A5013273392- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Management and Research
- Peroxisome Proliferator-Activated Receptors
- Adipokines, Inflammation, and Metabolic Diseases
- Diet, Metabolism, and Disease
- Adipose Tissue and Metabolism
- Cardiovascular Health and Disease Prevention
- Pancreatic function and diabetes
- Diet and metabolism studies
- Cardiovascular Disease and Adiposity
- Diabetes and associated disorders
- Nutrition and Health in Aging
- Lipoproteins and Cardiovascular Health
- Alcohol Consumption and Health Effects
- Nutrition, Health and Food Behavior
- Chronic Kidney Disease and Diabetes
- Pituitary Gland Disorders and Treatments
- Regulation of Appetite and Obesity
- Renal Transplantation Outcomes and Treatments
- Advanced Glycation End Products research
- Nutritional Studies and Diet
- Blood Pressure and Hypertension Studies
Yonsei University
2016-2025
Korea University
2025
St. Vincent's Hospital
2025
Kangbuk Samsung Hospital
2025
Sungkyunkwan University
2025
Seoul National University Bundang Hospital
2025
Samsung Medical Center
2016-2025
Yonsei University Health System
2015-2025
National Health Insurance Service
2003-2025
Catholic University of Korea
2016-2025
The National Health Insurance Service (NHIS) recently signed an agreement to provide limited open access the databases within Korean Diabetes Association for benefit of subjects with diabetes. Here, we present history, structure, contents, and way use data procurement in (NHI) system researchers.The NHIS Korea is a single-payer program mandatory all residents Korea. three main healthcare programs NHI, Medical Aid, long-term care insurance (LTCI) 100% coverage population. has adopted...
Background: Obesity and type 2 diabetes are wellknown risk factors for the development of nonalcoholic fatty liver disease (NAFLD).However, NAFLD is not rare in nonobese, nondiabetic adults.The aim this study was to evaluate metabolic significance adults.Methods: This examined 768 nonobese (body mass index [BMI] [calculated as weight kilograms divided by square height meters], Ն18.5 Ͻ30) (460 normal-weight 308 overweight subjects), individuals older than 30 years who participated a medical...
Sodium-glucose cotransporter 2 (SGLT2) inhibitors reduce cardiovascular events in humans with type diabetes (T2D); however, the underlying mechanism remains unclear. Activation of NLR family, pyrin domain-containing 3 (NLRP3) inflammasome and subsequent interleukin (IL)-1β release induces atherosclerosis heart failure. Here we show effect SGLT2 inhibitor empagliflozin on NLRP3 activity. Patients T2D high risk receive or sulfonylurea for 30 days, activation analyzed macrophages. While...
Sarcopenia is associated with nonalcoholic fatty liver disease (NAFLD). This study investigated whether sarcopenia significant fibrosis in subjects NAFLD. Data from the Korean National Health and Nutrition Examination Surveys 2008‐2011 database were analyzed. NALFD was defined by NAFLD fat score, comprehensive or hepatic steatosis index. Degree of assessed score (NFS), FIB‐4, Forns Significant as FIB‐4 ≥2.67 highest quartile values NFS index (= total appendicular skeletal muscle mass...
Metformin activates both PRKA and SIRT1. Furthermore, autophagy is induced by either the PRKA-MTOR-ULK1 or SIRT1-FOXO signaling pathways. We aimed to elucidate mechanism which metformin alleviates hepatosteatosis examining molecular interplay between SIRT1, PRKA, autophagy. ob/ob mice were divided into 3 groups: one with ad libitum feeding of a standard chow diet, 300 mg/kg intraperitoneal injections, g/d caloric restriction (CR) for period 4 wk. Primary hepatocytes HepG2 cells treated oleic...
Impairment in macroautophagy/autophagy flux and inflammasome activation are common characteristics of nonalcoholic steatohepatitis (NASH). Considering the lack approved agents for treating NASH, drugs that can enhance autophagy modulate pathways may be beneficial. Here, we investigated novel mechanism ezetimibe, a widely prescribed drug hypercholesterolemia, as therapeutic option ameliorating NASH. Human liver samples with steatosis NASH were analyzed. For vitro studies inflammasomes,...
Despite the mechanistic potential of sodium-glucose cotransporter 2 inhibitor (SGLT2i) to improve neurologic outcomes, efficacy SGLT2i in neurodegenerative disorders among patients with type diabetes is not well established. This population-based cohort study aimed investigate association use risks incident dementia and Parkinson disease (PD) diabetes.
This study aimed to investigate the prevalence, management, and comorbidities of diabetes mellitus among Korean adults. Data from Korea National Health Nutrition Examination Survey (2019-2022) were analyzed assess treatment, risk factors, diabetes. Comparisons between young older adults with emphasized. Among aged ≥30 years, prevalence is 15.5% during 2021-2022. Of these, 74.7% aware their condition, 70.9% received antidiabetic only 32.4% achieved glycosylated hemoglobin (HbA1c) <6.5%....
OBJECTIVE—Despite the popularity of coronary stenting in artery disease (CAD), restenosis remains a challenging clinical problem. This study evaluated efficacy rosiglitazone for preventing in-stent type 2 diabetic patients. RESEARCH DESIGN AND METHODS—We conducted prospective, randomized, case-controlled trial involving 95 patients with CAD who were randomly assigned to either control or group (48 and 47 patients, respectively). Quantitative angiography (QCA) was performed at entry again...
Background Non-alcoholic fatty liver disease (NAFLD) is a prevalent and rapidly increasing worldwide; however, no widely accepted screening models to assess the risk of NAFLD are available. Therefore, we aimed develop validate self-assessment score for in general population using two independent cohorts. Methods The development cohort comprised 15676 subjects (8313 males 7363 females) who visited National Health Insurance Service Ilsan Hospital Korea 2008–2010. Anthropometric, clinical,...
Betatrophin/angiopoietin-like protein 8 (ANGPTL8) is a liver-secreted recently identified as potent stimulator of beta cell proliferation in mice. However, it unclear how betatrophin regulated humans with non-alcoholic fatty liver disease (NAFLD). We investigated the role mice and without NAFLD. Serum levels were examined by ELISA 164 subjects, including 96 patients Levels significantly elevated subjects NAFLD compared controls (1.301 ± 0.617 vs. 0.900 0.574 μg/L, P < 0.001), even after...
Acid–base imbalance has been reported to increase incidence of hypertension and diabetes. However, the association between diet-induced acid load cardiovascular disease (CVD) risk in general population not fully investigated. This was a population-based, retrospectively registered cross-sectional study using nationally representative samples 11,601 subjects from Korea National Health Nutrition Examination Survey 2008–2011. Individual CVD evaluated atherosclerotic (ASCVD) equations according...
Nonalcoholic fatty liver disease (NAFLD) and sarcopenia have a close association with an increased risk of atherosclerotic cardiovascular (ASCVD). This study investigated the influence NAFLD on ASCVD risk.Data from 2008-2011 Korean National Health Nutrition Examination Surveys database were analyzed (n = 7,191). The index was calculated using dual-energy x-ray absorptiometry. Sarcopenia defined as lowest quintile value (cutoffs 0.882 for men 0.582 women). comprehensive score ≥40. Liver...
Metformin is known to alleviate hepatosteatosis by inducing 5’ adenosine monophosphate (AMP)-kinase-independent, sirtuin 1 (SIRT1)-mediated autophagy. Dysfunctional mitophagy in response glucolipotoxicities might play an important role hepatosteatosis. Here, we investigated the mechanism which metformin induces through restoration of suppressed Parkin-mediated mitophagy. To this end, our ob/ob mice were divided into three groups: (1) ad libitum feeding a standard chow diet; (2)...
: Nonalcoholic fatty liver disease (NAFLD) and obesity are independently associated with an increased risk for atherosclerotic cardiovascular (ASCVD), the leading cause of mortality in patients NAFLD. Many NAFLD lean, but their ASCVD compared to obese subjects is unclear.Data from 2008 2011 Korea National Health Nutrition Examination Surveys database were analyzed (n=4,786). was defined as a comprehensive score ≥40 or fat ≥-0.640. evaluated using American College Cardiology/ Heart...
Abstract Background The effect of ezetimibe, Niemann-Pick C1-like 1 inhibitor, on liver fat is not clearly elucidated. Our primary objective was to evaluate the efficacy ezetimibe plus rosuvastatin versus monotherapy reduce using magnetic resonance imaging-derived proton density fraction (MRI-PDFF) in patients with non-alcoholic fatty disease (NAFLD). Methods A randomized controlled, open-label trial 70 participants NAFLD confirmed by ultrasound who were assigned receive either 10 mg 5 daily...