A5022038477- MicroRNA in disease regulation
- Ubiquitin and proteasome pathways
- Circular RNAs in diseases
- Cell death mechanisms and regulation
- CRISPR and Genetic Engineering
- Cancer-related molecular mechanisms research
- interferon and immune responses
- Extracellular vesicles in disease
- Lung Cancer Research Studies
- Peptidase Inhibition and Analysis
- Cancer Research and Treatments
- RNA regulation and disease
- Hippo pathway signaling and YAP/TAZ
- Glycosylation and Glycoproteins Research
- MXene and MAX Phase Materials
- Advanced biosensing and bioanalysis techniques
- Protein Kinase Regulation and GTPase Signaling
- Retinal Development and Disorders
- Nanoplatforms for cancer theranostics
- Cancer-related gene regulation
Shenzhen Second People's Hospital
2021-2024
Soochow University
2016-2023
University of Science and Technology of China
2021-2023
Jiangsu University
2015
Abstract Programmed death ligand-1 (PD-L1) is expressed on the surface of tumor cells and binds to programmed cell protein-1 (PD1) T cells, leading cancer immune evasion via inhibition T-cell function. One characteristics small lung (SCLC) its ineffective anti-tumor response highly immunosuppressive status in microenvironment. SCLC have been shown generate extracellular vesicles (EVs), which may play an important role progression. We thus hypothesized that EVs be mediators immunosuppression...
PDZ binding-kinase (PBK) (also named T-lymphokine-activated killer cell-originated protein kinase (TOPK)), a serine/threonine kinase, is tightly controlled in normal tissues but elevated many tumors, and functions tumorigenesis metastasis. However, the signaling that regulates expression of PBK cancer cells remains elusive. Here we show atorvastatin (Lipitor), an inhibitor hydroxymethylglutaryl co-enzyme A (HMG-CoA) reductase rate-limiting enzyme mevalonate pathway, down-regulates by...
Resistance to first-line chemotherapy drugs has become an obstacle improving the clinical prognosis of patients with small cell lung cancer (SCLC). Exosomal microRNAs have been shown play pro- and anti-chemoresistant roles in various cancers, but their role SCLC chemoresistance never explored. In this study, we observed that expression exosomal miR-92b-3p was significantly increased who developed chemoresistance. Luciferase reporter analysis confirmed PTEN a target gene miR-92b-3p. The...
Introduction: Small cell lung cancer (SCLC) is a subtype of with high malignancy and poor prognosis. Rapid acquisition chemoresistance one the main reasons leading to clinical treatment failure SCLC. Studies have indicated that circRNAs participate in multiple processes tumor progression, including chemoresistance. However, molecular mechanisms driving SCLC are not well specified. Methods: The differentially expressed were screened by transcriptome sequencing chemoresistant chemosensitive...
Mixed lineage kinase domain‐like protein (MLKL) is the terminal effector of necroptosis, a form regulated necrosis. Optimal activation which eliminates infected cells, critical for antiviral host defense. MicroRNAs (miRNAs) regulate expression genes involved in various biological and pathological processes. However, roles miRNAs necroptosis‐associated defense remain largely unknown. We screened library identified miR‐324‐5p as most effective suppressor necroptosis. MiR‐324‐5p downregulates...
Abstract In the realms of bioengineering and biopharmaceuticals, there exists a critical demand for advanced genetic tools that can interact with specific cell signaling pathways to accurately identify target various types. This research introduces innovative CRISPR‐ADAReader system, which enables precise manipulation activity through sensing RNA. Featuring both positive negative feedback loops, system allows tailored regulation across different types in response internal signals, showcasing...
Abstract Background: Gastric cardia adenocarcinoma (GCA) is the most aggressive subtype of gastric carcinoma. New molecular markers and therapeutic targets are needed for diagnosis, prognosis treatment GCA. This study to establish E3 ubiquitin ligase Nedd4-1 as a prognostic biomarker predict survival guide GCA patients. Methods: Expression in 214 tumor samples was detected by immunohistochemistry staining (IHC) using tissue microarray assay (TMA). Association with cumulative TNM stages I-III...
Abstract Evasion of cell death is a hallmark cancer cells. Receptor-interacting protein kinase 1 (RIPK1) common mediator in signaling pathways apoptosis and necroptosis. MicroRNAs (miRNAs) are non-coding small RNAs that involved various biological processes such as proliferation by regulating target genes. Here, we identified miR-148a miR-152 suppressors TNF-induced based on the screening apoptosis-regulating miRNAs. Elevated expression or blocks cellular activation caspase-8 caspase-3...