A5100324398- Diabetes Management and Research
- Diabetes Treatment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolism, Diabetes, and Cancer
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Diabetes and associated disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes Management and Education
- Parathyroid Disorders and Treatments
- Pancreatic function and diabetes
- Medical Imaging and Pathology Studies
- Muscle metabolism and nutrition
- Thyroid and Parathyroid Surgery
- Thyroid Disorders and Treatments
- Pituitary Gland Disorders and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Function and Risk Factors
- Exercise and Physiological Responses
- Nitric Oxide and Endothelin Effects
- Cancer, Hypoxia, and Metabolism
- Fibroblast Growth Factor Research
- Magnesium in Health and Disease
Sungkyunkwan University
2007-2018
Kangbuk Samsung Hospital
2008-2018
Yeungnam University
2011
Hallym University
1997-2007
Eulji University
2006
Hallym University Sacred Heart Hospital
2006
We evaluated the association of regular physical exercise with presence non-alcoholic fatty liver disease (NAFLD) and enzymes in relation to obesity insulin resistance.A cross-sectional analysis was conducted 72,359 healthy Korean adults without diabetes who participated a comprehensive health check-up. Subjects have been exercising regularly (more than 3 times per week, at least for 30 minutes each time consecutive month) were categorized into group. All subjects deciles based on their body...
To evaluate whether there is a difference in the association between nonalcoholic fatty liver disease (NAFLD) and incident diabetes based on presence of impaired fasting glucose.A total 7,849 individuals (5,409 men 2,440 women) without diabetes, who underwent comprehensive health check-ups annually for 5 years, were categorized into four groups by glucose NAFLD at baseline. The was evaluated separately with normal glucose.For 4 incidence group 9.9% compared 3.7% non-NAFLD group,...
To assess the relationship between 1,5-anhydroglucitol (AG) levels, which are a marker of glycemic control, and stages chronic kidney disease (CKD).This was cross-sectional study with 269 subjects type 2 diabetes who were divided into four groups based on estimated glomerular filtration rate (eGFR) using Modification Diet in Renal Disease (eGFR(MDRD)) formula: 57 111 CKD 1-2, 78 stage 3, 23 4-5.The differed significantly respect to 1,5-AG fasting plasma glucose (FPG), age, duration diabetes,...
Introduction The aim of this study was to improve the quality diabetes control and evaluate efficacy an Internet-based integrated healthcare system for management safety. Methods We conducted a large-scale, multi-centre, randomized clinical trial involving 484 patients. Patients in intervention group ( n = 244) were treated with six months, while 240) received usual outpatient over same period. HbA1c, blood chemistries, anthropometric parameters, adverse events assessed at beginning study,...
Angiotensin-converting enzyme 2 (ACE2) plays an important role in glucose metabolism and renal function. However, the relationship between ACE2 hyperglycemia or microalbuminuria has not been established humans. We investigated whether urinary levels are associated with abnormal homeostasis albumin excretion.We developed ELISA for quantifying urine. The was used to measure 621 subjects with: normal tolerance (NGT; n=77); impaired fasting (IFG) (IGT) (n=132); type diabetes mellitus (T2DM,...
To evaluate the prevalence of and risk factors for diabetic retinopathy (DR) in Koreans with type II diabetes.Subjects (400 male, 296 female) aged 30-65 years (mean 55.3 years) hyperglycaemia (fasting plasma glucose ≥7.0 mmol/ml) or known diabetes (mean±SD duration 6.36±5.73 were enrolled Seoul Metro-City Diabetes Prevention Program (SMC-DPP) from September 2008 to 2009. The severity DR was diagnosed by grading fundus photographs taken five standard fields per eye categorised following Early...
This study aims to investigate the discrepancy between clinicians' perceptions and actual achievement rates of low density lipoprotein cholesterol (LDL-C) in Korean patients with diabetes according updated American Diabetes Association (ADA)/American College Cardiology Foundation (ACC) recommendations.This is a multi-center, retrospective, non-interventional, observational study. Diabetic aged 18 years or older were eligible if they had been diagnosed hypercholesterolemia receiving...
Background Sirtuin (Sirt), a sensor of the cell metabolic state, regulates glucose and lipid metabolism. The aim this study was to address whether rosiglitazone (RGZ) alters hepatic Sirt1 and/or Sirt6 have regulatory role in protective effects RGZ on hepatocyte steatosis. Methods To investigate effect Sirt1, rats were administered with for 6 weeks. involvement Sirt1/6 RGZ-mediated against steatosis evaluated by single or double knockdown model. Results vivo increased expression its activity...
Customarily used classification of IPF did not satisfy a sizable group patients with that in the past had been lumped UIP and now currently has begun to be recognized as nonspecific interstitial pneumonia/fibrosis (NIP). There are few reports about clinical features NIP.The pathologic slides 66 having open lung biopsy (OLB) for differential diagnosis diseases (ILD) from 1984 1995 were reviewed. Seven cases confirmed NIP. The record, pulmonary function tests (PFT), chest PA HRCT reviewed...
Adiponectin and tumor necrosis factor‑α (TNF‑α) exert opposite effects on obesity‑associated inflammation insulin signaling. The purpose of the present study was to investigate chronic TNF‑α adiponectin levels in 3T3‑L1 adipocytes, as well potential reversal mechanisms. Differentiated adipocytes were exposed for three different incubation times then various wash‑off periods with or without mitogen‑activated protein kinase (MAPK) inhibitors. significantly reduced gene expression a dose‑...
Combination of metformin to reduce the fasting plasma glucose level and an α-glucosidase inhibitor decrease postprandial is expected generate a complementary effect. We compared efficacy safety fixed-dose combination voglibose plus (vogmet) with monotherapy in drug-naïve newly-diagnosed type 2 diabetes mellitus.A total 187 eligible patients aged 20 70 years, glycosylated hemoglobin (HbA1c) 7.0% 11.0%, were randomized into either vogmet or treatments for 24 weeks. A change HbA1c from baseline...
The purpose of this study was to determine the appropriate exercise intensity associated with maximum fat oxidation, improvement body composition, and metabolic status in Korean women type 2 diabetes mellitus (T2DM).The included a T2DM group (12 women) control women). groups were matched age mass index. subjects performed graded test on cycle ergometer measure their maximal oxidation (Fatmax). We also measured profiles, mitochondrial DNA (mtDNA).The for Fatmax significantly lower (34.19%...
Aims To compare the commonly prescribed oral anti-diabetic drug (OAD) combinations to use as an add-on therapy with insulin glargine in patients uncontrolled type 2 diabetes despite submaximal doses of OADs. Methods People inadequately controlled (n = 99) were randomly assigned on a 1∶1∶1 basis receive glargin, fixed glimepiride, metformin, and glimepiride plus metformin. Outcomes assessed included HbA1c, changes fasting glucose levels, body weight, serum lipids values, dose symptomatic...
The Modality of Insulin Treatment Evaluation (MOTIV) study was performed to provide real-world data concerning insulin initiation in Korean type 2 diabetes mellitus (T2DM) patients with inadequate glycemic control oral hypoglycemic agents (OHAs).This multicenter, non-interventional, prospective, observational enrolled T2DM (glycosylated hemoglobin [HbA1c] ≥7.0%) who had been on OHAs for ≥3 months and were already decided introduce basal by their physician prior the start study. All treatment...
The aim of this study was to compare the fasting serum glucose level with plasma for diagnosing hyperglycemic states in real-life clinical situations. Additionally, we investigated a usual delay sample processing and how such delays can impact diagnosis states. Among 1,254 participants who had normoglycemia or impaired (IFG) assessed by level, 20.9% were newly diagnosed diabetes based on level. Of normoglycemia, 62.1% 14.2% IFG diabetes, respectively, according In our laboratory performing...
Recent studies have shown the importance of postprandial glucose (PPG) in development diabetes complications. This study was conducted order to survey perceptions clinicians and diabetic patients with respect PPG management current status education.This a cross-sectional involving face-to-face interviews an open questionnaire Korea. A total 300 130 completed questionnaires, which included education status, self monitoring blood (SMBG), criteria diagnosis management, relating management.While...
Background: We compared the prevalences of two criteria metabolic syndrome, that is, American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI) International Diabetes Federation (IDF), in Korean male adults predictability insulin resistance future cardiovascular diseases using Framingham Risk Score. Methods: In total 23,467 (mean age 43.3 years) who participated medical check-up 2005, syndrome according to AHA/NHLBI ID F presence resistance, defined by highest quartile...