A5100399138- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Osteoarthritis Treatment and Mechanisms
- Traditional Chinese Medicine Analysis
- MicroRNA in disease regulation
- Inflammatory mediators and NSAID effects
- Immune Cell Function and Interaction
- Inflammasome and immune disorders
- Healthcare and Venom Research
- Gut microbiota and health
- Reproductive System and Pregnancy
- RNA Research and Splicing
- Traditional Chinese Medicine Studies
- Systemic Sclerosis and Related Diseases
- Mathematical Biology Tumor Growth
- Cancer, Lipids, and Metabolism
- IL-33, ST2, and ILC Pathways
- RNA and protein synthesis mechanisms
- Immune Response and Inflammation
- Genetics and Neurodevelopmental Disorders
- Pluripotent Stem Cells Research
- Endometrial and Cervical Cancer Treatments
- Connective Tissue Growth Factor Research
- Bone Metabolism and Diseases
Zhejiang Chinese Medical University
2022-2025
Ningbo No.6 Hospital
2025
Huazhong University of Science and Technology
2022-2024
Foshan Maternity and Child Health Care Hospital
2023-2024
Zhuzhou Central Hospital
2023-2024
Central South University
2023-2024
Zhongda Hospital Southeast University
2023-2024
Southern Medical University
2023
Nanjing University
2023
Nanjing General Hospital of Nanjing Military Command
2023
Lung cancer is the leading cause of cancer‑associated mortality worldwide. The aim present study was to identify differentially expressed genes (DEGs) and enriched pathways in lung by bioinformatics analysis, provide potential targets for diagnosis treatment. Valid microarray data 31 pairs tissues matched normal samples (GSE19804) were obtained from Gene Expression Omnibus database. Significance analysis gene expression profile used DEGs between tissues, a total 1,970 DEGs, which...
Macrophages belong to a special phagocytic subgroup of human leukocytes and are one the important cells immune system. Small noncoding RNAs group small RNA molecules that can be transcribed without ability encode proteins but could play specific function in cells. SncRNAs mainly include microRNAs (miRNAs) piwi-interacting (piRNAs), nucleolar (snoRNAs), nuclear (snRNAs) repeat RNAs. We used high-throughput sequencing analysis qPCR detect expression changes RNAome during macrophage...
Allopolyploid oilseed rape (Brassica napus) is an important oil crop and vegetable. However, the latest version of its reference genome, with collapsed duplications, gaps, other issues, prevents comprehensive genomic analysis. Herein, we report a gap-free assembly rapeseed cv. Xiang5A genome using combination ONT (Oxford Nanopore Technologies) ultra-long reads, PacBio high-fidelity Hi-C datasets. It includes assemblies all 19 chromosomes telomere-to-telomere eight chromosomes. Compared...
To investigate whether autophagy mediates 2-methoxyestradiol (2-ME)-inhibited hypoxia-induced fibrosis and endothelial-to-mesenchymal transition (endoMT) in SSc.Autophagy the skin of SSc patients was assessed by transmission electron microscopy. fibroblasts human umbilical vein endothelial cells (HUVECs) were cultured under hypoxic (1% O2) conditions with 2-ME or inhibitor. Collagen I connective tissue growth factor (CTGF) vascular (VE)-cadherin, CD31, vimentin α-smooth muscle actin (α-SMA)...
Osteoarthritis (OA) is one of the most common chronic musculoskeletal disorder worldwide, representing a major source disability, pain and socioeconomic burden. Yet effective pharmaceutical treatments applied in clinical works are merely symptomatic management with uncertainty around their long-term safety efficacy, namely no drugs currently capable modulating biological progression OA. Here, we identified potent anti-inflammatory as well anti-oxidative properties Nitidine Chloride (NitC),...
To investigate the mechanism of 2-methoxyestradiol (2-ME) in inhibiting hypoxia-induced collagen synthesis fibroblasts SSc.The expressions hypoxia-inducible factor 1 alpha (HIF-1α) and connective tissue growth (CTGF) skin specimens derived from SSc patients healthy volunteers were examined by immunohistochemistry. HIF-1α was knocked down lentiviral transduction, dermal cultured under normoxic (21% O2) or hypoxic (1% condition treated with PI3K inhibitor LY294002, rapamycin 2-ME (25 μM). The...
Previous observational studies have observed a correlation between sedentary behavior and osteoporosis. However, conclusions from these been contradictory. To explore the potential causal relationship osteoporosis, we conducted Mendelian randomization analysis. A two-sample was adopted to of leisure with We employed 5 methods estimate associations Univariable results provided evidence for time spent on computer-use bone mineral density estimated by heel quantitative ultrasound (eBMD)...
Hepatocarcinogenesis is a highly complicated process that promoted by series of oncogenes. Our study aims to identify novel oncogenes promoting hepatocellular carcinoma (HCC) bioinformatic analysis and experimental validation. Here, we reported S100 calcium binding protein A10 (S100A10) was screened out as potential oncogene in HCC integrated OEP000321 dataset the Cancer Genome Atlas (TCGA)-Liver-Cancer data. Furthermore, S100A10 expressed samples observably associated with patients’ overall...
Objective To explore the causal association between breakfast skipping and bone mineral density (BMD) through two-sample Mendelian randomisation (MR) analysis. Methods A MR approach was adopted to relationship of with BMDs (across three skeletal sites five age groups). Publicly available genome-wide study summary data were used for We methods estimate associations BMDs: inverse-variance weighting (IVW), MR-Egger, weighted median, simple mode, mode. IVW main analysis remaining four as...
// Zhou Xing 1, 4, * , Minling Zeng Huixian Hu 2, Hui Zhang 2 Zhuofang Hao 6 Yuesheng Long 5 Shengqiang Chen Hang Su Zhongmin Yuan Meng Xu 1 Jingqi 3 Department of Oncology, the First Affiliated Hospital, Jinan University, Guangzhou 510632, People's Republic China Translational Medicine Center, Second Hospital Medical 510260, 4 Neurosurgery, Institute Neuroscience; Key Laboratory Neurogenetics and Channelopathies Guangdong Province Ministry Education China, Pathology, These authors have...
Bone marrow mesenchymal stem cells (BMSCs) have been used in cell-based therapy for various diseases due to their self-renewing ability and differentiation potential types of immunoprivileged properties. However, the proliferation capability functionality BMSCs are known decline with aging, which severely limits extensive applications BMSC-based therapies. To date, exact mechanism involved cellular senescence remains unclear. RNA is thought be initial molecular form life on earth. It also...
Abstract Background High mobility group box-1 (HMGB1) is an endogenous danger signal that mediates activation of the innate immune response including NLR pyrin domain containing 3 (NLRP3) inflammasome and proinflammatory cytokine release. Although HMGB1 NLRP3 have been implicated in pathophysiology seizures, correlation between expression has not determined children with febrile seizures (FS). To explore relationship extra-cellular FS, we analyzed serum HMGB1, NLRP3, caspase-1, cytokines...
Aging | doi:10.18632/aging.205582. Xing Zhou, Wen-Kai Li, Chen Zhuang, Xing-Chen Xue-Fei Zhao, Yu Pan, Wen-Xuan Guo, Yi-Wen Yang, Cen-Zhuo Sheng, Zhe-Fei Xie, Jin-Sheng Yu, Yi-Xuan Chen, Li-Kang Wang, Tian-You Ma, Kang-Xiang Zhu, Ke-Meng Xiang, Ru-Jie Zhuang
Background: Sepsis is a life-threatening clinical syndrome caused by dysregulated host response to infection. The mechanism underlying sepsis-induced immune dysfunction remains poorly understood. Natural killer T (NKT) cells are cytotoxic lymphocytes that bridge the innate and adaptive systems, role of NKT in sepsis not entirely understood, cell cluster differences remain unexplored. Methods: Mendelian randomization (MR) analyses were first conducted investigate causal relationship between...
In this paper, we consider the fully parabolic nu’trient taxis system: ut = d1Δu − ∇ · (ϕ(u, v)∇v), vt d2Δv ξug(v) μv + r(x, t), x ∈ Ω, t > 0 under homogeneous Neumann boundary conditions in a convex bounded domain with smooth boundary. We show that system possesses global classical solution domains of arbitrary dimension and at least one generalized high-dimensional domain. addition, asymptotic behavior solutions is discussed. Our results not only generalize partly improve upon...
Abstract Objective To clarify the role of RNA polymerase III A (POLR3A)/type I IFN in pathogenesis SSc. Methods Cytosolic DNA and stimulator genes (STING) pathway skin or serum SSc patients were detected by immunofluorescence, immunohistochemistry western blotting. from human macrophages was transfected to fibroblasts umbilical vein endothelial cells (HUVECs) then markers POLR3A/STING real-time qPCR, blotting confocal microscopy. After H151 treatment knocking down POLR3A/STING, type...
Gait is influenced by race, age, and diseases type. Reference values for gait are closely related to numerous health outcomes. To gain a comprehensive understanding of patterns, particularly in relation race-related pathologies disorders, it crucial establish reference daily life considering sex age. Therefore, our objective was present age-based life, providing valuable foundation further research clinical applications.To lower extremity joint kinematics kinetics during asymptomatic adult...
TNF-α has long been regarded as a proimmune cytokine involved in antimicrobial type 1 immunity. However, the precise role of immunity remains poorly understood. We found that TNF-α–deficient (TNF–/–) mice quickly succumbed to respiratory failure following lung infection with replication-competent mycobacteria, because apoptosis and necrosis granuloma structure. Tissue destruction was result an uncontrolled immune syndrome characterized by expansion activated CD4 CD8 T cells, increased...