A5066292528- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Angiogenesis and VEGF in Cancer
- Wnt/β-catenin signaling in development and cancer
- Cancer Mechanisms and Therapy
- Cell death mechanisms and regulation
- FOXO transcription factor regulation
- Advanced biosensing and bioanalysis techniques
- Cancer-related Molecular Pathways
- Cancer-related gene regulation
- Endoplasmic Reticulum Stress and Disease
- Viral-associated cancers and disorders
- Epigenetics and DNA Methylation
- Magnolia and Illicium research
- Ubiquitin and proteasome pathways
- Circular RNAs in diseases
- Microtubule and mitosis dynamics
- Cancer, Hypoxia, and Metabolism
- Lymphoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Rheumatoid Arthritis Research and Therapies
- PI3K/AKT/mTOR signaling in cancer
- Advanced Nanomaterials in Catalysis
Peking University Shenzhen Hospital
2021-2025
Hong Kong University of Science and Technology
2021-2025
University of Hong Kong
2023-2025
University of Hong Kong - Shenzhen Hospital
2021-2024
University Town of Shenzhen
2024
Guangdong Pharmaceutical University
2023
Guangdong Medical College
2023
Fujian Provincial Cancer Hospital
2019-2022
Fujian Medical University
2015-2022
Shenzhen Institutes of Advanced Technology
2021-2022
Abstract MYH9 has dual functions in tumors. However, its role inducing tumor stemness hepatocellular carcinoma (HCC) is not yet determined. Here, we found that an effective promoter of facilitates pathogenesis. Importantly, targeting remarkably improved the survival carcinoma-bearing mice and promoted sorafenib sensitivity cells vivo. Mechanistic analysis suggested interacted with GSK3β reduced protein expression by ubiquitin-mediated degradation, which therefore dysregulated β-catenin...
Agents that target angiogenesis have shown limited efficacy for human triple-negative breast cancer (TNBC) in clinical trials. Along with endothelium-dependent vessels, there is also vasculogenic mimicry (VM) the microcirculation of malignant tumors. The role VM not completely understood regarding anti-angiogenic treatment. In this study, TNBC MDA-MB-231 and Hs578T non-TNBC MCF-7 BT474 tumor-bearing mice were treated sunitinib, an drug, using a clinically relevant schedule. drug was...
Purpose: This study was performed to identify the detailed mechanisms by which miR-296-3p functions as a tumor suppressor prevent lung adenocarcinoma (LADC) cell growth, metastasis, and chemoresistance.Experimental Design: The expression examined real-time PCR in situ hybridization. MTT, EdU incorporation, Transwell assays, MTT cytotoxicity were respectively for proliferation, chemoresistance; Western blotting analyze pathways HDGF/DDX5 complex. miRNA microarray luciferase reporter assays...
Cancer stem cells (CSCs) are the key factor in determining cancer recurrence, metastasis, chemoresistance and patient prognosis hepatocellular carcinoma (HCC).The role of miR-5188 stemness has never been documented.In this study, we investigated clinical biological roles HCC.Methods: MiRNA expression HCC was analyzed by bioinformatics analysis situ hybridization.The effect demonstrated both vitro vivo studies through ectopic miR-5188.The target gene molecular pathway were characterized using...
Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-related tumor. The role of EBV-encoding miR-BART22 still unclear in NPC. This study aimed to identify the detailed mechanisms by which EBV-miR-BART22 functions as a tumor-promoting factor and evaluate action cinobufotalin treating EBV-miR-BART22-overexpressing NPC cells.Using real-time PCR, western blotting, immunohistochemistry, In situ hybridization, we detected expression MAP2K4 tissues cells, well evaluated their clinical...
Stemness and chemoresistance contribute to cervical cancer recurrence metastasis. In the current study, we determined relevant players role of N6-methyladenine (m6A) RNA methylation in progression.The roles m6A centromere protein K (CENPK) were analyzed using bioinformatics analysis. Methylated immunoprecipitation was adopted detect modification CENPK mRNA. Human clinical samples, cell lines, xenografts used for analyzing gene expression function. Immunofluorescence staining tumorsphere...
Abstract MiR-374a appears to play a complex role in non-small-cell lung cancer (NSCLC). Here, we demonstrate dual for miR-374a NSCLC pathogenesis. The effects and modulatory mechanisms of on cell growth, migration, invasion, vivo tumorigenesis metastasis nude mice were also analyzed. expression was examined non-cancerous tissues by quantitative real-time reverse transcription-PCR (qRT-PCR), situ hybridization, respectively. directly targets CCND1 inactivates PI3K/AKT Ras-mediated cycle...
Abstract In this study, we present novel molecular mechanisms by which FOXO1 functions as a tumor suppressor to prevent the pathogenesis of nasopharyngeal carcinoma (NPC). First, observed that not only controlled stemness and metastasis, but also sensitized NPC cells cisplatin (DDP) in vitro vivo. Mechanistic studies demonstrated FOXO1-induced miR-200b expression through GSK3β/β-catenin/TCF4 network-mediated stimulation ZEB1, reduced epithelial–mesenchymal transition (EMT) signal....
MicroRNAs (miRNAs) play an essential role in the self-renewal of breast cancer stem cells (BCCs). Our study aimed to clarify proto-oncogene c-Jun-regulated miR-5188 progression and its association with Timeless-mediated stemness. In present study, we showed that exerted oncogenic effect by inducing stemness, proliferation, metastasis, chemoresistance vitro vivo. The mechanistic analysis demonstrated directly targeted FOXO1, which interacted β-catenin cytoplasm, facilitated degradation,...
Abstract Rheumatoid arthritis (RA) is an inflammatory autoimmune disease, and RA interstitial lung disease (ILD) a severe complication of RA. This investigation aims to determine the effect underlying mechanism osthole (OS), which could be extracted from Cnidium , Angelica Citrus plants evaluate role transglutaminase 2 (TGM2) in RA‐ILD. In this work, OS downregulated TGM2 exert its additive with methotrexate suppress proliferation, migration, invasion RA‐fibroblast‐like synoviocytes (FLS) by...
Cisplatin (cDDP) is effective against some human tumors, but many are intrinsically resistant and, even among initially sensitive acquired resistance develops commonly during treatment. It has not been possible to prove which biochemical mechanisms control sensitivity cDDP. Gene knockout studies in yeast, Dictyostelium discoideum, and mammalian cells have begun unambiguously identify genes whose products function modulate the cytotoxicity of This review summarizes information currently...
Vasculogenic mimicry (VM), a newly defined pattern of tumor blood supply, describes the functional plasticity aggressive cancer cells that form vascular networks. In our previous study, breast stem (CSC) were shown to potentially participate in VM formation. this CSCs presented centrosome amplification (CA) phenotype and ubiquitin-specific protease 44 (USP44) upregulation. USP44 expression contributed establishment bipolar spindles with supernumerary centrosomes by localizing at...
microRNA-374a (miR-374a) exhibits oncogenic functions in various tumor types. Here we report that miR-374a suppresses proliferation, invasion, migration and intrahepatic metastasis colon adenocarcinoma cell lines HCT116 SW620. Notably, detected PI3K/AKT signaling its downstream cycle factors including c-Myc, cyclin D1 (CCND1), CDK4 epithelial-mesenchymal transition (EMT)-related genes ZEB1, N-cadherin, Vimentin, Slug, Snail were all significantly downregulated after overexpression....
Sphere formation in conditioned serum‐free culture medium supplemented with epidermal growth factor and basic fibroblast (tumorospheres) is considered useful for the enrichment of cancer stem‐like cells, also known as tumor‐initiating cells. We used a gene expression microarray to investigate profile melanoma cells ( MCSLC s). The results showed that s highly expressed following Notch signaling pathway molecules: Notch3 NM _008716), Notch4 _010929), Dtx4 _172442), JAG 2 _010588)....
We report that all- trans retinoic acid (ATRA) enhanced the toxicity of docetaxel against DU145 and LNCaP prostate cancer cells, nature interaction between ATRA was highly synergistic. Docetaxel-induced apoptotic cell death associated with phosphorylation hence inactivation Bcl-2. docetaxel-induced apoptosis combined treatment resulted in down-regulation Docetaxel caused cdc2 kinase result ing G2/M arrest. inhibited resulting activation partial reversal also MAPK indicating effects on are...
Vasculogenic mimicry (VM) is a nonangiogenesis-dependent pathway that promotes tumor growth and disease progression. Nodal signaling has several vital roles in both embryo development cancer However, the effects of on VM formation breast its underlying mechanisms are ill-defined. We analyzed relationship between one hundred human cases results showed expression was significantly correlated with formation, metastasis, differentiation grade, TNM stage poor prognosis. Furthermore, up-regulation...
Abstract Lysyl oxidase‐like 2 ( LOXL 2) has shown to promote metastasis and poor prognosis in hepatocellular carcinoma HCC ). Also, we have previously reported that vasculogenic mimicry VM ) is associated with invasion, survival patients. In the present study, investigated molecular function of . We used immunohistochemical CD 31/periodic acid‐Schiff double staining detect relationship between formation. performed gain loss studies analysed migratory, invasion tube formation cell lines. both...
Abstract Angiogenesis in solid tumors is divided into two modes: endothelium-dependent vessel (EDV) and vasculogenic mimicry (VM). Sphingosine-1-phosphate receptor 1 (S1PR1) plays a vital role on EDV variety of human tumors. However, the relationship between S1PR1 VM not clear. The aim this study to investigate regulation formation breast cancer. Here we show that phosphorylates complex VE-cadherin regulate switch formation. Suppression impairs EDV, but contributes generation VM, invasion,...
Rheumatoid arthritis (RA) is a chronic autoimmune disease. We previously revealed that the natural compound artemisitene (ATT) exhibits excellent broad anticancer activities without toxicity on normal tissues. Nevertheless, effect of ATT RA undiscovered. Herein, we aim to study and potential mechanism management.A collagen-induced (CIA) mouse model was employed confirm anti-RA ATT. Cell Counting Kit-8 (CCK-8) 5-ethynyl-2'-deoxyuridine (EdU) assays, cell cycle apoptosis analysis,...