A5102756241- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Neurogenesis and neuroplasticity mechanisms
- Cancer-related molecular mechanisms research
- Heavy Metal Exposure and Toxicity
- Diet and metabolism studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroscience and Neural Engineering
- Neonatal and fetal brain pathology
- Gene expression and cancer classification
- Adipose Tissue and Metabolism
- Neural dynamics and brain function
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Nicotinic Acetylcholine Receptors Study
- Trace Elements in Health
- Receptor Mechanisms and Signaling
- Adenosine and Purinergic Signaling
- interferon and immune responses
- Circular RNAs in diseases
- Veterinary Medicine and Surgery
- Retinal Development and Disorders
- Blood transfusion and management
- Photoreceptor and optogenetics research
- Lipid metabolism and disorders
Qinghai University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Southern University of Science and Technology
2024
Jinan University
2024
China Academy of Chinese Medical Sciences
2024
Army Medical University
2016-2024
Chinese Academy of Civil Aviation Science and Technology
2024
Jilin Province Tumor Hospital
2019-2024
Central South University
2024
Wuhan Academy of Agricultural Sciences
2023
Chenopodium quinoa is a halophytic pseudocereal crop that being cultivated in an ever-growing number of countries. Because highly resistant to multiple abiotic stresses and its seed has better nutritional value than any other major cereals, it regarded as future ensure global food security. We generated high-quality genome draft using inbred line the cultivar Real. The experienced one recent duplication about 4.3 million years ago, likely reflecting fusion two parents, addition γ...
Broomcorn millet (Panicum miliaceum L.) is the most water-efficient cereal and one of earliest domesticated plants. Here we report its high-quality, chromosome-scale genome assembly using a combination short-read sequencing, single-molecule real-time Hi-C, high-density genetic map. Phylogenetic analyses reveal two sets homologous chromosomes that may have merged ~5.6 million years ago, both which exhibit strong synteny with other grass species. contains 55,930 protein-coding genes 339...
Hippocampal injury-associated learning and memory deficits are frequent hallmarks of brain trauma the most enduring devastating consequences following traumatic injury (TBI). Several reports, including our recent paper, showed that TBI brought on by a moderate level controlled cortical impact (CCI) induces immature newborn neuron death in hippocampal dentate gyrus. In contrast, majority mature neurons spared. Less research has been focused these spared neurons, which may also be injured or...
Abstract Cadmium (Cd) is a persistent environmental toxin and occupational pollutant that considered to be potential risk factor in the development of neurodegenerative diseases. Abnormal mitochondrial dynamics are increasingly implicated damage various neurological pathologies. The aim this study was investigate whether disturbance contributed Cd‐induced neurotoxicity melatonin has any neuroprotective properties. After cortical neurons were exposed 10 μ M cadmium chloride (CdCl 2 ) for...
Descending propriospinal neurons (DPSN) are known to establish functional relays for supraspinal signals, and they display a greater growth response after injury than do the long projecting axons. However, their regenerative is still deficient due failure depart from supportive cellular transplants back into host spinal cord, which contains numerous impediments axon growth. Here we report construction of continuous growth-promoting pathway in adult rats, formed by grafted Schwann cells...
Neuropathic pain is a common cause of after nerve injury, but its molecular basis poorly understood. In post-gene chip microarray effort to identify new target genes contributing neuropathic development, we report here the characterization novel contributor, thrombospondin-4 (TSP4), using model spinal ligation injury. TSP4 mainly expressed in astrocytes and significantly upregulated injury side dorsal cord that correlates with development states. blockade by intrathecal antibodies, antisense...
Following prolonged exposure to hypoxic conditions, for example, due ascent high altitude, aging or stroke, cognitive deficits can develop. The exact nature and genesis of hypoxia-induced remain unresolved. Curcumin has been reported stimulate neurogenesis reduce neuronal degeneration. This study aimed investigate the effect curcumin on in hypoxic-brain injury mice its potential mechanism. Eight-week-old male C57BL/6J were normobaric-hypoxia (13%O2) 14 days establish models. Morris water...
The multifunctional cylindrical inclusion (CI) protein of potyviruses contains ATP binding and RNA helicase activities. As part the viral replication complex, it assists genome replication, possibly by to unwinding duplex. It also functions in cell-to-cell movement, likely via formation conical structures at plasmodesmata (PD) interaction with coat (CP). To further understand role CI infection process, we employed alanine-scanning mutagenesis approach mutate infectious full-length cDNA clone...
Paraquat (PQ) is the most widely used herbicide in world and a well-known potent neurotoxin for humans. PQ exposure has been linked to increase risk of Parkinson's disease (PD). However, mechanism underlying its neurotoxic effects PD pathogenesis unclear. In our present study, C57BL/6J mice treated with manifested severe motor deficits indicated by significant reductions suspension score, latency fall from rotarod, grip strength at 8 weeks after exposure. Pathological hallmarks Parkinsonism...
It is generally considered that stress causes decreased immune function and render fish vulnerable to infection diseases. However, the molecular mechanisms between responses susceptibility infections, especially viral diseases, in remain unknown. Understanding monitoring biological consequences underlying may contribute improvement of animal welfare production efficiency. In this study, long-term exposure a variety stressors, including chasing, overcrowding, restraint stress, air mimicking...
Although adequate intake of manganese (Mn) is essential to humans, Mn in excess neurotoxic. Exposure extremely high doses results "manganism", a condition that exhibits Parkinson-like symptoms. However, the mechanisms underlying its neurotoxic effects Mn-induced parkinsonism pathogenesis are unclear. In this study, 8-week-old male C57BL/6 J mice were injected intraperitoneally with saline and 50 mg/kg MnCl2 respectively once daily for 14 days produce an acute neurotoxicity model....
Striatal cholinergic interneurons are tonically active neurons and respond to sensory stimuli by transiently suppressing firing that is associated with sensorimotor learning. The pause in tonic dependent on dopaminergic activity; however, its cellular mechanisms remain unclear. Here, we report evidence inhibition of hyperpolarization-activated cation current ( I h ) involved this process. In exhibiting regular vitro , exogenous application dopamine caused a prolongation the...
Cadmium (Cd) is known as a widespread environmental neurotoxic pollutant. Cd exposure recently recognized an etiological factor of Parkinson's disease (PD) in humans. However, the mechanism underlying neurotoxicity relation to Parkinsonism pathogenesis unclear. In our present study, C57BL/6 J mice were exposed 100 mg/L CdCl2 drinking water for 8 weeks. It was found caused motor deficits, decreased DA neurons and induced neuropathological changes midbrain. Non-targeted lipidomic analysis...
Objectives This study used (Geographic Information System) GIS technology to analyze the spatiotemporal distribution of influenza incidence in Qinghai from 2009 2023, based on surveillance data. Methods first accessed data sets Province 2023 through Chinese Infectious Disease Surveillance System. Subsequently, trend charts each city and prefecture were employed illustrate trends during period 2023. To explore risks different counties districts, methods including spatial autocorrelation,...
Transfusion of RBC concentrates may cause adverse effects in the recipient, particularly when stored > 2 weeks. Prestorage removal WBCs and platelets (leukoreduction, LR) improves clinical outcome human recipient. As blood ages during storage, progressive alterations structure function cells occur. Changes cell membranes lead to formation microparticles (MPs) blood.The aim study was quantify MP concentration supernatants from canine 11 clinically healthy dogs.Whole units (n = 11) were...
Low physical activity has been identified as a major risk factor for the development of feline obesity and diabetes. This study aimed to evaluate effects increased meal frequency dietary water content on voluntary in cats fed maintain BW. Ten adult lean neutered male were used 2 tests, both crossover studies composed 14-d adaptation period, followed by 7-d measurement from d 15 22 using Actical collars. Cats group housed most day, except times when they individually cages access their diet...
Circular RNAs (circRNAs) are a class of endogenous single-strand RNA transcripts with crucial regulation in human cancers. The objective this study is to investigate the role circ_0082182 CRC and its specific functional mechanism.The quantitative real-time polymerase chain reaction (qRT-PCR) was performed measure levels circ_0082182, microRNA-411 (miR-411) microRNA-1205 (miR-1205). Cell proliferation detected by counting Kit-8 (CCK-8) colony formation assays. Flow cytometry used for...