A5019284998- Mathematical Biology Tumor Growth
- Cellular Mechanics and Interactions
- Slime Mold and Myxomycetes Research
- Biofuel production and bioconversion
- Retinal Development and Disorders
- Cancer Cells and Metastasis
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Theoretical and Computational Physics
- Pickering emulsions and particle stabilization
- Cell Image Analysis Techniques
- Micro and Nano Robotics
- Microbial Metabolic Engineering and Bioproduction
- Angiogenesis and VEGF in Cancer
- Force Microscopy Techniques and Applications
- RNA Research and Splicing
- Enhanced Oil Recovery Techniques
- Microtubule and mitosis dynamics
- Fractal and DNA sequence analysis
- Enzyme Catalysis and Immobilization
- Advanced Fluorescence Microscopy Techniques
- AI in cancer detection
- Enzyme Production and Characterization
- 3D Printing in Biomedical Research
- Gene Regulatory Network Analysis
Georgia State University
2016-2025
Army Medical University
2020-2025
Southwest Hospital
2020-2025
Zhejiang Cancer Hospital
2025
Chinese Academy of Sciences
2025
Jilin University
2025
Shandong Academy of Sciences
2021-2024
Qilu University of Technology
2020-2024
Hunan International Economics University
2024
Zhengzhou University
2024
The extracellular matrix plays a critical role in orchestrating the events necessary for wound healing, muscle repair, morphogenesis, new blood vessel growth, and cancer invasion. In this study, we investigate influence of topography on coordination multi-cellular interactions context angiogenesis. To do this, validate our spatio-temporal mathematical model angiogenesis against empirical data, within framework, vary density fibers to simulate different tissue environments explore possibility...
Many bacteria can rapidly traverse surfaces from which they are extracting nutrient for growth. They generate flat, spreading colonies, called swarms because resemble of insects. We seek to understand how members any dense swarm spread efficiently while being able perceive and interfere minimally with the motion others. To this end, we investigate myxobacterium, Myxococcus xanthus. Individual M. xanthus cells elongated; always move in direction their long axis; constant motion, repeatedly...
Abstract Liver injury is a core pathological process in the majority of liver diseases, yet genetic factors predisposing individuals to its initiation and progression remain poorly understood. Here we show that asialoglycoprotein receptor 1 (ASGR1), lectin specifically expressed liver, downregulated patients with fibrosis or cirrhosis male mice injury. ASGR1 deficiency exacerbates while overexpression mitigates acetaminophen-induced acute CCl4-induced chronic injuries mice. Mechanistically,...
Extracellular matrix (ECM) strongly influences cellular behaviors, including cell proliferation, adhesion, and particularly migration. In cancer, the rigidity of stromal collagen environment is thought to control tumor aggressiveness, alignment has been linked invasion. While mechanical properties at both single fiber scale bulk gel are quite well studied, how network responds local stress or deformation, structurally mechanically, poorly understood. This intermediate knowledge important...
China is the largest sweet potato producer and exporter in world. Sweet residues (SPRs) separated after extracting starch account for more than 10 % of total dry matter potatoes. In China, 2 million tons SPRs cannot be utilized, unutilized are perishable result environmental pollution. Thus, an environmentally friendly highly efficient process bioethanol production from should developed. The swelling behaviour cellulose causes high-gravity to recalcitrant enzymatic hydrolysis. Cellulase...
Breast ductal carcinoma in situ (DCIS) represent approximately 20% of screen-detected breast cancers. The overall risk for DCIS patients treated with breast-conserving surgery stems almost exclusively from local recurrence. Although a mastectomy or adjuvant radiation can reduce recurrence risk, there are significant concerns regarding patient over-/under-treatment. Current clinicopathological markers insufficient to accurately assess the risk. To address this issue, we developed novel...
Although it is known that ataxia‐telangiectasia mutated ( ATM ) and interleukin 6 IL ‐6) contribute to multiple drug resistance MDR in tumor chemotherapy, the exact role of activation resulting from increased ‐6 expression still unclear. In present study, we demonstrate ‐ NF ‐kappaB pathway, expression, plays a central augmented chemoresistance lung cancer cell lines. This result was supported by expressions Bcl‐2, Mcl‐1, Bcl‐xl, upregulation ‐associated protein ABCG 2. The higher level...
Despite being the most important cellulase producer, cellulase-regulating carbon source signal transduction processes in Trichoderma reesei are largely unknown. Elucidating these is key for unveiling how external sources regulate formation, and ultimately improvement of production biofuel from lignocellulose. In this work, role mitogen-activated protein kinase (MAPK) pathways on formation was investigated. The deletion yeast FUS3-like tmk1 T. leads to improved growth significantly formation....
Abstract Saffron, derived from the stigma of Crocus sativus , is not only a valuable traditional Chinese medicine but also expensive spice and dye. Its yield quality are seriously influenced by its flowering transition. However, molecular regulatory mechanism transition in C. still unknown. In this study, we performed morphological, physiological transcriptomic analyses using apical bud samples during floral process. Morphological results indicated that process could be divided into three...
β- and γ-cytoplasmic actins are ubiquitously expressed in every cell type nearly identical at the amino acid level but play vastly different roles vivo. Their essential embryogenesis mesenchymal migration critically depend on nucleotide sequences of their genes, rather than sequences; however, it is unclear which gene elements underlie this effect. Here we address specific role coding sequence actins' intracellular functions, using stable polyclonal populations immortalized mouse embryonic...
Abstract Multi-enzyme complexes designed based on scaffold proteins are a current topic in molecular enzyme engineering. They have been gradually applied to increase the production of cascades, thereby achieving effective biosynthetic pathways. This paper reviews recent progress design strategy and application multi-enzyme complexes. First, metabolic channels complex introduced, construction strategies emerging years summarized. Then, discovered cascades related discussed, emphasizing...