A5038422571- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Treatment and Management
- Diabetes Management and Research
- Metabolism, Diabetes, and Cancer
- Liver Disease Diagnosis and Treatment
- Lipoproteins and Cardiovascular Health
- Pancreatic function and diabetes
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Bone health and osteoporosis research
- Diabetes Management and Education
- Nutritional Studies and Diet
- Blood Pressure and Hypertension Studies
- Diet, Metabolism, and Disease
- Diabetes and associated disorders
- Adipose Tissue and Metabolism
- Body Composition Measurement Techniques
- Nutrition and Health in Aging
- Vitamin D Research Studies
- Growth Hormone and Insulin-like Growth Factors
- Natural Antidiabetic Agents Studies
- Traditional Chinese Medicine Studies
- Cardiovascular Disease and Adiposity
- Artificial Intelligence in Healthcare
- Cancer, Lipids, and Metabolism
Kyung Hee University Hospital at Gangdong
2015-2024
Kyung Hee University
2013-2024
Jeonju University
2024
Seonam University
2019
Gangdong University
2017
Samsung Medical Center
2007-2016
Eulji General Hospital
2016
Uijeongbu St. Mary's Hospital
2016
Catholic University of Korea
2016
Eulji University
2016
The association between sarcopenia and cardiovascular disease (CVD) in elderly people has not been adequately assessed. aim of this study was to investigate whether CVD is more prevalent subjects with independent other well-established risk factors older Korean adults.This utilized the representative population data from Korea National Health Nutrition Examination Survey (KNHANES) which conducted 2009. Subjects than 65 years age appendicular skeletal muscle mass (ASM) determined by dual...
Recent human studies support the notion that serum osteocalcin increases beta-cell proliferation and insulin secretion, improves sensitivity. However, no study has examined effects of gamma-carboxylation status on these associations or determined role uncarboxylated in glucose metabolism humans.The aim this was to determine association between function sensitivity humans. As many as 199 men, aged 25-60 years (mean age, 47 years), who had never been treated with lowering agents, were enrolled...
Abstract Osteoblasts and adipocytes are differentiated from common mesenchymal stem cells (MSCs) in processes which tightly controlled by various growth factors, signaling molecules, transcriptional factors microRNAs. Recently, chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) was identified as a critical regulator of MSC fate. In the present study, we aimed to identify some microRNAs (miR), target COUP-TFII, determine effects on MSCs During osteoblastic or adipocytic...
OBJECTIVE We investigated the efficacy of an integrated digital health care platform with artificial intelligence (AI)–based dietary management in adults type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS In this 48-week, open-label, randomized, multicenter clinical trial, overweight or obese T2D were randomly assigned to one three groups a 1:1:1 ratio: group A received routine care; B used by themselves; and C feedback from medical staff intermittently applied personal continuous glucose...
Abstract Aims This study aims to compare the preventive effect of low- or moderate-statin with ezetimibe combination therapy and high-intensity statin monotherapy on cardiovascular disease (CVD) all-cause death in a real-world setting. Methods results Using Korean National Health Insurance Service datasets, two cohorts comparing moderate-intensity were constructed by 1:1 propensity score matching procedure. Primary outcome was composite myocardial infarction (MI), stroke, death. Secondary an...
It has been reported that peroxisome proliferator-activated receptor (PPAR)-γ and their synthetic ligands have direct effects on pancreatic β-cells. We investigated whether PPAR-γ activation stimulates insulin secretion through the up-regulation of GPR40 in β-cells.Rat insulinoma INS-1 cells primary rat islets were treated with rosiglitazone (RGZ) and/or adenoviral overexpression. OLETF rats RGZ.PPAR-γ RGZ overexpression increased free fatty acid (FFA) expression, intracellular calcium...
In agreement with the results of animal studies, plasma osteocalcin level is positively associated improved glucose tolerance and insulin secretion sensitivity. addition, inversely development diabetes; however, adiponectin may not be involved in osteocalcin-mediated energy metabolism humans.Recent studies have suggested crosstalk between bone through osteocalcin. The aims this study were to determine whether or sensitivity, association dependent on humans.Four hundred twenty-five subjects,...
Abstract Background Although an association between low-level environmental heavy metal exposure and the incidence of metabolic syndrome (MS) has been hypothesized, little research on this topic conducted a population-wide level. Methods We analyzed MS status whole blood lead, mercury, cadmium, manganese, creatinine-adjusted urine arsenic concentrations in 1,405 subjects, ≥ 20 years age, who were registered for Korea National Health Nutrition Examination Survey, 2008. Results Various...
Atherogenic dyslipidemia is frequently observed in persons with a greater amount of visceral adipose tissue (VAT). However, it still uncertain whether VAT independently associated the future development atherogenic dyslipidemia.The aim this study was to determine baseline and changes subcutaneous (SAT) are independent lipid levels standard anthropometric indices.Community-based prospective cohort 5 years follow-up.A total 452 Japanese Americans (240 men, 212 women), aged 34-75 were assessed...
This study aimed to develop and validate a machine learning (ML) model tailored the Korean population with type 2 diabetes mellitus (T2DM) provide superior method for predicting development of cardiovascular disease (CVD), major chronic complication in these patients. We used data from two cohorts, namely discovery (one hospital; n = 12,809) validation (two hospitals; 2019) recruited between 2008 2022. The outcome interest was presence or absence CVD at 3 years. selected various ML-based...
It has been suggested that there is an association between environmental, low-level arsenic exposure and the risk of diabetes mellitus (DM), but little research conducted. Here, glucose tolerance status urinary creatinine adjusted total concentrations were analyzed in 3,602 subjects ≥ 20 yr age who registered for Korea National Health Nutrition Examination Survey, 2008-2009. Various demographic parameters associated with concentrations. After adjusting these variables, DM significantly...
Background The original homeostasis model assessment (HOMA1) and the updated HOMA (HOMA2) have been used to evaluate insulin resistance (IR) β-cell function, but little is known about usefulness of HOMA2 for prediction diabetes in Koreans. aim this study was demonstrate as a predictor type 2 mellitus Koreans without diabetes. Methods population consisted 104,694 enrolled at health checkup program followed up from 2001 2012. Participants were divided into normal glucose tolerance (NGT) group...
The aims of this study were to investigate whether circulating irisin is associated with favorable metabolic parameters and how the association differs according body composition in humans. A total 424 subjects (233 men 191 women), aged 23–73 years (mean age 47.1 years), enrolled from Seoul Metro City Diabetes Prevention Program. Body was determined using an impedance analyzer, serum level measured a commercial kit. Serum correlated including less obese, lower blood pressure glucose levels...
G protein-coupled receptor 119 (GPR119) is predominantly expressed in pancreatic β-cells, enteroendocrine cells, and the liver. It a novel therapeutic for dyslipidemia type 2 diabetes. DA-1241, GPR119 agonist, improves glucose tolerance by inhibiting gluconeogenesis enhancing insulin secretion. mitigates hepatic inflammation NFĸB signaling. However, mechanism which DA-1241 ameliorates nonalcoholic fatty liver disease (NAFLD) remains unknown. We hypothesized that steatosis inducing autophagy...
<p dir="ltr">G protein-coupled receptor 119 (GPR119) is predominantly expressed in pancreatic β-cells, enteroendocrine cells, and the liver. It a novel therapeutic for dyslipidemia type 2 diabetes. DA-1241, GPR119 agonist, improves glucose tolerance by inhibiting gluconeogenesis enhancing insulin secretion. mitigates hepatic inflammation NFκB signaling. However, mechanism which DA-1241 ameliorates nonalcoholic fatty liver disease (NAFLD) remains unknown. We hypothesized that steatosis...
<p dir="ltr">G protein-coupled receptor 119 (GPR119) is predominantly expressed in pancreatic β-cells, enteroendocrine cells, and the liver. It a novel therapeutic for dyslipidemia type 2 diabetes. DA-1241, GPR119 agonist, improves glucose tolerance by inhibiting gluconeogenesis enhancing insulin secretion. mitigates hepatic inflammation NFκB signaling. However, mechanism which DA-1241 ameliorates nonalcoholic fatty liver disease (NAFLD) remains unknown. We hypothesized that steatosis...
Primary thyroid lymphoma is a very rare tumor and its prevalence approximately 0.1% of all cancers in Korea. Its clinical experience limited not familiar to physicians. Therefore, we performed this study investigate the characteristics primary Koreans. We retrospectively analyzed medical records 44 patients with from 1991 2006 at four major referral hospitals Out patients, eight were male 36 female their average age was 57 years. Fifty-six percent had underlying Hashimoto's thyroiditis. All...