A5100624299- Amino Acid Enzymes and Metabolism
- Biochemical and Molecular Research
- ATP Synthase and ATPases Research
- Cancer, Hypoxia, and Metabolism
- PI3K/AKT/mTOR signaling in cancer
- Epigenetics and DNA Methylation
- Biochemical Acid Research Studies
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Protein Tyrosine Phosphatases
- S100 Proteins and Annexins
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Histone Deacetylase Inhibitors Research
- Cancer Cells and Metastasis
- Estrogen and related hormone effects
- Cancer Genomics and Diagnostics
- Viral Infectious Diseases and Gene Expression in Insects
- HER2/EGFR in Cancer Research
- Genetic factors in colorectal cancer
- Studies on Chitinases and Chitosanases
- Thyroid Cancer Diagnosis and Treatment
- Enzyme Structure and Function
- Chronic Lymphocytic Leukemia Research
- Chemical Reactions and Isotopes
Anyang Institute of Technology
2024
Wuhan Municipal Engineering Design & Research Institute
2024
Shanxi Agricultural University
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2023
Harbin University of Commerce
2023
Genesis Foundation
2023
Chongqing University
2023
East China Normal University
2023
Weatherford College
2022
Shaanxi University of Chinese Medicine
2022
Food-derived antioxidant peptides can be explored as natural antioxidants due to their potential health benefits. In this study, were isolated and purified from pea protein hydrolysates (PPH). The DPPH ABTS radical scavenging activities used indexes purify the by a series of purification steps including ultrafiltration, ion exchange chromatography, G25 gel filtration reversed-phase chromatography. Three novel YLVN, EEHLCFR TFY identified, which all exhibited strong activity in vitro. showed...
Distraction osteogenesis (DO) is a widely used bone regenerative technique. However, the DO process slow, and consolidation phase long. Therefore, it of great clinical significance to explore mechanism DO, shorten its duration. Recent studies reported that stem cell exosomes may play an important role in promoting angiogenesis related but remains unclear.Canine endothelial colony-forming cells (ECFCs) were isolated cultured, expression THBS1 canine ECFCs inhibited using lentiviral vector....
Adipose tissue plays a crucial role in energy metabolism. Several studies have shown that circular RNA (circRNA) is involved the regulation of fat development and lipid However, little known about their involvement adipogenic differentiation ovine stromal vascular fractions (SVFs). Here, based on previous sequencing data bioinformatics analysis, novel circINSR was identified sheep, which acts as sponge to promote miR-152 inhibiting SVFs. The interactions between were examined using...
Superoxide dismutase (SOD) is an enzyme found in most food sources, might be a candidate to reduce oxidative damage intestinal barrier, thereby ameliorating the vicious circle between hyperglycemia and damage. Here we report oral administration of SOD, liposome-embedded SOD (L-SOD), hydrolysate type 2 diabetic model rats confirm this hypothesis. Oxidative severity rat intestine was indicated by malondialdehyde level, GSSG/GSH ratio, antioxidant activity. The significantly repaired L-SOD....
Abstract Background We aimed to build a common terminology in the domain of cervical cancer, named Cervical Cancer Common Terminology (CCCT), that will facilitate clinical data exchange, ensure quality and support large scale analysis. Methods The standard concepts relations CCCT were collected from ICD-10-CM Chinese Version, ICD-9-PC officially issued commonly used terms, guidelines for diagnosis treatment cancer medical book Lin Qiaozhi Gynecologic Oncology. 2062 electronic records (EMRs)...
摘要:
Purpose: To study the possible anti-cancer effects of miR-744 on human gastric cancer cells, and underlying mechanism.
 Methods: The mRNA expression was determined using qRT-PCR, while CCK-8, Annexin V/PI acridine orange assays were used to determine cell viability, apoptosis autophagy, respectively. expressions target proteins qRT-PCR Immunoblotting.
 Results: Significant suppressions observed in tissues lines. Overexpression inhibited proliferation silencing promoted cells....
<p>informations for experiments</p>
<p>informations for experiments</p>
<div>Abstract<p>Studies of the estrogen receptor (ER) coactivator protein Mediator subunit 1 (MED1) have revealed its specific roles in pubertal mammary gland development and potential contributions to breast tumorigenesis, based on coamplification MED1 HER2 certain cancers. In this study, we generated a mouse model tumorigenesis harboring MMTV-HER2 oncogene mutation evaluate role HER2-driven tumorigenesis. ER-interacting LxxLL motifs was sufficient delay tumor onset impair...
<div>Abstract<p>While phosphatidylinositol 4-kinase (PI4KIIα) has been identified as a potential target for antitumor therapy, the clinical applications of PI4KIIα are limited by lack specific inhibitors. Here we report first small-molecule inhibitor (SMI) human PI4KIIα. Docking-based and ligand-based virtual screening strategies were employed to identify promising hits, followed two rounds kinase activity inhibition validation....
<p>A 200 ns molecular dynamic simulation of the open conformation PDK1, in which sidechain R286 swung towards different sides.</p>