPCR revealed expression downregulated...
Background and purpose: It has been generally thought that activation sensitization of the trigeminovascular system may contribute to pathogenesis migraine. Nevertheless, there is little evidence on abnormalities in peripheral trigeminal afferent nerves from humans vivo. Alterations corneal ophthalmic branch nerve support notion are involved migraine pathophysiology. The aim present study was investigate structural changes subbasal plexus patients with episodic (EM) vivo confocal microscope...
Background: Simvastatin (SV) has been reported to improve dementia and slow progression of Alzheimer’s disease (AD), however there are conflicting reports. Objective & Methods: Intracerebroventricular injection aggregated Aβ1-42 in mice (Aβ1-42-mice) caused spatial cognitive deficits, long-term potentiation (LTP) impairment, death hippocampal pyramidal cells. The present study focused on exploring the dose-dependent effects SV (10–80 mg/kg) Aβ1-42-impaired memory underlying mechanisms....
Increased insulin production and secretion by pancreatic β-cells are important for ensuring the high demand during gestation. However, underlying mechanism of β-cell adaptation gestation or gestational diabetes mellitus (GDM) remains unclear. Oxytocin is an physiological hormone in delivery, it also contributes to maintenance function. The aim this study was investigate role oxytocin pregnancy.The relationship between blood level function patients with GDM healthy pregnant women...