A5100621442- Pulmonary Hypertension Research and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Renin-Angiotensin System Studies
- Sulfur Compounds in Biology
- Cardiovascular Disease and Adiposity
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Cardiovascular Function and Risk Factors
- Cancer-related molecular mechanisms research
- Chemotherapy-induced cardiotoxicity and mitigation
- Receptor Mechanisms and Signaling
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Dietary Effects on Health
- Genomics, phytochemicals, and oxidative stress
- Rheumatoid Arthritis Research and Therapies
- PI3K/AKT/mTOR signaling in cancer
- Cell Adhesion Molecules Research
- Cardiovascular Issues in Pregnancy
- Nitric Oxide and Endothelin Effects
- interferon and immune responses
- Autophagy in Disease and Therapy
- Berberine and alkaloids research
- Pelvic and Acetabular Injuries
- Biological and pharmacological studies of plants
- Hippo pathway signaling and YAP/TAZ
Nanjing Medical University
2016-2025
Shanghai Traditional Chinese Medicine Hospital
2025
Pudong Medical Center
2025
Wenzhou Medical University
2025
Ministry of Education of the People's Republic of China
2024-2025
Anhui Medical University
2024-2025
Henan Provincial People's Hospital
2024
Zhengzhou Central Hospital
2024
Second Affiliated Hospital of Nanjing Medical University
2024
Soochow University
2020-2023
Hydrogen sulfide (H2S) has been shown to have powerful antioxidative and anti-inflammatory properties that can regulate multiple cardiovascular functions. However, its precise role in diabetes-accelerated atherosclerosis remains unclear. We report here H2S reduced aortic atherosclerotic plaque formation with reduction superoxide (O2 (-)) generation the adhesion molecules streptozotocin (STZ)-induced LDLr(-/-) mice but not LDLr(-/-)Nrf2(-/-) mice. In vitro, inhibited foam cell formation,...
Oxidative stress is a key contributor to endothelial dysfunction and associated cardiovascular pathogenesis. Hydrogen sulfide (H2S) an antioxidant gasotransmitter that protects cells against oxidative stress. Sirtuin3 (SIRT3), which belongs the silent information regulator 2 (SIR2) family, important deacetylase under H2S able regulate activity of several sirtuins. The present study aims investigate role SIRT3 in effect cells.Cultured EA.hy926 were exposed hydrogen peroxide (H2O2) as model...
Background and Aims Protein S‐sulfhydration mediated by H 2 S has been shown to play important roles in several diseases. However, its precise role liver disease the related mechanism remain unclear. Approach Results We showed that streptozotocin (STZ)–treated high‐fat diet (HFD)–treated low‐density lipoprotein receptor–negative (LDLr −/− ) mice, donor GYY4137 ameliorated injury, decreased serum alanine aminotransferase (ALT) aspartate (AST) levels, mitigated lipid deposition, reduced...
Abstract The association between psoriasis and cardiovascular disease (CVD) has long been discussed continually refined. However, there is currently a lack of prospective studies on the risk attributed to in United States general population. Representative adult participants were selected from National Health Nutrition Examination Survey (NHANES). Risks symptoms diseases prevalence evaluated with without psoriasis. hazards for all‐cause mortality CVD stratified by status. Mediation analysis...
Abstract Atherosclerosis is initiated by vascular endothelial dysfunction, and low-shear stress (LSS) of blood flow a key factor leading to dysfunction. Growing evidence suggests that cell pyroptosis plays an important role in the development atherosclerosis. Studies have shown can induce pyroptosis, but exact mechanism remains unclear. Our experiments demonstrated induced phosphorylation IκB kinase ε (IKKε). IKKε knockdown not only significantly attenuated atherosclerosis lesions aortic...
Celastrol is a triterpenoid compound extracted from the Chinese herb Tripterygium wilfordii Hook F. Previous research has revealed its anti-oxidant, anti-inflammatory, anti-cancer and immunosuppressive properties. Here, we investigated whether celastrol inhibits oxidized low-density lipoprotein (oxLDL) induced oxidative stress in RAW 264.7 cells. In addition, effect of on atherosclerosis vivo was assessed apolipoprotein E knockout (apoE−/−) mouse fed high-fat/high-cholesterol diet (HFC). We...
The purpose of this study was to assess the clinical outcome percutaneous kyphoplasty (PKP) assisted with mixed reality (MR) technology in treatment osteoporotic vertebral compression fracture (OVCF) intravertebral vacuum cleft (IVC).Forty cases OVCF IVC undergoing PKP were randomized into a MR technology-assisted group (group A) and traditional C-arm fluoroscopy B). Both groups performed evaluated by VAS scores, ODI radiological evidence body height, kyphotic angle (KA) at pre-operation...
Background Hydrogen sulfide (H 2 S) is a gasotransmitter that regulates multiple cardiovascular functions. Krüppel‐like factor 5 (KLF5) exerts diverse functions in the system. Whether and how H S KLF5 myocardial hypertrophy unknown. Methods Results In our study, hypertrophic samples clinic were collected underwent histological molecular biological analysis. Spontaneously hypertensive rats neonatal rat cardiomyocytes studied for functional signaling responses to GYY4137, an S‐releasing...
Atherosclerosis-related cardiovascular diseases are leading causes of mortality worldwide, characterized by the development endothelial cell dysfunction, increased oxidized low-density lipoprotein uptake macrophages, and ensuing formation atherosclerotic plaque. Local blood flow patterns cause uneven lesion distribution, dysfunction caused disturbed is an early step in atherosclerosis. The present research aims to elucidate mechanism underlying regulation Neuropilin 2 (NRP2) under low shear...
Abstract Rationale Coronary artery plaques often develop in regions subjected to disturbed shear stress (DSS), yet the mechanisms underlying this phenomenon remain poorly understood. Our study aimed elucidate unknown role of MAPK6 and plaque formation. Methods In vitro vivo experiments, RNA‐seq, CO‐IP proteomic analysis, combined with single‐cell RNA‐seq datasets were used reveal upstream downstream involved. AAV‐MAPK6, ApoE −/− flox/flox TEK Cre mice CXCL12 neutraligand confirm beneficial...
Background: Vascular calcification (VC) is a common pathologic state that often accompanies calcium-phosphorus metabolism disorder and chronic kidney diseases (CKDs) in aging individuals. smooth muscle cell (VSMC) has been widely acknowledged as one of the main types involved this process. Niacin, lipid-lowering reagent, demonstrated to be beneficial atherosclerotic disease. The correlation mechanism between niacin vascular have not reported so far. Methods results: RCS analysis based on...
Previous studies have suggested that exogenous hydrogen sulfide can alleviate the development of diabetic cardiomyopathy (DCM) by inhibiting oxidative stress, inflammation, and apoptosis. However, underlying mechanism is not fully understood. Nuclear expression function transcription factor Forkhead box protein O (FoxO1) been associated with cardiovascular diseases, thus, importance FoxO1 in DCM has gained increasing attention. This study was designed to investigate interactions between (H2...
Krüppel-like factor 4 (KLF4) is a transcription with conserved zinc finger domains. As an essential regulator of vascular homeostasis, KLF4 exerts protective effect in endothelial cells (ECs), including regulating vasodilation, inflammation, coagulation and oxidative stress. However, the underlying mechanisms modifying activity mediating function remain poorly understood. Recently, roles for S-nitrosation have been implicated many pathophysiologic processes cardiovascular disease. Here, we...
Oscillatory shear stress (OSS) disrupts endothelial homeostasis and promotes oxidative stress, which can lead to atherosclerosis. In atherosclerotic lesions, Toll-like receptor 4 (TLR4) is highly expressed. However, the molecular mechanism by TLR4 modulates changes cell signaling transudation upon OSS yet be determined.Carotid artery constriction (CAC) surgery a parallel-plate flow chamber were used modulate stress. The results showed that significantly increased burden, this was partly due...
Hypoxia-induced excessive pulmonary artery smooth muscle cell (PASMC) proliferation plays an important role in the pathology of arterial hypertension (PAH). Berberine (BBR) is reported as effective antiproliferative properties applied clinical. However, effect BBR on PAH remains unclear. In present study, we elucidated protective effects against abnormal PASMC and vascular remodeling chronic hypoxia-induced hearts. Furthermore, potential mechanisms were investigated. For this purpose,...