A5101857551- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Lipid Membrane Structure and Behavior
- Reproductive Biology and Fertility
- Circular RNAs in diseases
- Protein Interaction Studies and Fluorescence Analysis
- interferon and immune responses
- Molecular Sensors and Ion Detection
- Cholesterol and Lipid Metabolism
- Renal and related cancers
- Cancer Mechanisms and Therapy
- Endometriosis Research and Treatment
- Food Chemistry and Fat Analysis
- Reproductive System and Pregnancy
- Lanthanide and Transition Metal Complexes
- RNA Research and Splicing
- Nanoparticle-Based Drug Delivery
- Chromatography in Natural Products
- Liver Disease Diagnosis and Treatment
- Cell death mechanisms and regulation
- Ubiquitin and proteasome pathways
- Supramolecular Self-Assembly in Materials
- Cancer-related Molecular Pathways
- Electrospun Nanofibers in Biomedical Applications
- Neurofibromatosis and Schwannoma Cases
First Hospital of Jilin University
2023-2024
Jilin University
2023-2024
Hunan University
2019-2024
University of Science and Technology of China
2023
Hunan University of Traditional Chinese Medicine
2021-2022
Yueyang Hospital
2021
Shanghai University of Traditional Chinese Medicine
2021
Guilin Medical University
2020-2021
University of Connecticut
2012-2020
Tianjin University
2018
Evidences have indicated that miR-26a-5p regulates the malignant properties of various tumor cells. However, influences on proliferation, apoptosis and invasion are still vague in cervical cancer (CC) cells.The miRNA microarray real-time quantitative PCR (RT-qPCR) analysis were utilized to detect expression patients with CC. Kaplan-Meier plotter was performed evaluate overall survival (OS) The CCK-8, flow cytometry, transwell wound healing analyses respectively used analyze migration CC...
Introduction: Small cell lung cancer (SCLC) is a subtype of with high malignancy and poor prognosis. Rapid acquisition chemoresistance one the main reasons leading to clinical treatment failure SCLC. Studies have indicated that circRNAs participate in multiple processes tumor progression, including chemoresistance. However, molecular mechanisms driving SCLC are not well specified. Methods: The differentially expressed were screened by transcriptome sequencing chemoresistant chemosensitive...
Tripartite motif-containing 67 (TRIM67), a member of the TRIM protein family, is an E3 ubiquitin ligase.Our previous study revealed relationship between TRIM67 expression and carcinogenesis, showing that linked to p-TNM stage, lymph node metastasis, tumour size, cancer cell differentiation, poor prognosis.Additionally, immunostaining results were associated with clinicopathological features.TRIM67 activated Notch pathway in favourable manner enhance invasion, migration,...
Lnc ATG9B-4 aggravated the progression of liver cancer by up-regulating cyclin-dependent-kinase 5 (CDK5). It could be inferred that indirectly regulates expression CDK5 via lncRNA-mediated negative regulation target genes. Therefore, specific molecular mechanism which malignant characteristics cells still needs further study. The differentially expressed genes were identified mRNA sequencing in transfected with or without ATG9B-4. Liver ATG9B-4, ARNTL, si-CDK5. aryl basic helix-loop-helix...
Abstract Context Gestational diabetes mellitus (GDM) is a pregnancy-complicated disease that poses risk to maternal and infant health. However, the etiology of has been not yet elucidated. Objective To detect genetic susceptibility construct nomogram model with significantly associated polymorphisms key clinical indicators for early prediction GDM. Methods Eleven functional single nucleotide (SNPs) screened by genome-wide association study were genotyped in 554 GDM cases 641 healthy...
We report on studies of lipid transfer rates between different morphology nanoparticles and lipids with length acyl chains. The rate dimyristoylphosphatidylcholine (di-C14, DMPC) in discoidal "bicelles" (0.156 h(-1)) is 2 orders magnitude greater than that DMPC vesicles (ULVs) (1.1 × 10(-3) h(-1)). For both bicellar ULV morphologies, increasing the chain by two carbons [going from di-C14 to di-C16, dipalmitoylphosphatidylcholine (DPPC)] causes decrease more magnitude. Results small angle...
Increasing evidence has indicated that microRNA dysregulation is closely related to the occurrence and development of cancers. Herein, we investigated relationship between miR-144-3p CEP55 expression. We then evaluated association expression proliferation, invasion apoptosis non-small cell lung cancer (NSCLC) cells. Real-time quantitative PCR results revealed was over-expressed whereas under-expressed in NSCLC tissues. CCK-8 assay, wound healing flow cytometry further overexpression...
To investigate the effect and mechanism of resveratrol on biological behavior cervical cancer cells (HeLa cells), apoptosis, migration, invasion HeLa were detected by flow cytometry, wound healing, transwell assays. The expression levels Hedgehog signal pathway proteins (smoothened (SMO), zinc finger transcription factors (Gli1), sonic hedgehog homolog (Shh)) quantitative real-time PCR (qPCR) western blotting. Compared with that control group, (RES) significantly induced inhibited migration...
Impairment of the blood-brain barrier (BBB) could result in secondary cerebral edema and life-threatening pancreatic encephalopathy patients with severe acute pancreatitis (SAP). Mesenchymal stem cells (MSCs) have been widely adopted clinical research because their pleiotropic functions. The aim this study was to investigate impact MSCs on BBB permeability SAP potential mechanisms driving these effects.Sprague-Dawley rats were randomly assigned control, SAP+MSCs groups. Pancreatic impairment...
Long noncoding RNAs play an important role in the occurrence, invasion, as well metastasis of various human cancers, including hepatocellular carcinoma. can affect biological functions carcinoma cells by regulating genes; however, only a small fraction molecular mechanisms long have been elucidated. In present study, lnc AC010973.1 (lnc-ATG9B-4) was first identified microarray analysis from 8 patients with and confirmed quantitative PCR 176 We demonstrated that lnc-ATG9B-4 tightly relative...
Atherosclerosis (As) is a chronic cardiovascular disease characterized by abnormal of lipid accumulation and cholesterol efflux. The present study aimed to investigate whether the micro-RNA (miR)-200b-3p could exacerbate As promoting inhibiting efflux via ATP-binding cassette transporter A1 (ABCA1) in macrophage-derived foam cells. Blood samples from 30 patients with healthy people were collected at Quanzhou First Hospital. RAW264.7 cells used establish using oxidized low-density...
Neurofibromatosis type 1 (NF1) is a progressive neurocutaneous disorder in humans, mainly characterized by café-au-lait macules (CALMs) and neurofibromas. NF1 caused variants of the neurofibromin gene (NF1), which encodes Ras-GTPase-activating protein called neurofibromin. may result loss function elevation cell proliferation tumor formation. In this study, Chinese family with an autosomal dominant inheritance pattern was recruited. Exome sequencing Sanger were performed to discover...
Embryo quality determines the success of in vitro fertilization and embryo transfer (IVF-ET) treatment. Biomarkers for evaluation have some limitations. Apoptosis cumulus cells (CCs) is important ovarian function. PTEN (phosphatase tensin homolog) a well known tumour suppressor gene that functions as mediator apoptosis crucial mammalian reproduction. In present study, we analyzed expression level human CCs aimed to investigate its association with developmental competence IVF treatment...
Abstract Background : Tripartite motif-containing 67 (TRIM67) is an E3 ubiquitin ligase that belongs to the TRIM protein family. We previously reported a relationship between TRIM67 and tumorigenesis. immunostaining results correlated with clinicopathological features. expression was associated tumor size, lymph node metastasis, p-TNM stage, cancer cell differentiation, poor prognosis. promoted proliferation, migration, invasion by positively regulating Notch pathway. Delta like...