A5008940550- RNA modifications and cancer
- Insect symbiosis and bacterial influences
- Machine Learning in Bioinformatics
- Rheumatoid Arthritis Research and Therapies
- Cancer-related molecular mechanisms research
- Insect and Pesticide Research
- Insect Resistance and Genetics
- Studies on Chitinases and Chitosanases
- Molecular Biology Techniques and Applications
- Microbial Community Ecology and Physiology
- Insect Utilization and Effects
- Advanced Optical Imaging Technologies
- Hydrocarbon exploration and reservoir analysis
- Polyamine Metabolism and Applications
- CRISPR and Genetic Engineering
- Genomics and Phylogenetic Studies
- Image Enhancement Techniques
- Global Energy and Sustainability Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Methane Hydrates and Related Phenomena
- Grey System Theory Applications
- Pineapple and bromelain studies
- Gut microbiota and health
- Adipokines, Inflammation, and Metabolic Diseases
- Microbial infections and disease research
Hainan University
2023-2024
Cell Technology (China)
2021-2023
Southern Medical University
2021-2023
Tangshan Normal University
2023
Hebei Agricultural University
2021-2023
Guangxi Normal University for Nationalities
2022
Kuaishou (China)
2021
OriginWater (China)
2021
Institute of Biophysics
2015-2019
Chinese Academy of Sciences
2015-2019
Aging is tightly associated with redox events. The free radical theory of aging indicates that imbalance may be an important factor in the process. Most studies about and focused on static status oxidative stress levels, there has been little research investigating differential responses to challenge during aging. In this study, we used Caenorhabditis elegans human fibroblasts as models compare young old individuals. response paraquat stress, individuals generated more ROS activated...
The majority of diabetic patients develop neuropathy and there is an increasing prevalence neurodegeneration in the central nervous system (CNS). However, mechanism behind this poorly understood. Here we first observed that macroautophagy/autophagy was suppressed hippocampus GK rats with hyperglycemia, whereas it unchanged ob/ob mice without hyperglycemia. Autophagy could be directly inhibited by high glucose mouse primary hippocampal neurons. Moreover, autophagy protective...
A promoter is a specific sequence in DNA that has transcriptional regulatory functions, playing role initiating gene expression. Identifying promoters and their strengths can provide valuable information related to human diseases. In recent years, computational methods have gained prominence as an effective means for identifying promoter, offering more efficient alternative labor-intensive biological approaches.
Krüppel-like factor 4 (KLF4) is a transcription with conserved zinc finger domains. As an essential regulator of vascular homeostasis, KLF4 exerts protective effect in endothelial cells (ECs), including regulating vasodilation, inflammation, coagulation and oxidative stress. However, the underlying mechanisms modifying activity mediating function remain poorly understood. Recently, roles for S-nitrosation have been implicated many pathophysiologic processes cardiovascular disease. Here, we...
The Beet armyworm Spodoptera exigua (Lepidoptera: Noctuidae, Spodoptera) is an important global polyphagous pest. Pathogen infection could destroy the intestinal microbial homeostasis of insects, leading to death host. However, effect host community on insecticidal Bacillus thuringiensis rarely studied. In this study, genome characteristics Bt GS57 and diversity functions gut bacteria in S. are investigated using crystal morphology, biological activity, Illumina HiSeq high-throughput...
Methane seeps are chemosynthetic ecosystems in the deep-sea environment. Microbial community structures have been extensively studied seepage-affected sediments and investigation water column above seeping sites is still lacking. In this study, prokaryotic communities bottom about 50 cm from seabed at methane with various seepage intensities Haima, South China Sea were comparatively by using 16S ribosomal RNA gene sequencing. These assigned based on their distinct content levels seafloor...
As a systemic inflammatory arthritis disease, rheumatoid (RA) is complex and hereditary. Traditional Chinese medicine (TCM) has evident advantages in treating diseases, variety of TCM formulas have been reported that effective treatment on RA. Clinical pharmacological studies showed Ermiao Powder, which consists Phellodendron amurense Rupr. (PAR) Atractylodes lancea (Thunb.) DC. (ALD), can be used the Currently, most focus anti-inflammatory mechanism PAR ALD are less focused their...
In the dairy industry, glutamine (Gln) is often used as a feed additive to increase milk yield and quality; however, molecular regulation underneath needs further clarification. Here, with bovine mammary epithelial cells (BMECs), effects mechanisms of Gln on cell growth casein synthesis were assessed. When was added or depleted from BMECs, both β-casein (CSN2) expression increased decreased, respectively. Overexpressing inhibiting mechanistic target rapamycin (mTOR) revealed that regulated...
The gut microbiota is essential for the growth and development of insects, intestinal immune system plays a critical role in regulating homeostasis microorganisms their interactions with pathogenic bacteria. Infection Bacillus thuringiensis (Bt) can disrupt but regulatory factors governing interaction between Bt bacteria are not well understood. Uracil secreted by exogenous activate DUOX-mediated reactive oxygen species (ROS) production, which helps maintain microbial balance. To elucidate...
RNA-seq has been widely used to reveal the molecular mechanism of variants life process. We have developed an alternative method, MustSeq, which generates multiple second strands along a single 1st strand cDNA by random-priming initiation, immediately after reverse transcription for each RNA extract using sample-barcoded poly-dT primers, then 3' ends-enriching PCR is applied construct library. Unlike conventional seq, MustSeq avoids procedures such as mRNA isolation, fragmentation and 5'-end...
With the rapid development of machine learning and artificial intelligence, research prediction models is becoming more popular. This paper aims to propose a general model analyze importance features. First, this builds GBDT(Gradient boosting decision tree) finally, LightGBM (Light Gradient Boosting Machine) algorithm based on Bagging Ensemble algorithm. MAPE R2 were set as test indicators, 31 groups data from 1992 2022 selected for training learning. The results show that: (1) GBDT-LightGBM...
Abstract Chitin deacetylases (CDAs) convert chitin into chitosan and play crucial roles in the insect biological processes, including growth development. In this study, two CDA‐encoding genes, HcCDA1 HcCDA4 , were identified from Hyphantria cunea . Conserved Domain Database for a chitin‐binding peritrophin‐A domain (ChBD), low‐density lipoprotein receptor class A (LDLa), putative CDA‐like catalytic (CDA), whereas lacked LDLa domain. Phylogenetic comparison with other CDAs revealed that...
Background: To improve the prevention and control of diseases level feeding management newborn calves, diversity analysis their gut microbiota was conducted to explore changes in during different seasons. Methods: Based on metagenomic sequencing high-throughput techniques, microbiota, functional abundance, differences resistance genes diarrhea calves seasons were analyzed. Result: At phylum level, Firmicutes Actinobacteria have always been significant dominant four seasons; at genus...
Understanding wildlife activity and the temporal niches of animals is fundamental in revealing mechanism niche differentiation among sympatric species coexistence such communities.However, there no clarity on whether patterns red-bellied squirrels (Callosciurus erythraeus) Northern tree shrews (Tupaia belangeri) overlap; knowledge these karst habitat also minimal.Herein, we used camera traps to collect photos research by using kernel density estimation coefficient overlap explore animals'...