A5012694324- Botulinum Toxin and Related Neurological Disorders
- Musculoskeletal pain and rehabilitation
- Pain Mechanisms and Treatments
- Hemodynamic Monitoring and Therapy
- Axon Guidance and Neuronal Signaling
- Pain Management and Placebo Effect
- Ion channel regulation and function
- Reliability and Agreement in Measurement
- Metabolism and Genetic Disorders
- Peripheral Nerve Disorders
- Drug-Induced Hepatotoxicity and Protection
- Zebrafish Biomedical Research Applications
- Metabolomics and Mass Spectrometry Studies
- Hippo pathway signaling and YAP/TAZ
Chungnam National University
2019
Convergence Research Center for Diagnosis Treatment and Care System of Dementia
2018
Korea Institute of Science and Technology
1994-2018
Korea University of Science and Technology
2018
Bio-Medical Science (South Korea)
2018
University of California, Irvine
2012
Wooridul Hospital
2010
Although T-type Ca(2+) channels are implicated in nociception, the function of specific subtypes has not been well defined. Here, we compared pain susceptibility mice lacking Ca(V)3.2 subtype (Ca(V)3.2(-/-)) with wild-type littermates various behavioral models to explore roles processing noxious stimuli vivo. In acute mechanical, thermal and chemical tests, Ca(V)3.2(-/-) showed decreased responses mice. also displayed attenuated tonic such as intraperitoneal injections irritant agents...
Neuropathic pain is a common cause of after nerve injury, but its molecular basis poorly understood. In post-gene chip microarray effort to identify new target genes contributing neuropathic development, we report here the characterization novel contributor, thrombospondin-4 (TSP4), using model spinal ligation injury. TSP4 mainly expressed in astrocytes and significantly upregulated injury side dorsal cord that correlates with development states. blockade by intrathecal antibodies, antisense...
Abstract Alcohol use disorder is a chronic relapsing disease. Maintaining abstinence represents major challenge for alcohol‐dependent patients. Yet the molecular underpinnings of alcohol relapse remain poorly understood. In present study, we investigated potential role mammalian target rapamycin complex 1 (mTORC1) in to alcohol‐seeking behavior by using reinstatement previously extinguished conditioned place preference (CPP) response as surrogate paradigm. We found that mTORC1 activated...
To compare the reliability and validity of Korean range motion standard protocol (KRSP) for measuring joint (ROM) with those conventional ROM measurement using a goniometer. We conducted randomized controlled trial involving 91 healthy elderly individuals. compared two strategies to evaluate each standardized protocol: first, KRSP based on Chungnam National University guidelines second, handheld goniometric measurement. In first strategy, 3 examiners (1 rehabilitation doctor, 1 physical...
1. The metabolism of pyrilamine, 2-[4-methoxybenzyl-(2-dimethyiaminoethyl) amino] pyridine, was studied in adult male volunteers after a single oral dose 50 mg.2. Solvent extracts urine obtained with or without enzyme hydrolysis were analysed by gc/ms derivatization MSTFA/TMSCI (N-methyl-N-trimethylsilyl-trifluoroacetamide/trimethyl chlorosilane). structure metabolites determined based on EI mass spectra and confirmed those authentic standards.3. Conjugated identified the O-desmethylpyril...