A5071870182- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Corneal surgery and disorders
- Ophthalmology and Eye Disorders
- Intraocular Surgery and Lenses
- Ocular Surface and Contact Lens
- Cancer, Hypoxia, and Metabolism
- Retinal Development and Disorders
- Retinal and Optic Conditions
- Corneal Surgery and Treatments
- Retinal Imaging and Analysis
- Ocular Oncology and Treatments
- Ophthalmology and Visual Impairment Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Cerebral Venous Sinus Thrombosis
- Traumatic Ocular and Foreign Body Injuries
- Retinopathy of Prematurity Studies
- Proteoglycans and glycosaminoglycans research
- S100 Proteins and Annexins
- Mitochondrial Function and Pathology
- Gut microbiota and health
- Connexins and lens biology
- Adenosine and Purinergic Signaling
- Dental Health and Care Utilization
- Retinal and Macular Surgery
Sun Yat-sen University
2016-2025
Southern Medical University
2023-2024
Nanfang Hospital
2023-2024
Sinolight (China)
2024
State Key Laboratory of Ophthalmology
2020-2024
Key Laboratory of Guangdong Province
2022-2024
Hainan Eye Hospital
2022
Sixth Affiliated Hospital of Sun Yat-sen University
2022
Zhongshan Ophthalmic Center, Sun Yat-sen University
2011-2021
National Natural Science Foundation of China
2018
Retinal vascular leakage, inflammation, and neovascularization (NV) are features of diabetic retinopathy (DR). Fenofibrate, a peroxisome proliferator-activated receptor α (PPARα) agonist, has shown robust protective effects against DR in type 2 patients, but its on 1 diabetes have not been reported. This study evaluated the efficacy fenofibrate models determined if effect is PPARα dependent. Oral administration significantly ameliorated retinal leakage leukostasis streptozotocin-induced rats...
To analyze the treatment modalities and trends for neovascular glaucoma (NVG) over past 10 years, we conducted a retrospective analysis at Zhongshan Ophthalmic Center on 1331 NVG inpatients who received 1459 treatments 1383 eyes between January 1, 2012, December 31, 2021. Over time, observed progressive annual increase in both number of patients volume surgeries NVG, with an percentage change (APC) 10.23% (95% confidence interval [CI]: 5.5-15.2%, P = 0.001) 11.59% CI: 6.6-16.9%, 0.001),...
Hypoxia-inducible factor (HIF)-1 is a key oxygen sensor and believed to play an important role in neovascularization (NV). The purpose of this study determine the retinal pigment epithelium (RPE)-derived HIF-1α on ocular NV.Conditional knockout (KO) mice were generated by crossing transgenic expressing Cre RPE with floxed mice, confirmed immunohistochemistry, Western blot analysis, fundus fluorescein angiography. used for oxygen-induced retinopathy (OIR) laser-induced choroidal (CNV)...
Choroidal neovascularization (CNV) is a severe complication of AMD. The Wnt signaling pathway has been shown to mediate angiogenesis. purpose this study was investigate the pathogenic role in CNV and explore therapeutic potential novel inhibitor CNV.Adult rats mice were photocoagulated using diode laser induce CNV. On same day, animals intravitreally injected with monoclonal antibody (Mab2F1) blocking LRP6 or nonspecific mouse IgG. activation target gene expression eyecup determined by...
Abstract This study evaluated illness uncertainty, anxiety and depression among glaucoma patients cataract in China. 263 with primary 100 age-related were recruited sequentially from Zhongshan Ophthalmic Center between October 2013 March 2016. All the participants completed questionnaires for socio-demographic information, Mishel Uncertainty Illness Scale (MUIS) Hospital Anxiety Depression (HADS). 25 of 21 the100 finished two copies same before after surgery. Statistics analyzed using...
Introduction: To investigate the effect of different levels early intraocular pressure (IOP) on long-term outcomes patients with primary open-angle glaucoma (POAG) who were treated trabeculectomy. Methods: This was a retrospective cohort study, total 74 (90 eyes) trabeculectomy surgery at single center from 2021 to 2022. Based IOP 1 day after surgery, they divided into high group (≥ 15mmHg) and low (< 15mmHg). The Student’s t-test chi-square test used compare differences between two...
Abstract Purpose The aim of this study was to describe the genetic and clinical characteristics Chinese patients with autosomal recessive bestrophinopathy ( ARB ). Methods This presents a retrospective observational case series. Twenty‐one 25 clinically healthy family members were recruited. coding regions adjacent intronic BEST 1 analysed via Sanger sequencing. Clinical examinations, including ultrasound biomicroscopy, A‐scan, optical coherence tomography, fundus autofluorescence,...
Few studies have investigated the epidemiology of secondary glaucoma (SG) in China. This study analyzed current profile admitted patients with SG at largest ophthalmic center China.SG cases were retrieved retrospectively by International Classification Disease-10 clinical coding data from January 2010 to December 2019. Demographic data, etiologies, and management analyzed. The ratios etiologies compared previously reported other regions. between 2014 group 2015 2019 compared.A total 11,730...
Retinal ischemia-reperfusion (RIR) is a common pathological condition that can lead to retinal ganglion cell (RGC) death and visual impairment. However, the pathogenesis of RGC loss impairment caused by ischemia remains unclear.A mouse model elevated intraocular pressure (IOP)-induced RIR injury was used. Flash evoked potentials (FVEPs) electroretinography (ERG) recordings were performed assess function. The structural integrity retina number assessed using hematoxylin eosin (HE) staining...
Abstract Background Glaucoma is the most common cause of irreversible blindness, and gut microbiota (GM) associated with glaucoma. Whether this association represents a causal role remains unknown. This study aims to assess potential link between GM various forms glaucoma, emphasising need for cautious interpretation strength these associations. Methods Employing two‐sample bidirectional Mendelian randomisation (MR) framework false discovery rate correction sensitivity analyses, supplemented...
Background . Retinitis pigmentosa (RP) comprises a group of inherited disorders in which patients typically lose night vision adolescence and then peripheral young adulthood before eventually losing central later life. A retrospective case-control study was performed to evaluate differences ocular biometric parameters primary angle-closure glaucoma (PACG) with without concomitant RP determine whether relationship exists between PACG RP. Methods We used ultrasound biomicroscopy (UBM) measure...
Purpose. To investigate macular pigment optical density (MPOD) and its relationship with retinal thickness in primary open angle glaucoma (POAG) patients using the one-wavelength reflectometry method. Methods. A total of 30 eyes from POAG (18 males 12 females, mean age 47.27 ± 16.93) 52 controls (27 25 49.54 19.15) were included this prospective, observational, case-control study. MPOD was measured a 7-degree area Two parameters, max (OD), used for analyses. Spectral-domain-optical coherence...
Background: The imaging and analysis of the ciliary body (CB) are valuable in many potential clinical applications. This study aims to demonstrate anatomy characteristics CB using radial transverse ultrasound biometric microscopy (UBM) healthy Chinese subjects, explore determining factors. Methods: Fifty-four eyes 30 subjects were evaluated. Clinical data, including age, mass index (BMI), intraocular pressure (IOP), axial length (AL), lens thickness (LT), collected. Radial UBM measurements...
Primary open-angle glaucoma (POAG) and primary angle-closure (PACG) are prevailing eye diseases that can lead to blindness. In order provide a non-invasive diagnostic method for glaucoma, we investigated the feasibility of using drop-coating deposition Raman spectroscopy (DCDRS) discriminate patients from healthy individuals based on tear samples. Tears 27, 19 27 POAG patients, PACG normal individuals, respectively, were collected measurement. For high-dimension data analysis, principal...