A5087284184- Hormonal and reproductive studies
- Metabolomics and Mass Spectrometry Studies
- Analytical Chemistry and Chromatography
- Mass Spectrometry Techniques and Applications
- Estrogen and related hormone effects
- Polyamine Metabolism and Applications
- Analytical Methods in Pharmaceuticals
- Hair Growth and Disorders
- Phytoestrogen effects and research
- Amino Acid Enzymes and Metabolism
- Engineering Applied Research
- melanin and skin pigmentation
- Pesticide Residue Analysis and Safety
- Effects and risks of endocrine disrupting chemicals
- Hormonal Regulation and Hypertension
- Pharmacogenetics and Drug Metabolism
- Pharmacological Effects and Assays
- Metabolism and Genetic Disorders
- Cholesterol and Lipid Metabolism
- Pelvic floor disorders treatments
- Fatty Acid Research and Health
- Nutrition, Health and Food Behavior
- Food Quality and Safety Studies
- Nutrition, Genetics, and Disease
- Neuroscience and Neuropharmacology Research
Korea Institute of Science and Technology
2012-2023
Kyung Hee University
2009-2021
University of Science and Technology
2013
Korea University of Science and Technology
2010-2012
Yonsei University
1998-2010
Ajou University
2009
Korea Advanced Institute of Science and Technology
2007-2009
Korea University
2009
Sungkyunkwan University
2009
Jeonbuk National University
2006
Abstract Motivation: For the early detection of cancer, highly sensitive and specific biomarkers are needed. Particularly, in bio-fluids relatively more useful because those can be used for non-biopsy tests. Although altered metabolic activities cancer cells have been observed many studies, little is known about screening. In this study, a systematic method proposed identifying urine samples by selecting candidate from genome-wide gene expression signatures cells. Biomarkers identified...
Abnormalities in steroid hormones are responsible for the development and prevention of endocrine diseases. Due to their biochemical roles system, quantitative evaluation is needed elucidate altered expression steroids. Gas chromatographic-mass spectrometric (GC-MS) profiling 70 urinary steroids, containing 22 androgens, 18 estrogens, 15 corticoids, 13 progestins, 2 sterols, were validated its data visualized using hierarchically clustered heat maps allow "steroid signatures". The devised...
Isoflavones and lignans are phytoestrogens that have recently gained interest as dietary factors related to prostatic diseases. However, no data on the concentrations in prostate tissue humans is available. Therefore, of isoflavones plasma tissues according volume were compared determine their possible effect benign growth.Fasting specimens acquired from 25 men over 50 years age with similar normal habits previous history drug intake could affect levels. The was either during a transurethral...
Abstract A quantitative analysis of polyamines in urine and serum by liquid chromatography–tandem mass spectrometry (LC‐MS/MS) is described. The were carbamylated with isobutyl chloroformate, extracted diethyl ether under pH 9.0, analyzed LC‐MS/MS single reaction monitoring mode. limit quantification was 1 ng/mL based on a signal‐to‐noise ratio >3, the correlation coefficient ( r 2 ) for calibration curves >0.99 both samples. present method applied to samples from 30 breast cancer...
Metabolomics has focused on toxicological applications to (1) understand the mechanisms of toxicity, (2) identify novel biomarkers and (3) provide in vivo assessment animal models through simple fast methods date. The effects nonylphenol (NP) were evaluated after intraperitoneal injection rats with 0, 50, 250 mg kg(-1) day(-1) NP for four consecutive days. In nontargeted approach, different extraction conditions introduced investigate gas chromatography/mass spectrometry (GC/MS). GC/MS data...
Diagnosis techniques using urine are non-invasive, inexpensive, and easy to perform in clinical settings. The metabolites urine, as the end products of cellular processes, closely linked phenotypes. Therefore, metabolome is very useful marker discoveries applications. However, only univariate methods have been used classification studies metabolome. Since multiple genes or proteins would be involved developments complex diseases such breast cancer, compounds including related with diseases,...
ABSTRACT Liver toxicity represents an important healthcare issue because it causes significant morbidity and mortality can be difficult to predict before symptoms appear owing drug therapy or exposure toxicants. Using metabolomic techniques, we discovered common biomarkers for the prediction of hepatotoxicity in rat urine using mass spectrometry. For this purpose, liver was induced by 5 days oral administration carbon tetrachloride (1 ml kg −1 per day), acetaminophen (1000 mg day)...
Alterations of cholesterol metabolism are responsible for vasospastic angina and atherosclerosis. To comprehensively evaluate metabolism, 18 sterols, including cholesterol, 6 cholesteryl esters (CEs), 3 precursors, 8 hydroxycholesterols (OHCs), were simultaneously analyzed using hybrid solid-phase extraction (SPE) purification coupled to high-temperature gas chromatography-mass spectrometry (HTGC-MS). Methanol-based SPE increased the selective extraction, HTGC resulted in a good...
Phyto-oestrogens are plant compounds with both oestrogenic and anti-oestrogenic properties. However, it is not known whether natural phyto-oestrogens beneficial or harmful in human osteoporosis. This study was performed to investigate the relationships between urinary bone mineral density (BMD) Korean postmenopausal women.The subjects were classified into osteoporotic, osteopenic normal groups according their BMD as defined by WHO criteria. We compared of each group studied correlate BMD.The...
Journal Article Analysis of Anabolic Steroids Using GC/MS with Selected Ion Monitoring Get access BongChul Chung, Chung Doping Control Center, Korea Institute Science & Technology, P.O. Box 131, Cheongryang, Seoul, Search for other works by this author on: Oxford Academic PubMed Google Scholar Hea-Young P. Choo, Choo TaeWook Kim, Kim KheeDong Eom, Eom OhSeung Kwon, Kwon Jawon Suh, Suh Jongsoon Yang, Yang Jongsei Park * *Author to whom correspondence should be addressed. Analytical...
Panax ginseng has been reported to have cancer-preventive properties and, through anti-inflammatory, antioxidant, and pro-apoptotic mechanisms, influence gene expression. However, the comparison of Korean white (WG) red (RG) in their apoptotic effects identification selective cellular uptake ginsenosides human breast cancer cells not yet fully understood. In present study, relative nonpolar protopanaxadiol (PPD) class exhibited more cytotoxic efficient on MCF-7 compared with polar...
The incidence rates of urinary bladder cancer continue to rise yearly, and thus new therapeutic approaches early diagnostic markers for are urgently needed. Thus, identifying the key mediators molecular mechanisms responsible survival has valuable implications development therapy. In this study, role BLT2, a receptor leukotriene B4 (LTB4) 12(S)-hydroxyeicosatetraenoic acid (HETE), in 253J-BV cells was investigated. We found that expression BLT2 is highly elevated cells. Also, we observed...