A5103235178- Retinal Development and Disorders
- Alzheimer's disease research and treatments
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Advanced NMR Techniques and Applications
- Epigenetics and DNA Methylation
- Natural Compounds in Disease Treatment
- RNA regulation and disease
- Pulmonary Hypertension Research and Treatments
- Cellular transport and secretion
- Ocular Diseases and Behçet’s Syndrome
- RNA Research and Splicing
- Cancer-related gene regulation
- Renal cell carcinoma treatment
- Lung Cancer Diagnosis and Treatment
- Salivary Gland Disorders and Functions
- Protein Structure and Dynamics
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Hepatitis B Virus Studies
- Immunotherapy and Immune Responses
- Glaucoma and retinal disorders
- Molecular spectroscopy and chirality
- Cytokine Signaling Pathways and Interactions
- Neuroscience and Neuropharmacology Research
Nanjing Medical University
2013-2025
Jiangsu Province Hospital
2010-2025
First Affiliated Hospital Zhejiang University
2023
Yangpu Hospital of Tongji University
2023
Creative Commons
2023
The Affiliated Yongchuan Hospital of Chongqing Medical University
2023
Chongqing Medical University
2023
University of California, Los Angeles
2013-2022
Doheny Eye Institute
2015-2018
Heidelberg University
2013
Abstract Deposition of amyloid β (Aβ) in the brain is a pathological hallmark Alzheimer's disease. There are two major isoforms Aβ: 42‐residue Aβ42 and 40‐residue Aβ40. The only difference between Aβ40 that has extra residues at C‐terminus. plaques brains consist mostly some contain Aβ42, even though concentration several‐fold more than Aβ42. Using electron paramagnetic resonance, we studied formation fibrils using mixture vitro . We show form mixed an interlaced manner, although not as...
Celastrol is a triterpenoid compound extracted from the Chinese herb Tripterygium wilfordii Hook F. Previous research has revealed its anti-oxidant, anti-inflammatory, anti-cancer and immunosuppressive properties. Here, we investigated whether celastrol inhibits oxidized low-density lipoprotein (oxLDL) induced oxidative stress in RAW 264.7 cells. In addition, effect of on atherosclerosis vivo was assessed apolipoprotein E knockout (apoE−/−) mouse fed high-fat/high-cholesterol diet (HFC). We...
Oligomerization of the 42-residue peptide Aβ42 plays a key role in pathogenesis Alzheimer disease. Despite great academic and medical interest, structures these oligomers have not been well characterized. Site-directed spin labeling combined with electron paramagnetic resonance spectroscopy is powerful approach for studying structurally ill-defined systems, but its application amyloid oligomer structure study has systematically explored. Here we report comprehensive structural on toxic...
Aβ42 oligomers play key roles in the pathogenesis of Alzheimer disease, but their structures remain elusive partly due to transient nature. Here, we show that a fusion construct can be trapped stable oligomer state, which recapitulates characteristics prefibrillar and enables us establish detailed structures. Site-directed spin labeling electron paramagnetic resonance studies provide structural restraints terms side chain mobility intermolecular distances at all 42 residue positions. Using...
ABSTRACT Background Right ventricular (RV) failure is a well‐recognized pivotal prognostic factor of adverse outcomes in pulmonary artery hypertension (PAH), while RV dilation provides significant implications for adaptive or maladaptive changes. PAH predominant cause mortality among patients with connective tissue disease (CTD). This study aims to elucidate the significance morphology, as assessed by echocardiography (ECHO), CTD associated (CTD‐PAH). Methods In this ambispective cohort...
<title>Abstract</title> Background Cancer is a global health issue, and as conventional treatments' side effects become more noticeable, many patients turn to complementary therapies, especially traditional Chinese medicine exercises. These exercises help regulate the mind body, enhance immune function, alleviate effects. Despite their potential, bibliometric studies on this topic are limited. Methods This study analyzed literature from Web of Science Core Collection (WoSCC) 2011 2024, using...
This study aims to compare the performance of AIMS65, Glasgow-Blatchford (GBS) and Rockall scores (RS) in predicting death risk among emergency-hospitalized patients with upper gastrointestinal bleeding (UGIB) regional China.A retrospective was implemented between January 2014 December 2015. Eligible participants were those who hospitalized UGIB. The outcome variable in-hospital death, while explanatory variables GBS RS scores. Odds ratios (OR) 95% confidence interval (CI) estimated assess...
Autologous hematopoietic stem cell (HSC) and mesenchymal (MSC) transplantation is currently being evaluated as a novel treatment for autoimmune diseases, such systemic lupus erythematosus (SLE). Here we report case of autologous HSC combined with MSCs in 25-year-old severe SLE patient multiple life-threatening complications refractory to conventional cyclophosphamide (CYC) therapy. After pretreated CYC, fludarabine antithymocyte globulin, the was transplanted CD34+HSCs by intravenous...
This study examines retinas from a rat glaucoma model for oxidized nucleosides 8OHdG and 8OHG, biomarkers oxidative damage of DNA RNA, respectively. Immunohistochemical data indicate predominant localization 8OHdG/8OHG in retinal ganglion cells (RGCs). The levels these DNA/RNA products were 3.2 2.8 fold higher at 1 2 weeks after intraocular pressure elevation compared to control retinas, almost exclusively associated with mitochondrial DNA/RNA: ~ 65% RNA isolated fraction 35% DNA....
Formation of amyloid fibrils is involved in a range fatal human disorders including Alzheimer, Parkinson, and prion diseases. Yeast prions, despite differences sequence from their mammalian counterparts, share similar features with prions infectivity, strain phenomenon, species barrier thus are good model systems for normally have long domains that presumably form multiple β strands the fibril, structural knowledge about yeast has been limited. Here we use site-directed spin labeling...
Although B cells have been shown to contribute the pathogenesis of rheumatoid arthritis (RA), precise role in RA needs be explored further. Our previous studies revealed that adiponectin (AD) is expressed at high levels inflamed synovial joint tissues, and its expression closely correlated with progressive bone erosion patients RA. In this study, we investigated possible AD cell proliferation differentiation. We found stimulation could induce differentiation culture. Notably, local...
The role played by cytokines, other than interferon (IFN)-α, in the differentiation and function of dendritic cells (DCs) systemic lupus erythematosus (SLE), remains unclear. Serum interleukin-10 (IL-10) levels are generally elevated SLE patients, which might modulate DCs. In this study, DCs were induced from monocytes either transendothelial trafficking or culture with granulocyte-macrophage colony-stimulating factor (GM-CSF) + IL-4 tumor necrosis (TNF)-α. Both systems used to investigate...
Glucocorticoid-induced tumor necrosis factor receptor family-related protein (GITR) is a type I transmembrane belonging to the TNFR superfamily. After activated by its ligand GITRL, GITR could influence activity of effector and regulatory T cells, participating in development several autoimmune inflammatory diseases included rheumatoid arthritis thyroid disease. We previously reported that serum GITRL levels are increased systemic lupus erythematosus (SLE) patients compared with healthy...
Abstract Introduction Primary Sjögren’s syndrome (pSS) is a chronic systemic autoimmune disease which has focal lymphocytic infiltration including majority of CD4+ T cells. This study was to investigate the correlation peripheral granzyme B (GranzB)-expressing cells with severity and histological lesion in patients pSS. Methods We recruited 116 pSS 46 health control (HC) using flow cytometry examine percentage CD4+GranzB+CTLs blood, immunofluorescence test their expression labial gland....
The influence of human genetics on the natural history hepatitis B virus (HBV) infection may be diminished in endemic areas because at a young age predisposes to chronic HBV infection. present study aimed address this issue through determination influences single nucleotide polymorphisms (SNPs) myxovirus resistence-1 (MxA) -88 G/T and interferon (IFN)-gamma +874 A/T regions. One hundred adult patients with self-limiting (positive for both anti-HBs anti-HBc) 340 persistent were recruited from...