A5040852129- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Retinal Diseases and Treatments
- Ocular Surface and Contact Lens
- interferon and immune responses
- Connexins and lens biology
- Ophthalmology and Eye Disorders
- Biochemical effects in animals
- Retinal Imaging and Analysis
- Intraocular Surgery and Lenses
- Proteoglycans and glycosaminoglycans research
- Vascular Malformations and Hemangiomas
- Artificial Intelligence in Healthcare and Education
- Corneal Surgery and Treatments
- Ocular Infections and Treatments
- Acupuncture Treatment Research Studies
- Neurological Disease Mechanisms and Treatments
- Peptidase Inhibition and Analysis
- Cancer-related molecular mechanisms research
- TGF-β signaling in diseases
- Pluripotent Stem Cells Research
- S100 Proteins and Annexins
- Bioactive natural compounds
- Plant-based Medicinal Research
- Retinal Development and Disorders
Central South University
2013-2025
Jinan University
2023-2025
He Eye Hospital
2022-2025
Second Xiangya Hospital of Central South University
2017-2021
Third Xiangya Hospital
2021
Yueyang Second People's Hospital
2016
Xiangya Hospital Central South University
2013
Abstract Noncoding RNAs (ncRNAs), including long ncRNAs (lncRNA) have manifested an important role in the pathophysiology of many diseases. Glaucoma is a primary cause irreversible blindness worldwide. However, involvement lncRNAs glaucoma remains largely unknown. Here, we performed lncRNA expression assay based on clinical tissues and identified specific functional lncRNA, NR_003923, investigated its potential glaucoma. Knockdown NR_003923 human Tenon’s capsule fibroblast cells (HTFs)...
Age-related eye diseases (AREDs) have become increasingly prevalent with the aging population, serving as leading causes of visual impairment worldwide. Epigenetic clocks are generated based on DNA methylation (DNAm) levels and considered one most promising predictors biological age. This study aimed to investigate bidirectional causal association between epigenetic common AREDs or glaucoma endophenotypes. Instrumental variables for clocks, AREDs, endophenotypes were obtained from...
<title>Abstract</title> <bold>Background</bold> Recent studies have found that ferroptosis may be involved in the process of trabecular meshwork injury glaucoma. This study aims to reveal ferroptosis-related gene signature primary open-angle glaucoma (POAG) and identify small molecule drugs as new direction therapy. <bold>Methods</bold> Ferroptosis-related indicators POAG patients chronic ocular hypertension (COH) rats were detected by ELISA kits. The dataset (GSE27276) from GEO database...
Aims This research aims to establish a chromatin regulator (CR) signature provide new epigenetic insights into the pathogenesis of primary open-angle glaucoma (POAG).
The purpose of this study was to interrogate the potential role N6-methyladenosine (m6A) regulators in process trabecular meshwork (TM) tissue damage patients with primary open-angle glaucoma (POAG). Firstly, expression profile m6A TM tissues POAG comprehensively analyzed by bioinformatics analysis; Plasmid transfection and siRNA gene interference were used enhance or weaken levels YTHDC2 human cells (HTMCs); Cell migration ability detected transwell chamber assay; Immunofluorescence...
To investigate the accuracy of intraocular pressure (IOP) as measured by a Reichert Ocular Response Analyzer (ORA), well relationship between central corneal thickness (CCT) and IOP ORA, Goldmann applanation tonometry (GAT), dynamic contour (DCT).A total 158 healthy individuals (296 eyes) were chosen randomly for measurement IOP. After CCT was using A-ultrasound (A-US), GAT, DCT devices in randomized order. The values acquired each three tonometries compared, analyzed separately. Two values,...
To explore the features of dominant and nondominant eyes in patients with cataracts predict ocular dominance shift (ODS) based on preoperative indicators.
A 59-year-old man presented with a slowly enlarging mass in the lateral orbital rim of left eye for 1 year. He also reported history crania defect front bone (6 years earlier) which was confirmed on former computed tomographic (CT) scan. On examination, solid lesion located frontal extends to eye. CT scan showed poorly defined margins, invaded neighboring tissue and nearly damaged bone, exact site preceding defect. Complete resection performed, clinical diagnosis cavernous hemangioma...
Singleton-Merten syndrome (SMS) is a rare immunogenetic disorder affecting multiple systems, characterized by dental dysplasia, aortic calcification, glaucoma, skeletal abnormalities, and psoriasis. Glaucoma, key feature of both classical atypical SMS, remains poorly understood in terms its molecular mechanism caused DDX58 mutation. This study presented novel variant (c.1649A>C [p.Asp550Ala]) family with childhood glaucoma. Functional analysis showed that an increase IFN-stimulated gene...
Although it is now understood that most antiglaucoma surgeries fail because of scarring the filtering tract, underlying mechanism remains to be elucidated. The present study investigated by which interleukin (IL)-22/IL-22 receptor alpha 1 (IL-22RA1) signaling pathway regulates scar formation in glaucoma patients.
Abstract Glaucoma and Alzheimer’s disease are critical degenerative neuropathies with global impact. Previous studies have indicated that glaucomatous damage could extend beyond ocular structures, leading to brain alterations potentially associated risk. This study aimed explore the causal associations among glaucoma, alterations, disease. We conducted a comprehensive investigation into genetic correlation causality between glaucoma endophenotypes, cerebral cortical surficial area thickness,...
To evaluate the agreement between intraocular pressure (IOP) readings measured by Ocular Response Analyzer (ORA) and corrected Goldmann applanation tonometry (cGAT), derived from "gold standard" for clinical measurement of IOP, in eyes subjects who have undergone laser situ keratomileusis (LASIK). The effects corneal biomechanical properties on IOP were also evaluated.This was a retrospective cross-sectional study. 148 patients LASIK ORA GAT one after another. cGAT calculated according to...
The aim of the present study was to compare ocular pulse amplitude (OPA) in patients with different types glaucoma using dynamic contour tonometry (DCT), evaluate and systemic factors associated OPA verify whether measured by DCT is an independent predictor for diagnosis. A total 217 eyes participants following five groups were included this cross‑sectional study: Chronic angle closure (CACG), primary open glaucoma, normal tension (NTG), suspected (SOAG) control (NC). tests simultaneously...
Poor adherence to treatment is a problem in glaucoma, and patient dissatisfaction with topical glaucoma medication barrier adherence. The objective of this study was evaluate patients' satisfaction fixed-combination bimatoprost/timolol ophthalmic solution (BTFC).This observational, multicenter conducted China adults treated BTFC for 1-3 months. Five hundred patients answered questionnaire concerning their demographic characteristics, history treatment, use BTFC. primary endpoint assessed on...