A5056964905- Nerve injury and regeneration
- Glaucoma and retinal disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Cholinesterase and Neurodegenerative Diseases
- Flavonoids in Medical Research
- Retinal Development and Disorders
- Evolution and Paleontology Studies
- Paleontology and Evolutionary Biology
- Neuroscience and Neuropharmacology Research
- Ubiquitin and proteasome pathways
- Neuropeptides and Animal Physiology
- Plant biochemistry and biosynthesis
- Medicinal Plants and Neuroprotection
- Atherosclerosis and Cardiovascular Diseases
- Ophthalmology and Eye Disorders
- Natural product bioactivities and synthesis
- Antiplatelet Therapy and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Phytochemistry and Biological Activities
- Calpain Protease Function and Regulation
- Microtubule and mitosis dynamics
- Cancer Cells and Metastasis
- Nicotinic Acetylcholine Receptors Study
- Mechanisms of cancer metastasis
First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
2016-2025
Hunan University of Traditional Chinese Medicine
2016-2025
Changzhi Medical College
2024
Guangdong University of Technology
2024
Hunan International Economics University
2024
Hunan University
2014-2024
Geological Museum of China
2024
Hunan Normal University
2016-2021
Tianjin Medical University
2009-2021
Tianjin First Center Hospital
2015-2021
Large quadrupedal sauropod dinosaurs of the group Titanosauria were globally distributed in Late Cretaceous. Many titanosaurian species have been discovered eastern Asia, but most them are controversial and represented by poorly preserved remains. Here, we describe a new titanosaur, Gandititan cavocaudatus gen. et sp. nov., based on partial skeleton recovered from lower Upper Cretaceous Ganxian County, Ganzhou City, southern China, comprising six articulated cervical vertebrae, two dorsal...
Abstract The proteolytic cleavage of the amyloid precursor protein (APP) has been shown to be modulated through specific muscarinic receptor activation in vitro both transfected cell lines and native brain slices, whereas a demonstration receptor‐mediated control APP processing under vivo conditions is still lacking. To simulate alterations stimulation , we have (i) specifically reduced cortical cholinergic innervation rats using partial immunolesions with 192lgG–saporin, (ii) restored...
We investigated the efficacy of miR-29b in inhibiting scar formation rabbits who undergo glaucoma filtering surgery (GFS).Trabeculectomy was performed on 60 diagnosed with glaucoma. The were divided into 5 groups: a blank group, single positive control group that treated intraoperative mitomycin C (MMC), negative twice empty vector postoperatively, and experimental Lentivirus-mediated after being subjected to trabeculectomy. operated eyes tracked followed up from postoperative days 1 28...
<title>Abstract</title> <bold>Background</bold> Synaptic abnormalities are hallmark pathological features of autism spectrum disorders (ASD), contributing to the behavioral impairments frequently observed in these neurodevelopmental conditions. Microglia, as brain’s primary immune cells, essential for synaptic refinement during adolescent development. Disrupted microglial-mediated pruning has been implicated pathophysiology ASDs, however, underlying mechanisms remain incompletely elucidated....
Nerve growth factor (NGF) provides critical trophic support to the cholinergic basal forebrain neurons that express high levels of low-affinity NGF receptor (p75NGFR) in adult rat brain. Intraventricular injection 192 IgG-saporin, made by coupling monoclonal antibody p75NGFR IgG cytotoxin saporin, selectively destroys p75NGFR-bearing and was used here examine effects selective lesions on brain protein levels. We showed IgG-saporin produced significant long-lasting elevation hippocampus,...
The aim of the present study was to examine effects nerve growth factor on brain cholinergic function after a partial immunolesion rat basal forebrain neurons (CBFNs) by 192 IgG-saporin. Two weeks intraventricular injections 1.3 μg IgG-saporin, about 50% CBFNs were lost which associated with 40–60% reductions choline acetyltransferase (ChAT) and high-affinity uptake (HACU) activities throughout system. groups lesioned animals received transplantations mouse 3T3 fibroblasts retrovirally...
The cholinergic neurons of the basal forebrain (CNBF) are major source innervation cortex and hippocampus. In Alzheimer's disease aged brain, there severe losses in nucleus basalis Meynert, leading to a reduction cortical activity which correlates with severity cognitive deficits. While is evidence that central nervous system (CNS) displays impaired stress response signaling, pharmacologic treatments neurotrophic factors appear ameliorate these age-associated To mimic deficits experimental...
Abstract: It is well documented that nerve growth factor (NGF) plays an important role in maintaining functions of cholinergic basal forebrain neurons. In the present study, we tested hypothesis activity controls NGF levels cholinoceptive neurons cerebral cortex and hippocampus. To address question, used both deafferentation hippocampus by immunolesion with 192IgG‐saporin chronic pharmacological treatment sham‐treated immunolesioned rats agonist pilocarpine antagonist scopolamine. We...
In the present study, we compare effects of cholinergic deafferentation hippocampus, cortex, and olfactory bulb young aged rats on nerve growth factor (NGF) protein levels in these areas. We also describe glial responses to intraventricular injections immunotoxin, 192 IgG-saporin aged. Choline acetyltransferase (ChAT) activity was dramatically decreased basal forebrain target areas neurons (CBFNs) immunolesioned a lesser extent their counterparts. After total immunolesion, NGF significantly...
A 59-year-old man presented with a slowly enlarging mass in the lateral orbital rim of left eye for 1 year. He also reported history crania defect front bone (6 years earlier) which was confirmed on former computed tomographic (CT) scan. On examination, solid lesion located frontal extends to eye. CT scan showed poorly defined margins, invaded neighboring tissue and nearly damaged bone, exact site preceding defect. Complete resection performed, clinical diagnosis cavernous hemangioma...
Two new lupene-type triterpenoids, 3β,6β-dihydroxylup-20(29)-en-28-oic acid β-glucopyranosyl ester (1) and 2α-acetoxyl-3β,6β-dihydroxylup-20(29)-en-28-oic (2), along with 18 known compounds, were isolated from Liquidambar formosana. The structures elucidated on the basis of spectroscopic methods, including UV, IR, ESIMS, 1D- 2D-NMR experiments, as well by comparison spectral data those related compounds.
This study integrates life cycle assessment (LCA) and system dynamics (SD) modeling to evaluate the potential of Artificial Intelligence (AI)-enhanced anaerobic ammonium oxidation (anammox) technology in industrial wastewater treatment. The research examines environmental, economic, social benefits AI optimization, with a focus on its long-term implications for sustainable development. By constructing detailed LCA model, analyzes environmental impacts treatment across lifecycle, from raw...
The Upper Cretaceous Ganzhou Basin of Jiangxi Province, South China is among one the richest egg fossil sites in world and yields abundant exquisite clutches embryonic eggs, especially oviraptorosaurs. Hadrosaurian, troodontid, potential dromaeosaurid fossils were also reported, though they rare. All these reported eggs vary morphology but have relatively large sizes. Here, we report a partial clutch with six complete small from Tangbian Formation City, Southeast China. microstructure...
Objective: Acute acquired concomitant esotropia (AACE) is a distinct subtype of esotropia. The purpose this retrospective study was to describe the clinical characteristics and discuss diagnostic therapeutic management, evaluate effect prism treatment.Methods: records 30 patients who presented with acute-onset diplopia at General Hospital Central Theater Command from August 2015 November 2018 were reviewed. All underwent complete medical history, ophthalmological orthoptic examinations,...
Abstract Membrane ruffling plays an important role in the directed cell migration and escape of tumor cells from monolayer. Metastasis suppressor 1 (MTSS1), also known as missing metastasis, has been implicated morphology, motility, development. Here, dynamic interaction proteins associated with MTSS1 involved membrane were determined by cross‐linking mass spectrometry analysis. We identified α‐actinin 4 (ACTN4) interacting protein confirmed a direct between ACTN4. Moreover, co‐expression...