A5100686129- Pulmonary Hypertension Research and Treatments
- Bone Metabolism and Diseases
- Gastric Cancer Management and Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiovascular Function and Risk Factors
- Lung Cancer Treatments and Mutations
- Bone health and treatments
- Cardiovascular Issues in Pregnancy
- Bone health and osteoporosis research
- Cardiac Ischemia and Reperfusion
- Cancer, Lipids, and Metabolism
- Systemic Sclerosis and Related Diseases
- RNA modifications and cancer
- Hip and Femur Fractures
- Eosinophilic Disorders and Syndromes
- MicroRNA in disease regulation
- Gastrointestinal Tumor Research and Treatment
- NF-κB Signaling Pathways
- Mitochondrial Function and Pathology
- Sarcoma Diagnosis and Treatment
- Congenital Heart Disease Studies
- TGF-β signaling in diseases
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Renal cell carcinoma treatment
Jiangsu Province Hospital
2011-2025
Nanjing Medical University
2016-2025
Soochow University
2025
First Affiliated Hospital of Soochow University
2025
Chengdu Sport University
2024
Nanjing University of Chinese Medicine
2020-2024
Beijing Anzhen Hospital
2022-2024
Southern Medical University
2011-2024
Nanfang Hospital
2023-2024
Guangzhou Medical University
2020-2024
Lung adenocarcinoma (LUAD) remains a global health concern with its poor prognosis and high mortality. Whether tumor cells invade through the basement membrane (BM) is key factor to determine of LUAD. This study aimed identify BM-related gene signatures improve overall LUAD.A series bioinformatics analyses were conducted based on TCGA GEO datasets. Unsupervised consistent cluster analysis was performed, 500 LUAD patients assigned two different groups according expressions 222 genes. The...
ABSTRACT Background Right ventricular (RV) failure is a well‐recognized pivotal prognostic factor of adverse outcomes in pulmonary artery hypertension (PAH), while RV dilation provides significant implications for adaptive or maladaptive changes. PAH predominant cause mortality among patients with connective tissue disease (CTD). This study aims to elucidate the significance morphology, as assessed by echocardiography (ECHO), CTD associated (CTD‐PAH). Methods In this ambispective cohort...
Background: Epidural analgesia is a widely employed method in obstetric care for labor pain management. Postpartum urinary retention common complication that can arise during the postnatal period. This study aimed to evaluate current status and influencing factors of postpartum parturients who received epidural anesthesia. Methods: We retrospectively included underwent vaginal delivery at our institution from June 2022 October 2024. The characteristics with without were analyzed compared....
Pilocarpine is a prototypical drug used to treat glaucoma and dry mouth classified as either full or partial muscarinic agonist. Here, we report several unexpected results pertaining its interaction with M3 receptor (M3R). We found that pilocarpine was 1000 times less potent in stimulating mouse-eye pupil constriction than agonists oxotremorin-M (Oxo-M) carbachol (CCh), although all three ligands have similar Kd values for M3R. In contrast CCh Oxo-M, does not induce Ca2+ mobilization via...
Objective To compare and analyze the clinical outcomes of proximal humeral internal locking system (PHILOS) alone PHILOS combined with fibular allograft in treatment Neer three‐ four‐part humerus fractures (PHF) elderly. Methods From January 2014 to 2018, a total 42 elderly patients or PHF admitted our hospital were randomly divided into observation group control group, 21 each group. The was treated allograft. alone. Perioperative parameters fracture classification recorded two groups....
Osteoporosis is a metabolic bone disease commonly observed in the elderly, and its pathogenesis associated with declined osteogenic differentiation. Osteogenic differentiation could be facilitated by activation of AMP-activated protein kinase (AMPK) pathway. Saxagliptin, an anti-diabetic agent inhibitory effects against dipeptidyl peptidase 4 (DPP-4), has been recently reported to induce AMPK The present study proposes explore function mechanism Saxagliptin induction medium (ODIM) was...
The N6-methyladenosine (m
Approximately 30% of patients diagnosed with stage Ia-b NSCLC die recurrent disease after surgery. This study aimed to identify immune-related biomarkers that might predict tumor recurrence in within 40 months curative resection.Gene expression data samples was retrieved from the TCGA database, GEO databases, and Second Xiangya hospital (XXEYY) database. 22 types tumors infiltrating immune cells immune-associated genes were investigated using CIBERSORT, immunohistochemical staining, GSEA...
Most of the deaths among patients with severe pulmonary arterial hypertension (PAH) are caused by progressive right ventricular (RV) pathological remodeling, dysfunction, and failure. Nicorandil can inhibit development PAH reducing artery pressure RV hypertrophy. However, whether nicorandil apoptosis in cardiomyocytes prevent remodeling has been unclear.RV was induced rats intraperitoneal injection monocrotaline (MCT). systolic (RVSP) measured at end each week after MCT injection. Blood...
Abstract Objective: This study was to determine the bone protective effects and underlying mechanisms of Osthole (OT) in ovariectomized (OVX) mice. We found that inhibitory OT on receptor activator nuclear factor kappa-B ligand (RANKL)-activated osteoclastogenesis are responsible for its OVX Methods: Eight-week-old mice were (10 mg/kg/d) intraperitoneally administrated 7 days after surgery sacrificed at end 3 months. Osteoclasts generated from primary marrow macrophages (BMMs) investigate...
Developing recommendations for prostate cancer prevention requires identification of modifiable risk factors. Maternal exposure to high-fat diet (HFD) initiates a broad array second-generation adult disorders in murine models and humans. Here, we investigate whether maternal HFD mice affects incidence hyperplasia offspring. Using three independent assays, demonstrate that is sufficient initiate hyperproliferation male HFD-exposed tissues do not increase size, but instead concomitantly...
Calciphylaxis is a rare disease characterized histologically by microvessel calcification and microthrombosis, with high mortality no proven therapy. Here, we reported severe uremic calciphylaxis patient progressive skin ischemia, large areas of painful malodorous ulcers, mummified legs. Because the worsening symptoms signs refractory to conventional therapies, treatment human amnion-derived mesenchymal stem cells (hAMSCs) was approved. Preclinical release inspections hAMSCs, efficacy,...