A5087137290- Mitochondrial Function and Pathology
- Autophagy in Disease and Therapy
- Gut microbiota and health
- Viral-associated cancers and disorders
- Lymphoma Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Probiotics and Fermented Foods
- Multimodal Machine Learning Applications
- Advanced Glycation End Products research
- Metabolomics and Mass Spectrometry Studies
- Flavonoids in Medical Research
- Topic Modeling
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Synthesis of Tetrazole Derivatives
- Sepsis Diagnosis and Treatment
- Pneumonia and Respiratory Infections
- Cancer Genomics and Diagnostics
- Microbial Metabolic Engineering and Bioproduction
- Muscle metabolism and nutrition
- RNA and protein synthesis mechanisms
- CNS Lymphoma Diagnosis and Treatment
- Respiratory viral infections research
- MicroRNA in disease regulation
- Diet, Metabolism, and Disease
- Glutathione Transferases and Polymorphisms
Kunming University of Science and Technology
2023-2025
University Medical Center Groningen
2023-2024
Peking University
2024
Peking University Cancer Hospital
2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024
Chongqing Medical University
2024
Zigong First People's Hospital
2024
Longgang Central Hospital
2024
Northeast Agricultural University
2024
Zhongkai University of Agriculture and Engineering
2023
Abstract Hypertension is a major risk factor for many cardiovascular diseases, which can lead to kidney and heart disease, stroke, premature death. Inhibiting angiotensin‐converting enzyme (ACE) activity an effective method relieve hypertension. Previously, we screened active peptide KYPHVF (KF6) from Boletus griseus‐Hypomyces chrysospermus with excellent ACE inhibitory activity. This study further evaluated the antihypertensive of KF6 in vivo. at 10 mg/kg Captopril (CAP, positive control)...
A biocompatible Dex-MA/PAA hydrogel was prepared through copolymerization of glycidyl methacrylate substituted dextran (Dex-MA) with acrylic acid (AA), which applied as the adsorbent to remove cationic dyes from aqueous solutions.
Dioscin is a steroidal saponin isolated from various kinds of vegetables and herbs possesses biological activities. In this study, the protective effect dioscin on diabetic nephropathy (DN) was explored. metformin (positive control) were administered orally to rats daily for 8 weeks. The biochemistry parameters, pancreas kidney histological changes, oxidative stress, inflammation, apoptosis, autophagy, mitochondrial quality quantity control (mitophagy fission/fusion) measured. Our results...
Voltage responsive micelles prepared from noncovalently grafted amphiphilic polymers were reported. The noncovalent through the host–guest interaction between β-cyclodextrin (β-CD) dextran (Dex-CD) and ferrocene (Fc) terminated poly(ε-caprolactone) (PCL-Fc). Because of presence Fc groups, inclusion complex β-CD can be reversibly controlled by an external stimulating voltage, leading to reversible formation disassembly micelles. occurrence was confirmed cyclic voltammetry (CV) 2D NOESY...
Benefiting from recent advancements in large language models and modality alignment techniques, existing Large Vision-Language Models(LVLMs) have achieved prominent performance across a wide range of scenarios. However, the excessive computational complexity limits widespread use these practical applications. We argue that one main bottleneck is caused by involvement redundant vision sequences model computation. This inspired reassessment efficiency information transmission decoder LVLMs....
Rambutan peel polyphenols effectively improve the lifespan and health of Drosophila . It may exert life-extending effect through preservation balanced redox status gut barrier integrity, as well attenuation Toll/Imd pathway.
Diabetic nephropathy (DN) is a worldwide health problem with increasing incidence. Diosgenin (DIO) natural active ingredient extracted from Chinese yams (Rhizoma dioscoreae) potential antioxidant, anti-inflammatory, and antidiabetic effects. However, the protective effect of DIO on DN still unclear. The present study explored mitigating effects underlying mechanisms in vivo vitro. In current study, rats were induced by high-fat diet streptozotocin then treated metformin (Mef, positive...
Diosgenin (DIO) is a dietary steroid sapogenin possessing multiple biological functions, such as the amelioration of diabetes. However, remission effect DIO on diabetic nephropathy (DN) underlying oxidative stress and cell apoptosis remains unclear. Here, ROS generation its induced was studied in vitro vivo. Renal proximal tubular epithelial (HK-2) cells were treated with (1, 2, 4 µM) under high glucose (HG, 30 mM) conditions. DN rats by high-fat diet combined streptozotocin, followed...
Abstract Prognostic features in advanced perihilar cholangiocarcinoma (pCCA) patients who received first-line hepatic arterial infusion chemotherapy (HAIC) are unknown. The purpose of our study was to develop an applicable score based on serum inflammatory-tumor biomarkers predict the survival pCCA HAIC. In total, 106 were enrolled as training cohort. optimal cutoff values baseline variables defined by receiver operating characteristic method or according previous publications. According...
Scope Diosgenin (DIO) is a natural steroid sapogenin presented in various plants. It exerts anti‐oxidant, anti‐inflammatory and anti‐diabetic nephropathy properties. The present study evaluates the intervention effect of DIO on nephrotoxicity induced by food contaminant 3‐chloro‐1, 2‐propanediol (3‐MCPD) vivo vitro. Methods Results Treatment with (15 mg kg −1 d ) Sprague‐Dawley rats for 4‐week relieves kidney injury 3‐MCPD (30 ). In vitro, (2, 6, 8 µM) alleviates cell apoptosis effectively...
Diosgenin (DIO) is a dietary and phytochemical steroidal saponin representing multiple activities. The present study investigated the protective effect of DIO on type II diabetes-associated nonalcoholic fatty liver disease (D-NAFLD). rat model was established by high-fat diet streptozotocin injection then administered for 8 weeks. results showed that reduced insulin resistance index, improved dyslipidemia, relieved pancreatic damage. decreased hepatic injury markers, including aspartate...
Diosgenin relieved aristolochic acid I-induced renal injury in rats by suppressing apoptosis, maintaining mitochondrial dynamics equilibrium, and inhibiting autophagy.
Extrachromosomal DNAs (eccDNAs) frequently carry amplified oncogenes. This investigation aimed to examine the occurrence and role of eccDNAs in individuals diagnosed with advanced perihilar cholangiocarcinoma (pCCA) who exhibited distinct prognostic outcomes. Five patients poor survival outcomes five better were selected among received first-line hepatic arterial infusion chemotherapy from June 2021 2022. The extracted for high-throughput sequencing. Genes associated differentially expressed...
Patulin (PAT) is a mycotoxin frequently detected in moldy fruits and fruit products. This study investigated the protective role of glutathione (GSH), an antioxidant agent, against PAT-induced cytotoxicity its potential mechanisms HEK293 cells. The obtained results showed that addition GSH significantly increased cell viability decreased apoptosis induced by PAT. Additionally, intracellular ROS mitochondrial overproduction, suppressed decline membrane potential, maintained cellular ATP...