A5101427092- Research in Cotton Cultivation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Plant Virus Research Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Plant Molecular Biology Research
- RNA modifications and cancer
- Biomarkers in Disease Mechanisms
- Inflammasome and immune disorders
- Chromosomal and Genetic Variations
- Plant biochemistry and biosynthesis
- Pediatric health and respiratory diseases
- Electric Motor Design and Analysis
- CRISPR and Genetic Engineering
- Cocoa and Sweet Potato Agronomy
- Ferroptosis and cancer prognosis
- Advanced Drug Delivery Systems
- Asthma and respiratory diseases
- Advancements in Transdermal Drug Delivery
- Plant tissue culture and regeneration
- Essential Oils and Antimicrobial Activity
- Studies on Chitinases and Chitosanases
- Respiratory Support and Mechanisms
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
Nanjing Agricultural University
2024-2025
Harbin Medical University
2013-2024
Second Affiliated Hospital of Harbin Medical University
2013-2024
Anyang Institute of Technology
2020-2023
Zhengzhou University
2020-2023
State Key Laboratory of Cotton Biology
2020-2021
Affiliated Hospital of Jining Medical University
2018
Shanghai Normal University
2014
Liaoning Provincial People's Hospital
2012
Silicosis caused by inhalation of silica particles leads to more than ten thousand new occupational exposure-related deaths yearly. Exacerbating this issue, there are currently few drugs reported effectively treat silicosis. Tetrandrine is the only drug approved for silicosis treatment in China, and despite decades use, its efficacy mechanisms action remain largely unknown. Here, study, we established mouse models investigate effectiveness tetrandrine early late therapeutic administration....
Pulmonary fibrosis is an irreversible chronic progressive fibroproliferative lung disease, which usually has a poor prognosis. Previous studies have confirmed that the transplantation of bone marrow mesenchymal stem cells (MSCs) significantly reduces damage in number animal models. However, underlying mechanism involved this process remains to be elucidated. In present study, bleomycin (BLM)‑induced female Wister rat model was established. At 0 or 7 days following BLM administration, rats...
Background: In recent years, a large number of studies have shown that differentially expressed lncRNAs are capable promoting the occurrence and development tumors by regulating cell proliferation differentiation. However, biological effects in non-small lung cancer (NSCLC) still needed to be further investigated. Methods: The NSCLC tissues downloaded profiles from GEO database were analyzed verified 100 pairs samples collected our hospital. After identification target gene MIR210HG,...
Silicosis is a leading cause of occupational disease-related morbidity and mortality worldwide, but the molecular basis underlying its development remains unclear. An accumulating body evidence supports gasdermin D (GSDMD)-mediated pyroptosis as key component in various pulmonary diseases. However, there little experimental connecting silicosis GSDMD-driven pyroptosis. In this work, we investigated role GSDMD-mediated silicosis. Single-cell RNA sequencing healthy human murine lung tissues...
Increasing soil salinization has led to severe losses of plant yield and quality. Thus, it is urgent investigate the molecular mechanism salt stress response. In this study, we took systematically analyzed cotton root response by single-cell transcriptomics technology; 56,281 high-quality cells were totally obtained from 5-days-old lateral tips Gossypium arboreum under natural growth different salt-treatment conditions. Ten cell types with an array novel marker genes synthetically identified...
Profiling of open chromatin is essential for understanding regulatory mechanisms that govern DNA-templated events. However, methodology-dependent detection sites (OCSs) has been reported in both humans and plants. Therefore, there a pressing need any reliable orthogonal methodologies to broaden the identification across genome, particularly We here report development an situ DNase I hypersensitivity sequencing (ISDH-seq) efficient characterization chromatin, which can be applicable 50-200 K...
Transdermal drug delivery of local anesthetics using lipid nanoparticles could enhance lipophilic drugs permeation through the stratum corneum, improve diffusion to deeper skin, and exert good therapeutic effects. The purpose this study was engineer a Tocopheryl Polyethylene Glycol 1000 Succinate (TPGS)-modified cationic nanostructured carriers (NLC) for lidocaine (LID; TPGS/LID-NLC).TPGS/LID-NLC prepared by solvent method. particle size, polydispersity index, zeta potential, entrapment...
The enzyme myo-inositol oxygenase (MIOX) catalyzes the into glucuronic acid. In this study, 6 MIOX genes were identified from all of three diploid cotton species (Gossypium arboretum, Gossypium herbaceum and raimondii) Gossypioides kirkii, 12 two domesticated tetraploid cottons hirsutum, barbadense, 11 wild tomentosum, mustelinum darwinii. number in genome is roughly twice that genome. Members family classified six groups based on phylogenetic analysis. Integrated analysis collinearity...
Abstract Background The development of cotton fiber is regulated by the orchestrated binding regulatory proteins to cis -regulatory elements associated with developmental genes. cis–trans dynamics occurred throughout course are elusive. Here we generated genome-wide high-resolution DNase I hypersensitive sites (DHSs) maps understand mechanisms ovule and development. Results We site (DHS) profiles from ovules at 0 3 days post anthesis (DPA) fibers 8, 12, 15, 18 DPA. obtained a total 1185...
Golden2-Like (GLK) transcription factors are a type of transcriptional regulator in plants. They play pivotal role the plant physiological activity process and abiotic stress response.In this study, potential function GLK family genes Gossypium hirsutum was studied based on genomic identification, phylogenetic analysis, chromosome mapping cis-regulatory elements prediction. Gene expression nine key were analyzed by qRT-PCR experiments.Herein, we identified total 146 GhGLK hirsutum, which...
A previous study indicated that LIM domain containing 2 (LIMD2) is an oncogene in a variety of human cancers, including breast, bladder and thyroid melanoma; however, the role LIMD2 non‑small cell lung cancer (NSCLC) remains largely unknown. In present study, by reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) analysis, it was demonstrated significantly upregulated NSCLC tissues compared with adjacent normal tissues. Consistently, also lines. Furthermore, reported...
Cotton is an excellent model for studying crop polyploidization and domestication. Chromatin profiling helps to reveal how histone modifications are involved in controlling differential gene expression between A D subgenomes allotetraploid cotton. However, the detailed functional characterization of broad H3K4me3 H3K27me3 still understudied In this study, we conducted H3K4me3- H3K27me3-related ChIP-seq followed by comprehensively characterizing their roles regulating transcription We found...
Abstract Single-stranded DNA (ssDNA) is essential for various DNA-templated processes in both eukaryotes and prokaryotes. However, comprehensive characterizations of ssDNA still lag plants compared to nonplant systems. Here, we conducted situ S1-sequencing, with starting gDNA ranging from 5 µg 250 ng, followed by rice (Oryza sativa L.). We found that loci were substantially associated a subset non-B structures functional genomic loci. Subtypes had distinct epigenetic features. Importantly,...
Abstract Background The emergence of chemoresistance markedly compromised the treatment efficiency human cancer, including non‐small cell lung cancer (NSCLC). In present study, we aimed to explore effects ubiquitin‐specific peptidase 22 (USP22) and murine double minute 2 (MDM2) in gefitinib resistance NSCLC. Methods Immunohistochemistry (IHC) assay, quantitative real‐time polymerase chain reaction (qRT‐PCR) assay western blot were carried out determine expression USP22 MDM2. Transwell flow...
Genetic factors play a role in the development and severity of chronic obstructive pulmonary disease (COPD). The pathogenesis COPD is multifactorial process including an inflammatory cell profile. Recent studies revealed that single nucleotide polymorphisms (SNPs) within ADAM33 increased susceptibility to through changing airway lung function. In this paper, we investigated associations four (T1, T2, S2 Q-1) as well their haplotypes with function East Asian population patients COPD. We found...
Phosphoenolpyruvate carboxylase (PEPC) is an important enzyme in plants, which regulates carbon flow through the TCA cycle and controls protein oil biosynthesis. Although it important, there little research on PEPC cotton, most fiber crop world. In this study, a total of 125 PEPCs were identified 15 Gossypium genomes. All genes cotton are divided into six groups each group generally contains one member diploid two tetraploid cotton. This suggests that already existed before their divergence....
The human leukocyte antigen HLA ‐A*31:22 allele shows a single nucleotide change at position 245 (A > C) of exon 2 from the closest matching ‐A*31:01:02 .
Abstract Background: The enzyme myo-inositol oxygenase (MIOX) catalyzes the into glucuronic acid. Previous studies indicated that MIOX may play an important role in plant responses to abiotic stresses. Cotton is a major source of natural and renewable textile. However, gene family cotton has not been systematically identified characterized yet. Results: In this study, 6 genes were from all three diploid species ( Gossypium arboretum , herbaceum raimondii ), 12 two domesticated tetraploid...
Objective To study the prevalence and risk factors of chronic obstructive pulmonary disease (COPD),and provide reliable data COPD prevention management.Methods The residents in five communities Harbin,aged over 40 years old.were recruited voluntarily from September 2009 to March 2011 using questionnaire survey lung function examination.The post-bronchodilator FEV1/FVC＜ 0.70 was defined as COPD.Those individuals with FEV1/FVC lower than 0.7 would received history inquiry,X-ray chest ECG...