A5019576070- Bone health and osteoporosis research
- Bone health and treatments
- Bone Metabolism and Diseases
- Vitamin D Research Studies
- Parathyroid Disorders and Treatments
- Bone and Joint Diseases
- Hip and Femur Fractures
- Nutrition and Health in Aging
- Peroxisome Proliferator-Activated Receptors
- Regulation of Appetite and Obesity
- Diabetes and associated disorders
- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- Thyroid Cancer Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Wnt/β-catenin signaling in development and cancer
- Biochemical Analysis and Sensing Techniques
- TGF-β signaling in diseases
- Estrogen and related hormone effects
- Developmental Biology and Gene Regulation
- Neuroblastoma Research and Treatments
- Diet and metabolism studies
- Diabetes Management and Research
Yonsei University
2010-2019
Severance Hospital
1995-2014
Bio-Medical Science (South Korea)
2013
Research Institute for Endocrine Sciences
2013
Yonsei University Health System
2012
National Health Insurance Service
2003
East Tennessee State University
2002
Vitamin D status in the Korean population has not been adequately determined.To investigate vitamin and prevalence of insufficiency population, also identify predictors for Korea.The Fourth Korea National Health Nutrition Examination Surveys (KNHANES IV) conducted 2008.3,047 males 3,878 females aged 10 years older selected all 16 administrative districts South Korea.Serum 25-hydroxyvitamin [25(OH)D] levels defined as serum 25(OH)D level less than 20 ng/ml.Vitamin was found 47.3% 64.5%...
OBJECTIVE—Despite the popularity of coronary stenting in artery disease (CAD), restenosis remains a challenging clinical problem. This study evaluated efficacy rosiglitazone for preventing in-stent type 2 diabetic patients. RESEARCH DESIGN AND METHODS—We conducted prospective, randomized, case-controlled trial involving 95 patients with CAD who were randomly assigned to either control or group (48 and 47 patients, respectively). Quantitative angiography (QCA) was performed at entry again...
Abstract Uncontrolled oxidative stress impairs bone formation and induces age-related loss in humans. The FoxO family is widely accepted to play an important role protecting diverse cells from reactive oxygen species (ROS). Activation of FoxO1, the main bone, stimulates proliferation differentiation as well inhibits apoptosis osteoblast lineage cells. Despite little known about how FoxO1 expression regulated. Meanwhile, several recent studies reported that microRNAs (miRNAs) could a by...
Biopsy of Thyroid Nodules: Comparison Three Sets GuidelinesSung Soo Ahn1, Eun-Kyung Kim1, Dae Ryong Kang2, Sung-Kil Lim3, Jin Young Kwak1 and Min Jung Kim1Audio Available | Share
AimsHigh calcium (Ca), phosphate (P), and Ca–P product (CPP) are associated with cardiovascular disease in patients chronic kidney disease. Whether this relationship persists individuals normal function is not yet elucidated. We explored the of serum Ca, P, CPP to coronary atherosclerosis assessed by cardiac computed tomography angiography (cCTA) participants function.
Although mild to moderate chronic kidney disease (CKD) and vitamin D deficiency are prevalent in the elderly population worldwide associated with sarcopenia, their influence on bone mineral density (BMD) has not been determined. The objective of study was determine combined effects CKD BMD relationships sarcopenia PTH levels. This a cross-sectional nationally representative samples 6949 subjects aged 55 years or older from Korea National Health Nutrition Examination Surveys conducted between...
Aim: Type 2 diabetes mellitus (T2DM) is a risk factor for increased arterial stiffness. We evaluated associations between the cardio-ankle vascular index (CAVI) and carotid plaque, intima media thickness (IMT), diabetic microvascular complications in Korean T2DM patients.Methods: conducted retrospective, cross-sectional study of 320 patients without history macrovascular disease or macroalbuminuria. measured 24-hour urinary albumin excretion (UAE) levels performed funduscopic neuropathy...
Bone loss is considered to begin with menopause in women and later life men; however, several recent studies have reported that bone began young adults. There are still discordant results concerning age-related changes mineral density (BMD), especially nonvertebral bone. The objective of the study was investigate BMD Korean youth. This a population-based, cross-sectional from Fourth Korea National Health Nutrition Examination Surveys. A total 10,575 (4,731 males 5,844 females) aged 10–80 yr...
Sox11 deletion mice are known to exhibit developmental defects of craniofacial skeletal malformations, asplenia, and hypoplasia the lung, stomach, pancreas. Despite importance in developing skeleton, role osteogenesis has not been studied yet. In this study, we identified that is an important transcription factor for regulating proliferation survival osteoblast precursor cells as well self-renewal potency mesenchymal progenitor via up-regulation Tead2. Furthermore, also plays segregation...
The systemic treatment with angiogenesis inhibitor has been shown to result in weight reduction and adipose tissue loss various models of obesity. To verify the mechanism CKD-732 (TNP-470 analog) against obesity, we evaluated CKD-732’s peripheral central anti-obesity effects. was injected subcutaneously (s.c.) for 7 days animal intracerebroventricularly (i.c.v.) arcuate nucleus (ARC) lesion mice, ob / normal littermates. Modulation hypothalamic neuropeptide mRNAs after i.c.v. injection ARC...
Phyto-oestrogens are plant compounds with both oestrogenic and anti-oestrogenic properties. However, it is not known whether natural phyto-oestrogens beneficial or harmful in human osteoporosis. This study was performed to investigate the relationships between urinary bone mineral density (BMD) Korean postmenopausal women.The subjects were classified into osteoporotic, osteopenic normal groups according their BMD as defined by WHO criteria. We compared of each group studied correlate BMD.The...
Purpose: Osteoprotegerin (OPG), a potent inhibitor of osteoclastic bone resorption, has variety biological functions that include anti-inflammatory effects.Adipocytes and osteoblasts share common origin, the formation new blood vessels often precedes adipogenesis in developing adipose tissue microvasculature.We examined whether OPG is secreted from adipocytes, therefore contributing to prevention neovascularization protecting intimal inflammation medial calcification.Materials Methods: The...
Background/Aims Although magnetic resonance imaging (MRI) is a good visual modality for the evaluation of pituitary lesions, it has limited value in diagnosis mixed nodules and some cystic lesions. We evaluated usefulness 18F-fluorodeoxyglucose positron emission tomography (FDG PET) patients with Methods 18F-FDG PET MRI were performed simultaneously 32 consecutive The relationships between FDG uptake patterns findings analyzed. Results Of 24 piuitary adenomas, 19 (79.2%) showed increased...
In vitro treatment with a pharmacological dose of simvastatin, potent pro-drug 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, stimulates bone formation. our study, simvastatin stimulated differentiation osteoblasts remarkably in dose-dependent manner, minimal effect on proliferation. To identify the mediators anabolic effects osteoblasts, we tried to and characterize simvastatin-induced proteins by using proteomic analysis. Calcyclin was significantly up-regulated more than 10...