A5019628417- Plant-Microbe Interactions and Immunity
- Plant Molecular Biology Research
- Pregnancy and preeclampsia studies
- Plant Virus Research Studies
- Immune Response and Inflammation
- Plant Stress Responses and Tolerance
- Glaucoma and retinal disorders
- Photosynthetic Processes and Mechanisms
- Natural product bioactivities and synthesis
- Pharmacological Effects of Natural Compounds
- Cancer, Stress, Anesthesia, and Immune Response
- Plant Physiology and Cultivation Studies
- Plant Disease Resistance and Genetics
- Traditional Chinese Medicine Analysis
- Obsessive-Compulsive Spectrum Disorders
- Genetic Mapping and Diversity in Plants and Animals
- Plant and Fungal Interactions Research
- Plant Gene Expression Analysis
- Ginseng Biological Effects and Applications
- Ocular Diseases and Behçet’s Syndrome
- NF-κB Signaling Pathways
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Uterine Myomas and Treatments
- Retinal Diseases and Treatments
Nanjing Agricultural University
2019-2024
Shandong Provincial Hospital
2012-2024
Cornell University
2017-2024
Dalian Medical University
2015-2024
Air Force Medical University
2019-2024
Shandong First Medical University
2022-2024
Cangzhou Central Hospital
2014-2023
Chengde Medical University
2013-2023
Shanghai Jiao Tong University
2021-2023
First Affiliated Hospital of Henan University
2015-2023
Abstract Astragalus polysaccharides (APS), which is widely used as a remedy to promote immunity of breast cancer patients, can enhance immune responses and exert anti-tumor effects. In this study, we investigated the effects mechanisms APS on macrophage RAW 264.7 EAC tumor-bearing mice. Griess reaction ELISA assays revealed that concentrations nitric oxide, TNF-α, IL-1β IL-6 were increased by APS. However, effect was diminished in presence TAK-242 (TLR4 inhibitor) or ST-2825(MyD88...
Plant immune responses need to be tightly controlled for growth-defense balance. The mechanism underlying this tight control is not fully understood. Here we identify epigenetic regulation of nucleotide-binding leucine rich repeat or Nod-Like Receptor (NLR) genes as an important responses. Through a sensitized genetic screen and molecular studies, identified characterized HOS15 its associated protein HDA9 negative regulators immunity NLR gene expression. loss-of-function confers enhanced...
Rice blast is one of the most devastating diseases, causing a significant reduction in global rice production. Developing and utilizing resistant varieties has proven to be efficient cost-effective approach control blasts. However, due environmental pressure intense pathogenic selection, resistance rapidly broken down, more durable genes are being discovered. In this paper, novel wall-associated kinase (WAK) gene, Pb4, which confers blast, was identified through genome-wide association study...
Polysaccharopeptide (PSP), isolated from Coriolus versicolor COV-1 strain, is a protein-bound polysaccharide widely used as immunoadjuvant for cancer immunotherapy. Although the immunomodulatory activity of PSP has been well established, precise molecule mechanisms its biological have yet to be fully elucidated.In present study, we first investigated in peritoneal macrophages C57BL/10J (TLR4(+/+)) and C57BL/10ScCr (TLR4(-/-)) mice carrying defective toll-like receptor-4 (TLR4) gene then...
Summary Emerging evidence indicates a close connection between cell‐cycle progression and the plant immune responses. In Arabidopsis, MODIFIER OF snc1‐1 ( MOS 1 ) modulates number of processes including endoreduplication disease resistance, but molecular mechanism underlying this modulation was not fully understood. Here, we provide biochemical genetic that TEOSINTE BRANCHED 1, CYCLOIDEA , PCF TCP transcription factors 15 its homologues are mediators function in response likely to be also...
Long non-coding RNA growth arrest-specific 5 (GAS5) has been demonstrated to be involved in the pathogenesis of atherosclerosis (AS). The purpose present study was investigate underlying mechanisms GAS5 on inflammation and lipid metabolic disorders AS. ApoE-/- mice were fed a high fat diet (HFD) THP-1 macrophages treated with ox-LDL construct AS model vivo vitro, respectively. detections blood lipids inflammatory cytokines performed using corresponding assay kits. qRT-PCR used assess...
Summary The SAUR26 subfamily genes play an important role in conferring variations of thermo‐responsiveness growth architecture among natural accessions Arabidopsis thaliana . expression are critical for their activity variations, but how generated is unknown. We identified genetic loci gene through genome‐wide association study (eGWAS) and investigated mechanisms molecular analyses. found that cis elements the major determinants , SAUR27 SAUR28 Polymorphisms promoter region likely impact...
Mitochondrial fission and fusion are important for mitochondrial function, dynamin 1-like protein (DNM1L) is a key regulator of fission. We investigated the effect on function inflammation in fibroblast-like synoviocytes (FLSs) during rheumatoid arthritis (RA). DNM1L expression was determined synovial tissues (STs) from RA non-RA patients. FLSs were isolated STs treated with inhibitor (mdivi-1, division 1) or transfected DNM1L-specific siRNA. morphology, expression, cell viability, membrane...
Primary metabolism provides energy for growth and development as well secondary metabolites diverse environmental responses. Here we describe an unexpected consequence of disruption a glycolytic enzyme enolase named LOW EXPRESSION OF OSMOTICALLY RESPONSIVE GENE 2 (LOS2) in causing constitutive defense responses or autoimmunity Arabidopsis thaliana. The the los2 mutant is accompanied by higher expression about one-quarter intracellular immune receptor nucleotide-binding leucine-rich repeat...
This study was performed to explore the effect of aortic arch type on technical indicators in patients undergoing carotid artery stenting (CAS).The data 224 consecutive who underwent unilateral CAS from January 2011 December 2012 were retrospectively analyzed. The requirement for placement guiding catheter into common with assistance an angiographic catheter, fluoroscopy time, contrast agent dose, and adverse events recorded.The time significantly longer dose higher Type III than I II...
Plant intracellular immune receptor NLR (nucleotide-binding leucine-rich repeat) proteins sense the presence of pathogens and trigger strong robust responses. genes are known to be tightly controlled at protein level, but little is about their dynamics transcript level. In this study, we presented a meta-analysis all 207 in Col-0 accession Arabidopsis thaliana under various biotic abiotic stresses based on 88 publicly available RNA sequencing datasets from 27 independent studies. We find...
Rice blast is a worldwide fungal disease that seriously affects the yield and quality of rice. Identification resistance genes against rice one effective ways to control this disease. However, panicle genes, which are useful in fields, have rarely been studied due difficulty phenotypic identification environmental influences. Here, resistance-3 (Pb3) was identified by genome-wide association study (GWAS) based on phenotypes 230 Diversity Panel I (RDP-I) accessions with 700,000...
How diversity in growth thermo-responsiveness is generated for local adaptation a long-standing biological question. We investigated molecular genetic basis of natural variations plant architecture Arabidopsis thaliana. measured the extent rosette at 22°C and 28°C set 69 accessions determined their architecture. A genome-wide association study was performed to identify major loci thermo-responsiveness. The SAUR26 subfamily, new subfamily SAUR genes, identified as locus thermo-responsive...