A5101662183- Heme Oxygenase-1 and Carbon Monoxide
- Acupuncture Treatment Research Studies
- Autophagy in Disease and Therapy
- Thermal Regulation in Medicine
- Cancer, Hypoxia, and Metabolism
- Eicosanoids and Hypertension Pharmacology
- Mitochondrial Function and Pathology
- Cancer-related molecular mechanisms research
- Healthcare and Venom Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Vagus Nerve Stimulation Research
- Respiratory Support and Mechanisms
- Adenosine and Purinergic Signaling
- Immune Response and Inflammation
- Neurosurgical Procedures and Complications
- Neuroinflammation and Neurodegeneration Mechanisms
- Inflammasome and immune disorders
- Medical Research and Treatments
- Sirtuins and Resveratrol in Medicine
- High Altitude and Hypoxia
- Cardiac Fibrosis and Remodeling
- Drug Transport and Resistance Mechanisms
- Electrochemical sensors and biosensors
- Traditional Chinese Medicine Analysis
- Environmental Quality and Pollution
Tianjin Medical University
2015-2025
Tianjin Nankai Hospital
2016-2025
Soochow University
2017-2025
The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)
2025
Second Affiliated Hospital of Soochow University
2025
Sichuan University
2024-2025
State Key Laboratory of Oral Diseases
2024-2025
Southwest University
2025
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Increasing lines of evidence identified that dexmedetomidine (DEX) exerted protective effects against sepsis-stimulated acute lung injury via anti-inflammation, anti-oxidation and anti-apoptosis. However, the mechanisms remain unclear. Herein, we investigated whether DEX afforded protection by regulating process mitochondrial dynamics through HIF-1a/HO-1 pathway in vivo vitro. Using C57BL/6J mice exposed to lipopolysaccharide, it was initially observed preemptive administration (50μg/kg)...
Sepsis-related acute lung injury (ALI) remains a major cause of mortality in critically ill patients and lacks specific therapy. Mitochondrial dysfunction is involved the progression septic injury. dynamics, mitophagy, biogenesis converge to constitute assiduous quality control mitochondria (MQC). Heme oxygenase-1 (HO-1) protects against sepsis-induced ALI through modulation mitochondrial dynamics. However, causal relationship between HO-1 general processes MQC, their associated cellular...
FAM3A belongs to a novel cytokine-like gene family, and its physiological role remains largely unknown. In our study, we found marked reduction of expression in the livers db/db high-fat diet (HFD)-induced diabetic mice. Hepatic overexpression markedly attenuated hyperglycemia, insulin resistance, fatty liver with increased Akt (pAkt) signaling repressed gluconeogenesis lipogenesis those contrast, small interfering RNA (siRNA)-mediated knockdown hepatic resulted hyperglycemia reduced pAkt...
Abstract Hypoxic pulmonary hypertension (PH) is a progressive disease characterized by hyper-proliferation of vascular cells including artery smooth muscle (PASMCs) and can lead to right heart failure early death. Selective degradation mitochondria mitophagy during hypoxia regulates mitochondrial functions in many cells, however, it not clear if involved the pathogenesis hypoxic PH. By employing receptor Fundc1 knockout (KO) transgenic (TG) mouse models, combined PH current study found that...
Progressive cardiac fibrosis leads to ventricular wall stiffness, dysfunction, and eventually heart failure, but the underlying mechanism remains unexplored. PDCD5 (programmed cell death 5) ubiquitously expresses in tissues, including heart; however, role of is largely unknown. Therefore, this study aims at exploring possible mechanisms pathogenesis fibrosis.PDCD5 levels were found be elevated serum obtained from patients with fibrosis, fibrotic mice tissues after myocardial infarction,...
Sepsis-associated acute lung injury remains the major cause of mortality in critically ill patients and is characterized by marked oxidative stress mitochondrial dysfunction. Mitochondrial dynamics are indispensable for functional integrity. Additionally, heme oxygenase (HO)-1/carbon monoxide conferred cytoprotection against end-organ damage during endotoxic shock. Herein, we tested hypothesis that HO-1/carbon played a critical role maintaining dynamic process fusion/fission to mitigate...
Acute kidney injury (AKI) is a substantial worldwide public health concern with no specific and effective therapies in clinic. NAD+ pivotal determinant of cellular energy metabolism involved the progression AKI; however, its mechanism remains poorly understood. Sirtuin 1 (SIRT1) an -dependent deacetylase associated renal protection acute stress resistance. In this study, we have investigated role AKI potential mechanism(s) renoprotective effect. was notably decreased negatively correlated...
ATP synthase β subunit (ATPSβ) had been previously shown to play an important role in controlling synthesis pancreatic β-cells. This study aimed investigate the of ATPSβ regulation hepatic content and glucose metabolism diabetic mice. expression were both reduced livers type 1 2 Hepatic overexpression elevated cellular ameliorated hyperglycemia streptozocin-induced mice db/db increased phosphorylated Akt (pAkt) levels PEPCK G6pase livers. Consistently, repressed production In cultured...
NF-E2 related factor 2 (Nrf2) is a major transcription and acts as key regulator of antioxidant genes to exogenous stimulations. The aim current study was determine whether Nrf2/ARE pathway involved in the protective effect electroacupuncture on injured lung rabbit model endotoxic shock. A dose lipopolysaccharide (LPS) 5 mg/kg administered intravenously replicate acute injury induced by Electroacupuncture pretreatment handled bilaterally at Zusanli Feishu acupoints for five consecutive days...
Abstract Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a common and important oxidative stress in the lung. Mitochondrial fusion responds to normal morphology function of cells finely regulated by mitochondrial proteins, such as mitofusin-1 protein (Mfn1), mitofusin-2 (Mfn2) optical atrophy 1 (OPA1). Additionally, Mfn1 has been identified most fusion. Heme oxygenase-1 (HO-1) stress-inducible that plays critical role protecting against stress. However, whether...
Sepsis-induced acute lung injury (ALI) is a severe condition with limited effective therapeutics; nicotinamide mononucleotide (NMN) has been reported to exert anti-inflammatory activities.This study explores the potential mechanisms by which NMN ameliorates sepsis-induced ALI in vivo and vitro.Cultured MH-S cells murine model were used evaluate effect of on ALI. stimulated LPS (1 μg/mL) (500 μM) for 12 h grouping as control, LPS, + NMN. Cell viability, apoptotic status, M1/2...
Endurance exercise triggers adaptive responses especially in slow-twitch myofibers of skeletal muscles, leading to the remodeling myofiber structure and mitochondrial network. However, molecular mechanisms underlying these responses, with a focus on fiber type-specific perspective, remains largely unknown. In this study we analyzed alterations transcriptomics metabolomics distinct response endurance exercise. We determined that genes associated sphingolipid metabolism, namely those encoding...
Autophagy including mitophagy serves as an important regulatory mechanism in the heart to maintain cellular homeostasis and protect against damages caused by myocardial infarction (MI). The current study aims dissect roles of general autophagy specific regulating cardiac function after MI. By using Beclin1+/- , Fundc1 knockout (KO) transgenic (TG) mouse models, combined with starvation MI we found that KO more severe mitochondrial dysfunction than Interestingly, notable decrease total...
Electroacupuncture at select acupoints have been verified to protect against organ dysfunctions during endotoxic shock. And, heme oxygenase (HO)-1 as a phase II enzyme and antioxidant contributed the protection of kidney in septic shock rats. The phosphatidylinositol 3-kinase (PI3K)-Akt pathway mediated activation NF-E2 related factor-2 (Nrf2), which was involved HO-1 induction. To understand efficacy electroacupuncture stimulation ameliorating acute injury (AKI) through PI3K/Akt/Nrf2...
Background . Endotoxin‐associated acute kidney injury (AKI), a disease characterized by marked oxidative stress and inflammation disease, is major cause of mortality in critically ill patients. Mitochondrial fission pyroptosis often occur AKI. However, the underlying biological pathways involved endotoxin AKI remain poorly understood, especially those related to mitochondrial dynamics equilibrium disregulation pyroptosis. Previous studies suggest that heme oxygenase‐ (HO‐) 1 confers...