A5101694576- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- Gout, Hyperuricemia, Uric Acid
- MicroRNA in disease regulation
- Adenosine and Purinergic Signaling
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Eicosanoids and Hypertension Pharmacology
- Urticaria and Related Conditions
- Cancer-related molecular mechanisms research
- Reproductive System and Pregnancy
- Circular RNAs in diseases
- Autophagy in Disease and Therapy
- RNA modifications and cancer
- Eosinophilic Disorders and Syndromes
- Atherosclerosis and Cardiovascular Diseases
- Ion Transport and Channel Regulation
- Breast Cancer Treatment Studies
- interferon and immune responses
- Inflammasome and immune disorders
- Extracellular vesicles in disease
- Liver Disease Diagnosis and Treatment
- RNA Research and Splicing
- HER2/EGFR in Cancer Research
- Diet, Metabolism, and Disease
Peking University
2016-2025
Tianjin Medical University Cancer Institute and Hospital
2020-2024
Minzu University of China
2024
University of Science and Technology of China
2018-2023
Ministry of Education of the People's Republic of China
2023
Anhui Provincial Hospital
2013-2021
Anhui Medical University
2013-2019
Harbin Medical University
2018-2019
Fourth Affiliated Hospital of Harbin Medical University
2018-2019
Myocardial ischemia-reperfusion (I/R) injury causes cardiac dysfunction to myocardial cell loss and fibrosis. Prevention of death is important protect function after I/R injury. The process reperfusion can lead multiple types cardiomyocyte death, including necrosis, apoptosis, autophagy, ferroptosis. However, the time point at which various modes occur mechanisms underlying ferroptosis regulation in cardiomyocytes are still unclear.Using a left anterior descending coronary artery ligation...
As a novel type of non-coding RNAs, covalently closed circular RNAs (circRNAs) are ubiquitously expressed in eukaryotes. Emerging studies have indicated that dysregulation circRNAs was related to neurological diseases. However, the biogenesis, regulation, function, and mechanism Parkinson's disease (PD) remain largely unclear. In this study, thirty-three differentially (DECs) were detected by RNA-sequencing between MPTP-induced PD mice model wild-type mice. Quantitative real-time PCR used...
Mounting evidence showed that HER2-Low breast cancer patients could benefit from the novel anti-HER2 antibody–drug conjugates (ADCs) treatment, which pointed way towards better therapy for patients. The purpose of this study was to describe clinicopathological features, along with chemotherapeutic effects and survival outcomes HER2-Zero in TNBC who received neoadjuvant chemotherapy (NACT). We retrospectively evaluated 638 triple-negative were treated between August 2014 2022. Pathologic...
Abstract Protein tyrosine phosphatase interacting protein 51 (PTPIP51) participates in multiple cellular processes, and dysfunction of PTPIP51 is implicated diseases such as cancer neurodegenerative disorders. However, there no functional evidence showing the physiological or pathological roles heart. We have therefore investigated role mechanisms regulating cardiac function. found that was markedly upregulated ischemia/reperfusion Upregulation by adenovirus-mediated overexpression increased...
Autophagy including mitophagy serves as an important regulatory mechanism in the heart to maintain cellular homeostasis and protect against damages caused by myocardial infarction (MI). The current study aims dissect roles of general autophagy specific regulating cardiac function after MI. By using Beclin1+/- , Fundc1 knockout (KO) transgenic (TG) mouse models, combined with starvation MI we found that KO more severe mitochondrial dysfunction than Interestingly, notable decrease total...
Abstract Myocardial infarction is caused by insufficient coronary blood supply, which leads to myocardial damage and eventually the heart failure. Molecular mechanisms associated with loss of cardiomyocytes during (MI) ischemia-related cardiac diseases are not yet fully understood. Nogo-C an endoplasmic reticulum protein ubiquitously expressed in tissues including heart, however, function still unknown. In present study, we found that was upregulated mouse hearts after MI, hypoxic treatments...
B cells are recognized as key participants in various autoimmune diseases, including systemic lupus erythematosus (SLE). Although sets of transcription factors and cytokines known to regulate cell differentiation, the roles microRNAs poorly understood. Our previous study proved that microRNA-326 (miR-326) was markedly upregulated SLE patients; however, biological function miR-326 during pathogenesis remained unknown. In this study, we found overexpression MRL/lpr mice led hyperactivity...
Abstract Background Increasing evidence has indicated the important role of long non-coding RNAs (lncRNAs) in regulating development and progression cancers, including triple-negative breast cancer (TNBC). Small nucleolar RNA host gene 22 (SNHG22) is a novel lncRNA that been identified as tumor-contributor ovarian carcinoma. However, its function not explored TNBC. Methods qRT-PCR was used to identify expression at mRNA level while western blot utilized analyze protein level. Functional...
To investigate the effect of P2X7R on MSU crystal-induced acute gouty arthritis in rats and its mechanism inflammatory responses.
Atherosclerosis results from a maladaptive inflammatory response initiated by the intramural retention of LDL in susceptible areas arterial vasculature. The ω-3 polyunsaturated fatty acids (ω-3) have protective effects atherosclerosis; however, their molecular mechanism is still largely unknown. present study used metabolomic approach to reveal atheroprotective metabolites and investigate underlying mechanisms.We evaluated development atherosclerosis receptor-deficient mice (LDLR-/- ) fed...
Background Chronic liver injury (CLI) is now a worldwide disease. However, there no effective treatment. Pyroptosis plays an essential role in CLI. Dihydromyricetin (DHM) resists oxidation and protects the liver. We hypothesize that beneficial effect of DHM on CLI related to its expression pyroptosis-related molecules. Therefore, we studied influence pyroptosis. Aim To study pyroptosis pathogenesis therapeutic mechanism DHM. Methods Thirty-two mice were randomly divided into four groups: The...
Triple-negative breast cancer (TNBC) patients who recur at different times are associated with distinct biological characteristics and prognoses. Research on rapid-relapse TNBC (RR-TNBC) is sparse. In this study, we aimed to describe the of recurrence, predictors for relapse, prognosis in rrTNBC patients.Clinicopathological data 1584 from 2014 2016 were retrospectively reviewed. The recurrence compared between RR-TNBC slow relapse TNBC(SR-TNBC). All randomly divided into a training set...
Background: Autophagy executes the rapid degradation of unneeded proteins and organelles through lysosomal pathway, is a crucial catabolic process widely conserved among eukaryotes. miRNAs can modulate autophagy by targeting genes encoding involved in process. A great deal researchhas indicated that miR-216a was functional miRNA related to tumorigenesis. However, contribution colorectal cancer (CRC) remains unclear. The purpose this study investigate role CRC cells. Methods: expression...
In recent years, chronic liver injury has become a common disease that harms human health. Its clinical manifestations are hepatic steatosis and secondary steatohepatitis, which can quickly transform into fibrosis cirrhosis if not treated in time. Therefore, this study is aimed at searching for new therapeutic targets of clarifying the molecular mechanisms involved injury. After aquaporin 9 was identified as target by proteomics, Aqp9 -/- mice were constructed using CRISPR/Cas9 system....