A5100373119- Plant Molecular Biology Research
- Plant nutrient uptake and metabolism
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Plant Reproductive Biology
- Plant-Microbe Interactions and Immunity
- Seed and Plant Biochemistry
- Plant Stress Responses and Tolerance
- Genomics and Phylogenetic Studies
- CRISPR and Genetic Engineering
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Legume Nitrogen Fixing Symbiosis
- Molecular Biology Techniques and Applications
- Plant tissue culture and regeneration
- Photosynthetic Processes and Mechanisms
- Plant Disease Resistance and Genetics
- Genomics and Chromatin Dynamics
- Neurobiology and Insect Physiology Research
- Advanced Welding Techniques Analysis
- Ferroptosis and cancer prognosis
- Wheat and Barley Genetics and Pathology
- Microbial Community Ecology and Physiology
- Soil Carbon and Nitrogen Dynamics
- Plant responses to water stress
Chinese Academy of Sciences
2016-2025
University of Science and Technology of China
1991-2025
Shanghai Jiao Tong University
2023-2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2023-2025
Institute of High Energy Physics
2021-2025
Wuhan University
2023-2025
Renmin Hospital of Wuhan University
2023-2025
Qingdao University of Science and Technology
2024-2025
Shanghai University of Engineering Science
2024-2025
Chongqing Medical University
2023-2025
The CRISPR/Cas9 system has been demonstrated to efficiently induce targeted gene editing in a variety of organisms including plants. Recent work showed that CRISPR/Cas9-induced mutations Arabidopsis were mostly somatic the early generation, although some could be stably inherited later generations. However, it remains unclear whether this will similarly crops such as rice. In study, we tested two rice subspecies 11 target genes for their amenability and determined patterns, specificity...
Melatonin (N-acetyl-5-methoxytryptamine), a well-known animal hormone, is also involved in plant development and abiotic stress responses. In this study, it shown that exogenous application of melatonin conferred improved salt, drought, cold resistances bermudagrass. Moreover, treatment alleviated reactive oxygen species (ROS) burst cell damage induced by stress; activation several antioxidants. Additionally, melatonin-pre-treated plants exhibited higher concentrations 54 metabolites,...
The ability to identify a specific cancer using minimally invasive biopsy holds great promise for improving the diagnosis, treatment selection, and prediction of prognosis in cancer. Using whole-genome methylation data from Cancer Genome Atlas (TCGA) machine learning methods, we evaluated utility DNA differentiating tumor tissue normal four common cancers (breast, colon, liver, lung). We identified markers training cohort 1,619 samples 173 matched adjacent samples. replicated our findings...
Active DNA demethylation is an important part of epigenetic regulation in plants and animals. How active regulated its relationship with histone modification patterns are unclear. Here, we report the discovery IDM1, a regulator Arabidopsis. IDM1 required for preventing hypermethylation highly homologous multicopy genes other repetitive sequences that normally targeted by Repressor Silencing 1 related 5-methylcytosine glycosylases. binds methylated at chromatin sites lacking H3K4 di- or...
Chenopodium quinoa is a halophytic pseudocereal crop that being cultivated in an ever-growing number of countries. Because highly resistant to multiple abiotic stresses and its seed has better nutritional value than any other major cereals, it regarded as future ensure global food security. We generated high-quality genome draft using inbred line the cultivar Real. The experienced one recent duplication about 4.3 million years ago, likely reflecting fusion two parents, addition γ...
DNA methylation is an important epigenetic mark involved in many biological processes. The genome of the climacteric tomato fruit undergoes a global loss due to active demethylation during ripening process. It unclear whether other fruits also associated with demethylation. We characterized single-base resolution methylomes sweet orange fruits. Compared immature fruits, ripe gained at over 30,000 genomic regions and lost about 1,000 regions, suggesting increase ripening. This was correlated...
RNA interference (RNAi) in plants can move from cell to cell, allowing for systemic spread of an antiviral immune response. How this cell-to-cell silencing is regulated currently unknown. Here, we describe that the C4 protein Tomato yellow leaf curl virus inhibit intercellular RNAi. Using viral as a probe, have identified receptor-like kinase (RLK) BARELY ANY MERISTEM 1 (BAM1) positive regulator movement RNAi, and determined BAM1 its closest homolog, BAM2, play redundant role process....
Broomcorn millet (Panicum miliaceum L.) is the most water-efficient cereal and one of earliest domesticated plants. Here we report its high-quality, chromosome-scale genome assembly using a combination short-read sequencing, single-molecule real-time Hi-C, high-density genetic map. Phylogenetic analyses reveal two sets homologous chromosomes that may have merged ~5.6 million years ago, both which exhibit strong synteny with other grass species. contains 55,930 protein-coding genes 339...
Morinda officinalis oligosaccharides (MOO) are an oral drug approved in China for the treatment of depression China. However, MOO is hardly absorbed so that their anti-depressant mechanism has not been elucidated. Here, we show acted on tryptophan → 5-hydroxytryptophan (5-HTP) serotonin (5-HT) metabolic pathway gut microbiota. could increase hydroxylase levels microbiota which accelerated 5-HTP production from tryptophan; meanwhile, inhibited decarboxylase activity, thus reduced 5-HT...
Quinoa grains are gaining increasing popularity owing to their high nutritional merits. However, only limited information is available on the metabolic profiles of quinoa grains. In this study, we determined black, red, and white via an ultraperformance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC-ESI-MS/MS)-based metabolomics. A total 689 metabolites were identified, among which 251, 182, 317 displayed different accumulation patterns in three comparison...
DNA methylation is an important epigenetic mark in many eukaryotic organisms. De novo plants can be achieved by the RNA-directed (RdDM) pathway, where plant-specific DNA-dependent RNA polymerase IV (Pol IV) transcribes target sequences to initiate 24-nt siRNA production and action. The putative binding protein DTF1/SHH1 of Arabidopsis has been shown associate with Pol required for accumulation transcriptional silencing at several RdDM loci. However, extent mechanism DTF1 function unclear. We...
Abstract In Arabidopsis (Arabidopsis thaliana), the ATP-dependent chromatin remodeler PICKLE (PKL) determines expression of genes associated with developmental identity. PKL promotes epigenetic mark trimethylation histone H3 lysine 27 (H3K27me3) that facilitates repression tissue-specific in plants. It has previously been proposed acts indirectly to promote H3K27me3 by promoting POLYCOMB REPRESSIVE COMPLEX2 complex generates H3K27me3. We undertook and immunoprecipitation analyses further...
CHD3 proteins are ATP-dependent chromatin remodelers that contribute to repression of developmentally regulated genes in both animal and plant systems. In animals, this has been linked a multiple subunit complex, Mi-2/NuRD, whose constituents include protein, histone deacetylase, methyl-CpG-binding domain protein. Arabidopsis, PICKLE (PKL) codes for protein acts during germination repress expression seed-associated genes. Repression traits is promoted pkl seedlings by the growth regulator...
Selective, tissue-specific gene expression is facilitated by the epigenetic modification H3K27me3 (trimethylation of lysine 27 on histone H3) in plants and animals. Much remains to be learned about how H3K27me3-enriched chromatin states are constructed maintained. Here, we identify a genetic interaction Arabidopsis thaliana between chromodomain helicase DNA binding remodeler PICKLE (PKL), which promotes enrichment, SWR1-family PHOTOPERIOD INDEPENDENT EARLY FLOWERING1 (PIE1), incorporates...