A5100438262- Plant Gene Expression Analysis
- Plant tissue culture and regeneration
- Horticultural and Viticultural Research
- Nanoplatforms for cancer theranostics
- Cancer Immunotherapy and Biomarkers
- Phytochemicals and Antioxidant Activities
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- Plant Pathogens and Fungal Diseases
- Medical Imaging and Pathology Studies
- Photodynamic Therapy Research Studies
- Angiogenesis and VEGF in Cancer
- Inflammasome and immune disorders
- CAR-T cell therapy research
- Analytical Chemistry and Sensors
- Schizophrenia research and treatment
- Occupational and environmental lung diseases
- Pregnancy-related medical research
- Allelopathy and phytotoxic interactions
- Family Caregiving in Mental Illness
- Geophysical and Geoelectrical Methods
- Pineapple and bromelain studies
- Mycobacterium research and diagnosis
- Peanut Plant Research Studies
Sichuan University
2019-2024
West China Hospital of Sichuan University
2022-2024
Sichuan Agricultural University
2018-2024
Universitätsklinikum Aachen
2023
Army Medical University
2022
Xinqiao Hospital
2022
Guiyang Medical University
2022
State Key Laboratory of Biotherapy
2020-2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2021
Huazhong Agricultural University
2021
Silicosis caused by inhalation of silica particles leads to more than ten thousand new occupational exposure-related deaths yearly. Exacerbating this issue, there are currently few drugs reported effectively treat silicosis. Tetrandrine is the only drug approved for silicosis treatment in China, and despite decades use, its efficacy mechanisms action remain largely unknown. Here, study, we established mouse models investigate effectiveness tetrandrine early late therapeutic administration....
Abstract The adenoma-carcinoma sequence is a well-accepted roadmap for the development of sporadic colorectal cancer. However, cellular heterogeneity in aberrant epithelial cells limits our understanding carcinogenesis tissues. Here, we performed single-cell RNA sequencing survey 54,788 from patient-matched tissue samples, including blood, normal tissue, para-cancer, polyp, and At each stage carcinogenesis, characterized cell types, transcriptional signatures, differentially expressed genes...
Rationale: Silicosis is a severe occupational lung disease. Current treatments for silicosis have highly limited availability (i.e., transplantation) or, do not effectively prolong patient survival time lavage). There thus an urgent clinical need effective drugs to retard the progression of silicosis. Methods: To systematically characterize molecular changes associated with and discover potential therapeutic targets, we conducted transcriptomics analysis human tissues acquired during...
Background: Caffeic Acid Phenethyl Ester (CAPE), an active extract of propolis, has recently been reported to have broad applications in various cancers. However, the effects CAPE on Small Cell Lung Cancer (SCLC) are largely unknown. Therefore, aim this study was determine anti-proliferative effect and explore underlying molecular mechanisms SCLC cells using high-throughput sequencing bioinformatics analysis. Methods: Small-cell lung cancer H446 were treated with CAPE, cell proliferation...
The combination of MAPK-targeted therapy and immune checkpoint blockade is one the most promising regimens for patients with advanced melanoma. However, synergistic efficacy combo regimen still controversial in clinical trials. Here, we report that MAPK inhibition induced T-cell suppression within tumor microenvironment mediated by attenuation HSP27/HSP70 deficiency neoantigen presentation. To address this problem, designed a photothermal-responsive on-demand controlled drug release gold...
Abstract The combination of BRAF/MEK‐targeted therapy with immune checkpoint blockade is regarded as a promising regimen for patients metastatic melanoma due to their complementary advantages. However, MEK‐inhibitor‐induced T‐cell toxicity impedes effective cooperation. In this experiment, pH‐responsive on‐demand controlled release mesoporous silica nanoparticles (MSNPs) system designed. Fluorescein‐isothiocyanate‐loaded MSNP can be specifically delivered into tumor cells rather than...
Silicosis is a fatal occupational lung disease which currently has no effective clinical cure. Recent studies examining the underlying mechanism of silicosis have primarily examined experimental models, may not perfectly reflect nature human progression. A comprehensive profiling molecular changes in lungs urgently needed. Here, we conducted RNA sequencing (RNA-seq) on tissues 10 patients and 7 non-diseased donors. total 2,605 differentially expressed genes (DEGs) critical pathway were...
Chinese cherry (Cerasus pseudocerasus (Lindl.) G.Don) is an economically important tetraploid fruiting species native to China. Simple sequence repeats (SSRs)—due their codominance, polymorphism, and stability—have been widely applied in genetic identification trait-association analysis. In this study, using comparative genomics strategy the data of one high-quality whole genome seven preliminarily assembled sequences, we constructed a database containing 25,779 polymorphic SSR loci...
As a hallmark of cancer, angiogenesis plays pivotal role in carcinogenesis. However, the correlation between and evolution BRAFV600E kinase inhibitor‒acquired resistance is still poorly understood. In this study, we reported that molecular signatures were enriched early on-treated biopsies but not disease-progressed biopsies. The process drug development was accompanied by remodeling vascular morphology, which potentially manipulated tumor-secreted proangiogenic factors. Further...
Methamphetamine (METH), a psychostimulant, has the potential to cause neurodegeneration by targeting cerebrum and cerebellum. It been suggested that NLRP3 inflammasome may be responsible for neurotoxicity caused METH. However, role of in METH-induced cerebellar Purkinje cell (PC) degeneration underlying mechanism remain elusive. This study aims determine consequences modulation chronic PC degeneration. In METH mice models, increased expression, degeneration, myelin sheath destruction, axon...
Platelet-fibrin clot contraction is critical for wound closure and maintenance of vessel patency, yet a molecular understanding the process has lagged because lack flexible quantitative assay systems capable assaying multiple samples simultaneously.
Background MicroRNAs (miRNAs) play a vital role in tuberculosis (TB). Vitamin D receptor (VDR), an miRNA target gene, and its ligand, vitamin 3 (VitD ), have been reported to exert protective effects against TB. However, whether miRNAs can affect the progression of TB by targeting VDR has not reported. Materials methods Research subjects were selected according defined inclusion criteria. A clinical database 360 samples was established, including subjects’ demographic information, expression...
Abstract Aim This study aimed to establish a comprehensive set of recovery‐oriented rehabilitation programs for individuals with schizophrenia, comparing the efficacy video‐based traditional face‐to‐face interventions. The primary objective was assess whether could serve as viable alternative schizophrenia residing in remote areas. Methods A randomized controlled used recruit 80 patients stable post‐hospitalization stage following discharge. Participants were categorized into three groups:...
Objective: The study is to establish the key techniques of tissue culture Lavandula angustifolia L. Method: Using stem with buds as explant, effect disinfection time on contamination rate, types and ratio plant regulator propagation index rooting, transplanting substance plantlet survival rate were studied. Results conclusion: proper 0.1 % HgCl2 was 15min, by which plantlets respectively 83.3 25.0 %; MS +1.0mg/L BA + 0.3 mg/L IBA medium for propagation, 4.92; White 0.4 NAA rooting average...