It is of great importance in telemedicine to protect authenticity and integrity medical images. They are mainly addressed by two technologies, which region interest (ROI) lossless watermarking reversible watermarking. However, the former causes biases on diagnosis distorting none (RONI) introduces security risks segmenting image spatially for watermark embedding. The latter fails provide reliable recovery function tampered areas when protecting integrity. To address these issues, a novel...

Diabetes is a widespread disease in the world and can lead to diabetic retinopathy, macular edema, other obvious microvascular complications retina of human eye. This study attempts detect retinopathy (DR), which has been main reason behind blindness people last decade. Timely or early treatment necessary prevent some DR control blood glucose. very difficult time-consuming manual diagnosis because its diversity complexity. work utilizes deep learning application, convolutional neural network...

To investigate the posterior choroidal thickness in healthy subjects of three different ethnicities.In this prospective cross-sectional study, 88 individuals (176 eyes) was measured using enhanced depth imaging-spectral domain optical coherence tomography. Subfoveal between retinal pigment epithelium-Bruch membrane complex and chorioscleral interface. Nasal, temporal, superior, inferior thicknesses at 0.5, 1.5, 3.0 mm locations from fovea were evaluated as well.Males females perfectly...

Graves' orbitopathy (GO), the common extrathyroidal complication of disease (GD), is characterized by orbital fibroblast stimulation, adipogenesis, and hyaluronan production. Recently, gut microbiota its metabolites have garnered attention for their possible involvement in GO. This study utilized an animal model GO examined effects butyrate treatment on cells microbiota. Ex vivo experiments were performed using fibroblasts derived from healthy patients' with tissue to evaluate vitality,...

To investigate the accuracy of intraocular pressure (IOP) as measured by a Reichert Ocular Response Analyzer (ORA), well relationship between central corneal thickness (CCT) and IOP ORA, Goldmann applanation tonometry (GAT), dynamic contour (DCT).A total 158 healthy individuals (296 eyes) were chosen randomly for measurement IOP. After CCT was using A-ultrasound (A-US), GAT, DCT devices in randomized order. The values acquired each three tonometries compared, analyzed separately. Two values,...

Purpose Transdifferentiation of human Tenon fibroblasts to myofibroblasts and subsequent deposition extracellular matrix is a key step in the scarring after glaucoma filtration surgery. The p38 signaling pathway plays an important role cell proliferation differentiation, its upstream regulators downstream molecules are widely distributed eye. We aimed investigate activation that anti-fibrotic mechanism rosiglitazone modulation pathway. Methods Cultured were stimulated with transforming...

Purpose . To determine the correlations between peripapillary vessel density, retinal nerve fibre layer (RNFL) thickness, and myopic indices at retina quadrants with optical coherence tomography angiography (OCTA) in Chinese. Methods Fifty-six subjects a mean spherical equivalent (MSE) of −3.63 ± 0.29 D were included. Peripapillary RNFL thickness density four sectors (superior, nasal, inferior, temporal quadrants) determined by OCTA, main outcomes analyzed. Results Negative found axial...

In recent years, the broad application of optical coherence tomography and vitrectomy, combined with research efforts in maculopathy high myopia have provided many achievements, such as new classification myopic traction (MTM). Here, we review latest developments diagnosis treatment MTM, including its conception, clinical characteristics, pathogenesis, stages, options for surgical treatment.

A macular hole is a rare complication after high-voltage electrical shock injury and only few cases have been reported to date. To the best of our knowledge, this first report bilateral impending holes shock. We case in 39-year-old male Chinese patient who sustained three months prior presentation. Our complained gradually diminished eyesight both eyes, with visual acuity 20/100 20/40 his right left eyes respectively. underwent pars plana vitrectomy accompanied by octafluoropropane gas...

Purpose: To investigate the changes in macular microvascular structure after anti-vascular endothelial growth factor (anti-VEGF) treatment retinal vein occlusion (RVO) patients with and without ischemia. Methods: A total of 39 were divided into ischemia group (n = 22) nonischemia 17) at baseline. All received an intravitreal injection ranibizumab a 3+ pro re nata (PRN) regimen. The foveal avascular zone (FAZ) areas, vessel density (VD), ischemic index (ISI) evaluated baseline 3 6 months...

Axenfeld-Rieger syndrome (ARS) is an autosomal dominant genetic disorder that characterized by specific abnormalities of the anterior segment eye. Heterozygous mutations in two developmental transcription factor genes PITX2 and FOXC1 have been identified within ARS patients, accounting for 40 to 70% cases. Our purpose describe clinical findings a Chinese family with ARS. An three affected members was recruited. The patients underwent series complete ophthalmologic examinations, general...

Bruch's membrane opening (BMO) is an important biomarker in the progression of glaucoma. minimum rim width (BMO-MRW), cup-to-disc ratio spectral domain optical coherence tomography (SD-OCT) and lamina cribrosa depth based on BMO are measurable parameters for glaucoma diagnosis. The accuracy measuring these significantly affected by detection. In this paper, we propose a method automatically detecting SD-OCT volumes accurately to reduce impact border tissue vessel shadows. includes three...

Combined branch retinal artery and central vein occlusion is a rare condition that has been infrequently reported. This case report, aside from reporting the above-mentioned condition, highlights importance of performing spectral domain optical coherence tomography in establishing complete diagnosis, especially uncertain complicated cases. We also present findings combined unilateral simultaneous occlusion. single an initially missed, with 51-year-old female Chinese patient without...

Structure analysis of the optic-nerve head (ONH) and retinal image registration are important for diagnosing eye diseases. Thus, a 3D reconstruction method proposed in this paper. The former exploits disparity map estimation as depth cue to disambiguate relative positions then uses guided filter obtain final map. Using map, red-cyan anaglyph can be computed structure ONH reconstructed. latter establishes vasculature relationship between images mosaic used feature extraction matching, divides...

Abstract Background Glaucoma is an irreversible eye disease caused by the optic nerve injury. Therefore, it usually changes structure of head (ONH). Clinically, ONH assessment based on fundus image one most useful way for glaucoma detection. However, effective representation a challenging task because its structural result in complex and mixed visual patterns. Method We proposed novel feature Radon Wavelet transform to capture these Firstly, (RT) used map into domain, which spatial radial...

The foveal avascular zone (FAZ) is a biomarker for quantifying diabetic macular ischemia (DMI), to automate the identification and quantification of FAZ in DMI, using an improved U-Net convolutional neural network (CNN) establish CNN model based on optical coherence tomography angiography (OCTA) images same purpose. boundaries full-thickness retina 6 × mm en face OCTA DMI normal eyes were manually marked. Seventy percent used as training set, ten these validation set train with two attention...

AIM: To report a novel mutation in FBN1 gene Chinese consanguineous family with common Marfan syndrome (MFS) phenotype and an unusual bilateral macular degeneration. METHODS: Ophthalmic, cardiovascular systemic examinations were performed, genomic DNA extracted from all living members. The 24-32 exon mutations of screened by Sanger Sequencing members 100 unrelated healthy individuals. RESULTS: In the four-generation family, classic MFS phenotypes observed 5 patients, 2 them had peculiar...

To evaluate the repeatability of central corneal thickness (CCT) measurement by entacam, and agreement CCT measured Pentacam ultrasound pachymetry (USP) in Chinese myopia. Thereby investigate possibility as a substitute for USP before refractive surgery. The effects curvature on were also evaluated.One hundred forty-eight right eyes 148 individual with myopia included this study. Three successive measurements followed 10 carried out eyes. Mean taken each device was calculated comparison....

Objective To observe the therapeutic effect of pars plana vitrectomy (PPV) on myopic traction maculopathy (MTM). Methods The clinical data 31 eyes 29 patients with MTM diagnosed by time domain optical coherence tomography (TD-OCT) and slit-lamp ophthalmoscopy were retrospectively analyzed. cases divided into 2 groups according to stage MTM: 12 10 at early in group 1 ; 19 most Advanced 2. All these had undergone PPV 10%-15% inert gas filling. followed post-operatively for 6 months average 8...