A5100775192- Traditional Chinese Medicine Studies
- Pharmacological Effects of Natural Compounds
- Cancer-related molecular mechanisms research
- Acupuncture Treatment Research Studies
- Liver Disease Diagnosis and Treatment
- Healthcare and Venom Research
- Diet, Metabolism, and Disease
- Gut microbiota and health
- Adipose Tissue and Metabolism
- Heme Oxygenase-1 and Carbon Monoxide
- Diet and metabolism studies
- MicroRNA in disease regulation
- Medicinal Plant Pharmacodynamics Research
- Metabolism, Diabetes, and Cancer
- Natural Antidiabetic Agents Studies
- Circular RNAs in diseases
- RNA modifications and cancer
- Peroxisome Proliferator-Activated Receptors
- Pancreatic function and diabetes
- Natural product bioactivities and synthesis
- Medical Research and Treatments
- Mitochondrial Function and Pathology
- Connective Tissue Growth Factor Research
- Medicinal Plants and Bioactive Compounds
- Dietary Effects on Health
Beijing University of Chinese Medicine
2015-2025
Hebei Medical University
2009-2025
Fourth Hospital of Hebei Medical University
2009-2025
Tianjin Medical University
2014-2024
Shanghai Jiao Tong University
2010-2024
Tianjin Nankai Hospital
2014-2024
Fujian Medical University
2023-2024
Nanchang University
2024
Yunnan University of Traditional Chinese Medicine
2024
Fudan University
2024
Sepsis-related acute lung injury (ALI) remains a major cause of mortality in critically ill patients and lacks specific therapy. Mitochondrial dysfunction is involved the progression septic injury. dynamics, mitophagy, biogenesis converge to constitute assiduous quality control mitochondria (MQC). Heme oxygenase-1 (HO-1) protects against sepsis-induced ALI through modulation mitochondrial dynamics. However, causal relationship between HO-1 general processes MQC, their associated cellular...
Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) is the leading cause of chronic that affects over 30% world’s population. For decades, heterogeneity non-alcoholic fatty (NAFLD) has impeded our understanding mechanism and development effective medications. However, a recent change in nomenclature from NAFLD to MASLD emphasizes critical role systemic metabolic dysfunction pathophysiology this therefore promotes progress pharmaceutical treatment MASLD. In review, we...
Abstract Berberine (BBR), an isoquinoline alkaloid derived from plants, is widely used as anti-inflammatory remedy in traditional Chinese medicine. In this study, we showed that BBR was efficacious the amelioration of experimental autoimmune encephalomyelitis (EAE) through novel regulatory mechanisms involving pathogenic Th1 and Th17 cells. inhibited differentiation cells and, to a lesser degree, direct actions on JAK/STAT pathway, whereas it had no effect relative number CD4+Foxp3+ T...
Chronic infection with hepatitis B virus (HBV) often causes chronic inflammation of the liver an increased incidence hepatocellular carcinoma (HCC). HBV-infected individuals may also have nonliver cancers. Taking statin or metformin decrease and infiltration, which may, as a result, reduce risk cancer other major cancers in patients HBV infection. The purpose this study was to evaluate hypothesis that could (HCC) HBV. Using Taiwan Longitudinal Health Insurance Database 2000 2008, cohort...
Abstract Filamentous prophages are widespread among bacteria and play crucial functions in virulence, antibiotic resistance, biofilm structures. The filamentous Pf4 particles, extruded by an important pathogen Pseudomonas aeruginosa, can protect producing cells from adverse conditions. Contrary to the conventional belief that Pf4-encoding resist reinfection, we herein report prophage is reciprocally commonly exchanged within P. aeruginosa colonies, which repair defective community. By...
To investigate the effects of cinnamaldehyde (CA), an active and major compound in cinnamon, on glucose metabolism insulin resistance C57BLKS/J db/db mice.Sixteen male C57BLKS mice were randomly divided into control CA treatment groups. was given (20 mg x kg(-1) day(-1), p. o.) for 4 weeks. Pure water to db/+ mice. Subsequently, levels fasting blood (FBG), serum insulin, triglyeride, cholesterol, low-density lipoprotein-cholesterol (LDL-C), high-density (HDL-C), free fatty acids (FFA), as...
NF-E2 related factor 2 (Nrf2) is a major transcription and acts as key regulator of antioxidant genes to exogenous stimulations. The aim current study was determine whether Nrf2/ARE pathway involved in the protective effect electroacupuncture on injured lung rabbit model endotoxic shock. A dose lipopolysaccharide (LPS) 5 mg/kg administered intravenously replicate acute injury induced by Electroacupuncture pretreatment handled bilaterally at Zusanli Feishu acupoints for five consecutive days...
Panax notoginseng saponins ( PNS ) are a commonly used traditional medicine to treat diabetes in China. Recent studies have confirmed their anti‐diabetic effects, but the underlying mechanisms remained unclear. The present study was designed explore whether decrease hyperglycemia by improving insulin sensitivity skeletal muscle and elucidate molecular mechanisms. effects of were analyzed myoblast cell line, C2C12, high fat diet‐induced diabetic KKA y mice. C2C12 cells treated with (50, 100,...
This study presents a systematic meta-analysis of the correlation between Helicobacter pylori (H. pylori) infection and autoimmune thyroid diseases (AITD).Fifteen articles including 3,046 cases were selected (1,716 observational 1,330 control cases). These data analyzed using Stata12.0 software.H. was positively correlated with occurrence AITD (OR = 2.25, 95% CI: 1.72-2.93). Infection H. strains positive for cytotoxin-associated gene A (CagA) 1.99, 1.07-3.70). There no significant difference...
Abstract Lysyl oxidase‐like 2 ( LOXL 2) has shown to promote metastasis and poor prognosis in hepatocellular carcinoma HCC ). Also, we have previously reported that vasculogenic mimicry VM ) is associated with invasion, survival patients. In the present study, investigated molecular function of . We used immunohistochemical CD 31/periodic acid‐Schiff double staining detect relationship between formation. performed gain loss studies analysed migratory, invasion tube formation cell lines. both...
Metabolic disorders represent a major therapeutic challenge to public health worldwide due their dramatically increasing prevalence. Acupuncture is widely used as adjuvant therapy for multiple metabolic diseases. However, detailed biological interpretation of the acupuncture stimulations still limited. The gut and liver are intrinsically connected related function. Microbial metabolites might affect gut-liver axis through mechanisms. Liver metabolomics 16S rRNA sequencing were explore...
In the field of cancer therapy, inhibiting autophagy has emerged as a promising strategy. However, pharmacological disruption can lead to upregulation programmed death-ligand 1 (PD-L1), enabling tumor immune evasion. To address this issue, we developed innovative ROS-responsive cationic poly(ethylene imine) (PEI) nanogels using selenol chemistry-mediated multicomponent reaction (MCR) technology. This procedure involved simple mixing low-molecular-weight PEI (LMW PEI), γ-selenobutylacetone...