A5101867291- Microbial Natural Products and Biosynthesis
- Heat shock proteins research
- Mitochondrial Function and Pathology
- Circular RNAs in diseases
- Sulfur-Based Synthesis Techniques
- RNA modifications and cancer
- Enzyme Structure and Function
- Organoselenium and organotellurium chemistry
- Fungal Biology and Applications
- Cancer-related molecular mechanisms research
- Drug-Induced Hepatotoxicity and Protection
- Ferroptosis and cancer prognosis
- Fatigue and fracture mechanics
- Marine Sponges and Natural Products
- Autophagy in Disease and Therapy
- Photosynthetic Processes and Mechanisms
- Endoplasmic Reticulum Stress and Disease
- Selenium in Biological Systems
- Genomics and Phylogenetic Studies
- Lung Cancer Treatments and Mutations
- Chemical Synthesis and Reactions
- Heme Oxygenase-1 and Carbon Monoxide
- Organic and Inorganic Chemical Reactions
- MicroRNA in disease regulation
- Bacterial Genetics and Biotechnology
Peking University Third Hospital
2025
Peking University
2025
Soochow University
2022-2024
Southern University of Science and Technology
2024
China University of Geosciences (Beijing)
2019-2024
Chinese Academy of Agricultural Sciences
2017-2023
Biotechnology Research Institute
2017-2023
Taihe Hospital
2021-2023
Jinzhou Medical University
2021-2023
Sichuan University
2023
Glucose-6-phosphate isomerase (GPI) plays an important role in glycolysis and gluconeogenesis. However, the of GPI lung adenocarcinoma (LUAD) remains unclear.All original data were downloaded from The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases integrated via R 3.2.2. expression was explored with TCGA, GEO, Oncomine databases. Immunohistochemistry staining used to analyze clinical specimens. correlations between cancer immune characteristics analyzed TIMER TISIDB...
Patulin (PAT) belongs to the family of food-borne mycotoxins. Our previous studies revealed that PAT caused cytotoxicity in human embryonic kidney cells (HEK293). In present research, we systematically explored detailed mechanism ROS production and clearance PAT-induced HEK293 cell apoptosis. Results showed treatment (2.5, 5, 7.5, 10 μM) for h could regulate expression genes proteins involved mitochondrial respiratory chain complex, resulting dysfunction oxidative phosphorylation induction...
A photocatalytic synthesis of thieno[3,4-c]quinolin-4(5H)-ones/selenopheno[3,4-c]quinolin-4(5H)-ones using diphenyl disulfide or diselenide as sulfur selenium sources was developed. Two C-S/Se bonds and one C-C bond were constructed simultaneously without transition metals other additives.
Four new secondary metabolites, including one spiro[anthracenone-xanthene] derivative aspergiloxathene A (1), penicillide analogue, Δ2′-1′-dehydropenicillide (2), and two phthalide derivatives, 5-methyl-3-methoxyepicoccone (3) 7-carboxy-4-hydroxy-6-methoxy-5-methylphthalide (4), together with four known compounds, yicathin C (5), dehydropenicillide (6), 3-methoxyepicoccone (7), 4-hydroxy-6-methoxy-5-methylphthalide (8), were identified from the marine-derived fungus Aspergillus sp....
Scope Diosgenin (DIO) is a natural steroid sapogenin presented in various plants. It exerts anti‐oxidant, anti‐inflammatory and anti‐diabetic nephropathy properties. The present study evaluates the intervention effect of DIO on nephrotoxicity induced by food contaminant 3‐chloro‐1, 2‐propanediol (3‐MCPD) vivo vitro. Methods Results Treatment with (15 mg kg −1 d ) Sprague‐Dawley rats for 4‐week relieves kidney injury 3‐MCPD (30 ). In vitro, (2, 6, 8 µM) alleviates cell apoptosis effectively...
Diosgenin relieved aristolochic acid I-induced renal injury in rats by suppressing apoptosis, maintaining mitochondrial dynamics equilibrium, and inhibiting autophagy.
Abstract Background Microglial polarization and the subsequent neuroinflammatory response oxidative stress are contributing factors for traumatic brain injury (TBI) plus hemorrhagic shock (HS) induced injury. In present work, we have explored whether Lysine (K)-specific demethylase 4 A (KDM4A) modulates microglia M1 in TBI HS mice. Results Male C57BL/6J mice were used to investigate + model vivo. Lipopolysaccharide (LPS)-induced BV2 cells examine mechanism of KDM4A regulating vitro. We found...
Patulin (PAT) is a mycotoxin frequently detected in moldy fruits and fruit products. This study investigated the protective role of glutathione (GSH), an antioxidant agent, against PAT-induced cytotoxicity its potential mechanisms HEK293 cells. The obtained results showed that addition GSH significantly increased cell viability decreased apoptosis induced by PAT. Additionally, intracellular ROS mitochondrial overproduction, suppressed decline membrane potential, maintained cellular ATP...
Abstract Water stress and hypersensitive response (WHy) domain is typically found as a component of atypical late embryogenesis abundant (LEA) proteins closely associated with resistance to multiple stresses in numerous organisms. Several putative LEA have been identified Deinococcus bacteria; however their precise function remains unclear. This work reports the characterization -specific gene encoding novel WHy domain-containing hydrophobic LEA5C protein (named DrwH) D . radiodurans R1. The...
Summary Late embryogenesis abundant ( LEA ) proteins play a protective role during desiccation and oxidation stresses. 3 are major group characterized by hydrophilic domain HD with highly conserved repeating 11‐amino acid motif. We compared four different orthologs from distant organisms: (i) Dr the extremophilic bacterium Deinococcus radiodurans ; (ii) Ce nematode Caenorhabditis elegans (iii) Yl yeast Yarrowia lipolytica (iv) Bn plant Brassica napus . Circular dichroism spectroscopy showed...
Deinococcus radiodurans adapts to challenging environments by modulating gene expression in response oxidative stress. Recently, bacterial small noncoding RNAs (sRNAs) have been presumed participate the transcriptional or translational regulation of stress-responsive genes. We found 24 sRNAs that may be involved stress D. deep RNA sequencing. Moreover, a typical stress-inducible sRNA, IGR_3053, named OsiA, was predicted bind mRNA katA, katE, and sodC bioinformatics method. An osiA knockout...
Herein, we provide a novel method for the synthesis of 1,3-dibenzenesulfonylpolysulfane (DBSPS), which further reacts with boronic acids to afford thiosulfonates. Commercially available boron compounds greatly expanded range Experimental and theoretical mechanistic investigations suggested that DBSPS could both thiosulfone fragments dithiosulfone fragments, but generated aryl dithiosulfonates were unstable decomposed into
Two new spiro-heterocyclic γ-lactam derivatives, cephalimysins M (1) and N (2), were isolated from the fermentation cultures of marine-derived fungus Aspergillus fumigatus CUGBMF17018. known analogues, pseurotin A (3) FD-838 (4), as well four previously reported helvolic acid 16-O-propionyl-16-O-deacetylhelvolic (5), 6-O-propionyl-6-O-deacetylhelvolic (6), (7), 1,2-dihydrohelvolic (8) also identified. One-dimensional (1D), two-dimensional (2D) NMR, HRMS, circular dichroism spectral analysis...
Head and neck squamous cell carcinoma (HNSCC) refers to an epithelial malignant tumor that originates in the head neck, over 600,000 new cases are reported every year, However, overall prognosis is still poor due local recurrence distant metastasis after surgery. The circ_0032822 has been upregulated human oral carcinoma; however, detailed function or mechanism remains unknown. In this study, we confirmed upregulation of HNSCC tissues. Functionally, overexpression significantly promoted...
Mesenchymal stem cells (MSCs) have favourable outcomes in the treatment of kidney diseases. Pre-B-cell leukaemia transcription factor 1 (PBX1) has been reported to be a regulator self-renewal cells. Whether PBX1 is beneficial MSCs haemorrhagic shock (HS)-induced damage unknown. We overexpressed rat bone marrow-derived mesenchymal (rBMSCs) and human (hBMSCs) treat rats with HS hypoxia-treated proximal tubule epithelial (HK-2), respectively. The results indicated that enhanced homing capacity...
In the course of our efforts to search new secondary metabolites from marine-derived fungi, one hexylitaconic acid derivative, 3-(5-methoxycarbonylpentyl)-4-methylfuran-2,5-dione (1), and two dimeric analogues asperwelwinates A B (2 3), together with ten known compounds, asperitaconic C (4), kotanin (5) orlandin (6), desertorin (7), fonsecinone (8), aurasperone (9), asperpyrones (10 11), aspernigrin (12), pyrophen (13), were isolated a strain Aspergillus welwitschiae CUGBMF180262. The...
Background: Circular RNAs (circRNAs) have recently emerged as a new class of RNAs, highly enriched in the human tissues and very stable within cells, exosomes body fluids. In this study, we aimed to screen plasma cell-free derived circRNAs laryngeal squamous cell carcinoma (LSCC) investigate whether these could predicted LSCC potential biomarkers. Methods: The circRNA microarray was employed with three samples each group dysregulated isolated from samples. top 20 were first selected...
Abstract Background GRAP2 is an adaptor protein involved in leukocyte signal activation; however, the prognostic value of and its correlation with immune infiltration lung adenocarcinoma (LUAD) are unclear. Methods Original data were downloaded from TCGA database Gene Expression Omnibus (GEO) database. expression was analyzed TIMER databases. We evaluated influence on clinical prognosis using Kaplan–Meier plotter, GEO, GEPIA The TISIDB databases used to investigate correlations between...
1,4-/1,3-Regioselective bifunctionalization of 1,3-enynes with selenosulfonates in water under catalyst-free conditions for the construction sulfonyl allene and 1,3-disulfonyl-conjugated dienes respectively have been developed. The reactions feature mild reaction aqueous solution remarkable regioselectivity controlled by substrates.
Two new piperazine-triones lansai E and F (1, 2), together with four known secondary metabolites D (3), 1-N-methyl-(E,Z)-albonoursin (4), imidazo[4,5-e]-1,2,4-triazine (5), streptonigrin (6) were isolated from a deep-sea-derived Streptomycetes sp. strain SMS636. The structures of the compounds confirmed by comprehensive spectroscopic analysis, including HRESIMS, 1D 2D NMR. Compound 4 exhibited moderate antibacterial activities against Staphylococcus aureus methicillin resistant S. (MRSA)...
Hemorrhagic shock (HS) is defined as a reduction in tissue oxygenation and organ dysfunction due to severe blood loss. Lung injury frequent complication of HS. Baicalin, isolated from Radix Scutellariae, has been reported profile the antitumor, anti-oxidative, anti-inflammatory, antibacterial roles various pathological processes. Nevertheless, effects baicalin on HS-induced lung are unclear. This study aims examine therapeutic injury. We first established rat models by withdrawing femoral...