A5032665309- Pancreatic function and diabetes
- Diabetes Management and Research
- Heart Rate Variability and Autonomic Control
- Metabolism, Diabetes, and Cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes and associated disorders
- Diabetes Treatment and Management
- Thyroid Cancer Diagnosis and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Thyroid Disorders and Treatments
- Blood Pressure and Hypertension Studies
- Liver Disease Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Cardiovascular Function and Risk Factors
- Diet and metabolism studies
- Cardiovascular Health and Disease Prevention
- Neuroendocrine Tumor Research Advances
- Cardiovascular and exercise physiology
- Cardiovascular Disease and Adiposity
- Lipoproteins and Cardiovascular Health
- Nutritional Studies and Diet
- Adipokines, Inflammation, and Metabolic Diseases
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diet, Metabolism, and Disease
- Adrenal and Paraganglionic Tumors
Eulji University
2016-2024
Eulji University Hospital
2021-2022
Sungkyunkwan University
2012-2021
Samsung Medical Center
2012-2021
University of Ulsan
2019-2020
Ulsan College
2019-2020
Soonchunhyang University Hospital
2020
Gangneung Asan Hospital
2017-2020
Eulji General Hospital
2016
Uijeongbu St. Mary's Hospital
2016
The outcome after living donor renal transplantation is superior to that for deceased transplantation, but the results are not uniformly successful. factors responsible variable have been well defined.UK Transplant Registry data were analyzed determine outcomes of 3142 first adult kidney transplants from donors (71% genetically related and 29% unrelated) performed between 2000 2007 inclusive. Kaplan-Meier survival estimates determined, might be associated with graft patient using Cox...
Nonalcoholic fatty liver disease (NAFLD) has been associated with relative skeletal muscle mass in several cross-sectional studies. We explored the effects of and changes over time on development incident NAFLD or resolution baseline a large, longitudinal, population-based 7-year cohort study. included 12,624 subjects without 2943 who underwent health check-up examinations. A total 10,534 2631 were analysis year. Subjects defined as having by hepatic steatosis index, previously validated...
Islet amyloid accumulation is a hallmark of human type 2 diabetes (T2D). In contrast to islet polypeptide (hIAPP), murine (mIAPP) does not exhibit amyloidogenic propensity. Because autophagy important in the clearance amyloid-like proteins, we studied transgenic mice with β cell–specific expression hIAPP evaluate contribution T2D-associated hIAPP. hIAPP, deficiency resulted development overt diabetes, which was observed expressing alone or lacking alone. Furthermore, lack hIAPP-expressing...
It is presently unclear whether glycemic variability associated with diabetic cardiovascular autonomic neuropathy (CAN). The aim of this study was to examine short- and/or long-term (GV) contribute CAN.A total 110 patients type 2 diabetes who underwent three-day continuous glucose monitoring (CGM) completed five standardized tests. Short-term GV measured by the standard deviation (SD), coefficient variation (CV) glucose, and mean amplitude excursions (MAGE) in CGM. HbA1c calculated from...
Whereas NF-κB has potent antiapoptotic function in most cell types, it was reported that pancreatic β cells serves a proapoptotic and may contribute to the pathogenesis of autoimmune type 1 diabetes. To investigate role diabetes, we produced transgenic mice expressing nondegradable form IκBα (RIP-mIκBα mice). these were more susceptible killing by TNF-α plus IFN-γ but resistant IL-1β than normal cells. Similar results obtained with lacking IκB kinase β, protein required for activation....
OBJECTIVE—Imatinib has been reported to induce regression of type 2 diabetes in chronic leukemia patients. However, the mechanism amelioration by imatinib is unknown, and it uncertain whether effects on itself without other confounding diseases like leukemia. We studied effect db/db mice investigated possible mechanism's underlying improved glycemic control imatinib. RESEARCH DESIGN AND METHODS—Glucose tolerance insulin tests were done after daily intraperitoneal injection 25 mg/kg into...
Skeletal muscle mass was negatively associated with metabolic syndrome prevalence in previous cross-sectional studies. The aim of this study to investigate the impact baseline skeletal and changes over time on development a large population-based 7-year cohort study. A total 14,830 11,639 individuals who underwent health examinations at Health Promotion Center Samsung Medical Center, Seoul, Korea were included analyses those from 1 year, respectively. estimated by bioelectrical impedance...
We aimed to evaluate the effects of carnitine-orotate complex in patients with nonalcoholic fatty liver disease (NAFLD) and diabetes.Eight hospitals Korea participated this randomized, controlled, double-blind trial diabetes NAFLD. Seventy-eight were randomly assigned a 1:1 ratio receive (824 mg, three times daily) or matching placebo. The primary study outcome was decline alanine aminotransferase (ALT) normal range. Secondary outcomes change ALT, radiological hepatic steatosis, parameters...
Objective Although an exaggerated systolic blood pressure (SBP) response to exercise is a predictor of future hypertension and cardiovascular mortality, the underlying mechanisms are not fully understood. We tested hypothesis that SBP associated with carotid atherosclerosis in cross-sectional study 9073 healthy men (aged 47.8 ± 8.8 years). Methods Exaggerated was defined as 210 mmHg or greater during maximal treadmill test. Carotid stenosis than 25% intima–media thickness 1.2 mm using B-mode...
One aspect of the effects metformin on glucagon-like peptide (GLP)-1 might be associated with mechanism by which cross talk between insulin and Wnt signaling enhances GLP1 secretion, due to action as an sensitizer. However, this remains completely unknown. In study, we have investigated mechanisms signaling. enhancement meformin was determined in human NCI-H716 intestinal L-cells hyperglycemic db/db mice treated (0.25 0.5 mM and/or 12.5 mg/kg body weight) for 24 h 2 months. Metformin...
Thyroid hormones are important regulators of glucose homeostasis. However, the association between thyroid within reference range and type 2 diabetes mellitus (T2DM) remains unclear. The aim this study was to clarify incidence T2DM according baseline levels changes thyrotropin (TSH) (free thyroxine triiodothyronine) in euthyroid subjects.Among participants who consecutively underwent function tests 2006 2012 through a yearly health checkup program, 6235 subjects (3619 men 2616 women) without...
We tested the hypothesis that higher levels of bilirubin, a bile pigment with antioxidant properties, are associated decreased risk cardiovascular disease (CVD). This study analyzed data from Korean Health and Genome Study to examine association between serum total bilirubin (TB) on CVD death. Serum TB was measured in 8,844 subjects (4,196 males 4,648 females) evaluated for development new onset 2001 2012 (mean 8.1 years follow-up). During follow-up period, 689 cases incident (7.8%) were...
Abstract Background The purpose of this study was to establish the association between continuous glucose monitoring (CGM)‐defined glycaemic variability (GV) and cardiovascular autonomic neuropathy (CAN) in type 1 diabetes independent mean examine relative contribution each internationally standardized CGM parameter association. Materials methods This included 80 adults with who underwent 3‐day function tests within 3 months. degree parameters CAN, defined as at least two abnormal...
Peroxisome proliferator-activated receptors (PPARs) are a nuclear hormone receptor superfamily of ligand-activated transcription factors, and the PPARgamma subtype regulates adipocyte differentiation, lipid metabolism, insulin sensitivity. There have been several reports on relationship between PPARgamma2 Pro12Ala genotype obesity or diabetes in Caucasians. The objective this study was to examine mutation Korean subjects. Two hundred twenty-nine subjects, including 111 obese subjects (body...
Recent studies incriminating tumor necrosis factor (TNF)-α as the final effector in pancreatic β-cell death type 1 diabetes underscore potential role of TNF-α-dependent NF-κB activation an important modulator autoimmune diabetes. Although nuclear (NF)-κB has been implicated protection target cells against apoptosis by a variety effectors, its islet cell is not clear. We studied using γ-interferon (IFN-γ)/TNF-α synergism model we had previously reported. TNF-α induced inhibitor κB (IκB)...
We have reported important roles for signal transducer and activator of transcription-1 (STAT1) in pancreatic beta-cell death by cytokines vitro. However, vivo evidence supporting the role STAT1 natural type 1 diabetes has not been reported. studied whether plays an development diabetes.We produced nonobese diabetic (NOD)/STAT1(-/-) mice backcrossing diabetes.STAT1(-/-) islet cells were resistant to interferon (IFN)-gamma/tumor necrosis factor (TNF)-alpha or IFN-gamma/interleukin (IL)-1 beta...
Although many studies have reported an association between total white blood cell count and metabolic syndrome, relatively few reports are available on the differential counts syndrome. The medical records of 15,654 subjects (age, median 46, range 14-90 yr; 8,380 men 7,274 women) who visited Center for Health Promotion were investigated. It was found that as (WBC) WBC increased frequencies diabetes, hypertension, obesity, dyslipidemia, syndrome also increased. Moreover, these significant...
We have reported that apoptotic β cells undergoing secondary necrosis, called "late (LA) cells," stimulated APCs and induced diabetogenic T cell priming through TLR2, which might be one of the initial events in autoimmune diabetes. Indeed, development diabetes were significantly inhibited TLR2-null NOD mice, suggesting possibility TLR2 blockade could used to inhibit Because prolonged TLR stimulation can induce tolerance, we investigated whether repeated administration affects responses LA...