A5101737685- Liver Disease Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Diet, Metabolism, and Disease
- Diabetes Management and Research
- Alcohol Consumption and Health Effects
- Thyroid Disorders and Treatments
- Pancreatic function and diabetes
- Growth Hormone and Insulin-like Growth Factors
- Thyroid Cancer Diagnosis and Treatment
- Diet and metabolism studies
- Diabetes and associated disorders
- Pituitary Gland Disorders and Treatments
- Heart Rate Variability and Autonomic Control
- Vitamin D Research Studies
- Nutritional Studies and Diet
- Diabetes Management and Education
- Thyroid and Parathyroid Surgery
- Lipoproteins and Cardiovascular Health
- Gout, Hyperuricemia, Uric Acid
- Liver Disease and Transplantation
- Adipose Tissue and Metabolism
- Pancreatitis Pathology and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
Sungkyunkwan University
2016-2025
Samsung (South Korea)
2016-2025
Samsung Changwon Hospital
2014-2024
Keimyung University Dongsan Medical Center
2019
Keimyung University
2019
Changwon National University
2018
Samsung Medical Center
2011-2016
Kangbuk Samsung Hospital
2010-2012
Samsung Advanced Institute of Technology (South Korea)
2008
Nonalcoholic fatty liver disease (NAFLD) has been associated with relative skeletal muscle mass in several cross-sectional studies. We explored the effects of and changes over time on development incident NAFLD or resolution baseline a large, longitudinal, population-based 7-year cohort study. included 12,624 subjects without 2943 who underwent health check-up examinations. A total 10,534 2631 were analysis year. Subjects defined as having by hepatic steatosis index, previously validated...
We evaluated the association of regular physical exercise with presence non-alcoholic fatty liver disease (NAFLD) and enzymes in relation to obesity insulin resistance.A cross-sectional analysis was conducted 72,359 healthy Korean adults without diabetes who participated a comprehensive health check-up. Subjects have been exercising regularly (more than 3 times per week, at least for 30 minutes each time consecutive month) were categorized into group. All subjects deciles based on their body...
The effects of exendin-4 on Sirt1 expression as a mechanism reducing fatty liver have not been previously reported. Therefore, we investigated whether the beneficial treatment are mediated via in high-fat (HF) diet-induced obese C57BL/6J mice and related cell culture models. Exendin-4 decreased body weight, serum free acid (FA), triglyceride levels HF-induced mice. Histological analysis showed that reversed hepatic accumulation lipids inflammation. increased mRNA protein its downstream...
To evaluate whether there is a difference in the association between nonalcoholic fatty liver disease (NAFLD) and incident diabetes based on presence of impaired fasting glucose.A total 7,849 individuals (5,409 men 2,440 women) without diabetes, who underwent comprehensive health check-ups annually for 5 years, were categorized into four groups by glucose NAFLD at baseline. The was evaluated separately with normal glucose.For 4 incidence group 9.9% compared 3.7% non-NAFLD group,...
Background Non-alcoholic fatty liver disease (NAFLD) is a prevalent and rapidly increasing worldwide; however, no widely accepted screening models to assess the risk of NAFLD are available. Therefore, we aimed develop validate self-assessment score for in general population using two independent cohorts. Methods The development cohort comprised 15676 subjects (8313 males 7363 females) who visited National Health Insurance Service Ilsan Hospital Korea 2008–2010. Anthropometric, clinical,...
OBJECTIVES: A cross-sectional analysis was conducted in healthy, nondiabetic Korean adults to assess the prevalence of nonalcoholic fatty liver disease (NAFLD), compare NAFLD across different glycemic ranges as assessed by glycosylated hemoglobin (HbA1c), and examine impact on insulin resistance relation HbA1c levels. METHODS: After rigorous exclusion criteria, final number subjects who participated a comprehensive health status checkup program 99,969. All were classified into four...
Although papillary thyroid microcarcinoma (PTMC) has a favourable long-term prognosis, disease recurrence after initial treatment remains problem and controversy exists regarding the role of radioactive iodine (RAI) ablation in PTMC. We performed this study to evaluate effect RAI on patients with PTMC.Between 1994 2004, 2579 underwent surgery for cancer at Samsung Medical Center. Among these patients, 704 PTMC presumed disease-free were followed up (median, 64 months; range, 1-185 months)....
Skeletal muscle mass was negatively associated with metabolic syndrome prevalence in previous cross-sectional studies. The aim of this study to investigate the impact baseline skeletal and changes over time on development a large population-based 7-year cohort study. A total 14,830 11,639 individuals who underwent health examinations at Health Promotion Center Samsung Medical Center, Seoul, Korea were included analyses those from 1 year, respectively. estimated by bioelectrical impedance...
We aimed to evaluate the effects of carnitine-orotate complex in patients with nonalcoholic fatty liver disease (NAFLD) and diabetes.Eight hospitals Korea participated this randomized, controlled, double-blind trial diabetes NAFLD. Seventy-eight were randomly assigned a 1:1 ratio receive (824 mg, three times daily) or matching placebo. The primary study outcome was decline alanine aminotransferase (ALT) normal range. Secondary outcomes change ALT, radiological hepatic steatosis, parameters...
Traditional lipid measures are known to be associated with incident type 2 diabetes.Our objective was assess the independent association between profiles and development of diabetes in nondiabetic Korean subjects over a 4-yr period.A total 5577 Koreans without who underwent consecutive comprehensive health check-ups annually for 5 yr were enrolled. We measured concentrations cholesterol (TC), triglyceride (TG), apolipoprotein B (apoB), A-I, low-density lipoprotein (LDL-C), high-density...
We aimed to examine the relationship between iron status and hypertension as few studies have addressed this.We analyzed association ferritin/total iron-binding capacity (TIBC) subsequent development of hypertension. A total 8,580 men who visited Health Promotion Center for a medical checkup in 2005 were followed-up after 4 years.Of not hypertensive at baseline, 818 found be 4-year follow-up. Compared with those remained normotensive, these subjects had higher levels ferritin TIBC but no...
Background: Iodine in iodinated contrast agents (ICAs) interferes with radioactive iodine treatment (RAIT) and diagnostic scans patients differentiated thyroid carcinoma (DTC) because it can compete 131I. Published guidelines recommend delaying RAIT for three to four months who have been exposed ICA. Spot urinary concentration is a useful marker reflect the body pool. We investigated impact of ICAs administered at preoperative computed tomography (CT) scan on pool determine proper time...
Thyroid hormones are important regulators of glucose homeostasis. However, the association between thyroid within reference range and type 2 diabetes mellitus (T2DM) remains unclear. The aim this study was to clarify incidence T2DM according baseline levels changes thyrotropin (TSH) (free thyroxine triiodothyronine) in euthyroid subjects.Among participants who consecutively underwent function tests 2006 2012 through a yearly health checkup program, 6235 subjects (3619 men 2616 women) without...
Background: Serum albumin has been suggested to be associated with insulin resistance.We evaluated the association between serum concentration and also investigated whether level an independent effect on development of diabetes.Methods: In our study, 9,029 subjects without diabetes, who underwent comprehensive health check-ups annually for 5 years, were categorized into tertiles based their levels at baseline.The odds ratio (OR) prevalence resistance, defined as top quartile homeostasis...
Recent studies report the importance of metabolic health beyond obesity. The aim this study is to compare risk for diabetes development according different status and obesity over a median follow-up 48.7 months.6,748 non-diabetic subjects (mean age 43 years) were divided into four groups baseline status: metabolically healthy non-obese (MHNO), obese (MHO), unhealthy (MUHNO) (MUHO). Being was defined by having less than 2 components among 5 components, that is, high blood pressure, fasting...
Aim Serum albumin concentration is associated with both type 2 diabetes and metabolic syndrome (MetS). We sought to investigate whether baseline serum change in could be independent risk factors for prediabetes subjects without MetS. further examined the effect of on progression overt who developed prediabetes. Methods Among 10,792 participants MetS consecutively underwent yearly health check-ups over six years, 9,807 incident were enrolled this longitudinal retrospective study. The...
Because patients with new-onset diabetes mellitus (DM) have a significantly increased likelihood of association pancreatic cancer, we need to select the subgroup diabetic who more chance cancer.We retrospectively reviewed medical records case group (151 cancer DM) and control (302 DM without cancer).Compared group, were older, had weight loss, lower usual body mass index (BMI), family history (3.3% vs. 0.7%; P=0.044), less (13.9% 37.4%; P<0.001). If patient did not DM, he was age older than...