A5014689286- Lipoproteins and Cardiovascular Health
- Cardiovascular Disease and Adiposity
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Function and Risk Factors
- Liver Disease Diagnosis and Treatment
- Blood Pressure and Hypertension Studies
- Cancer, Lipids, and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Smoking Behavior and Cessation
- Cardiovascular Health and Disease Prevention
- Insect and Arachnid Ecology and Behavior
- Cardiac Imaging and Diagnostics
- Heart Rate Variability and Autonomic Control
- Retinal Development and Disorders
- Diverse Approaches in Healthcare and Education Studies
- Spacecraft Design and Technology
- Nutrition and Health in Aging
- Alcohol Consumption and Health Effects
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Ecology and Conservation Studies
- Nutrition, Health and Food Behavior
- Plant and animal studies
- Chronic Kidney Disease and Diabetes
- Cardiovascular Health and Risk Factors
- Atrial Fibrillation Management and Outcomes
Kangbuk Samsung Hospital
2016-2025
Sungkyunkwan University
2016-2025
California State University, Fresno
2024
St George’s University Hospitals NHS Foundation Trust
2023
Johns Hopkins University
2015-2022
Uijeongbu St. Mary's Hospital
2021-2022
Catholic University of Korea
2021-2022
Samsung (South Korea)
2021
Seoul National University Hospital
2011-2018
Yonsei University
2000-2018
Associations between hyperuricemia, cardiovascular diseases and diabetes have been reported, but few of the studies conducted in Korean population. The present study examined a adult population with respect to relationships serum uric acid concentrations hypertension, insulin resistance, risk factors metabolic syndrome.A total 53,477 subjects were divided into 4 groups according quartiles. incidence hypertension all was higher first quartile than third plus fourth (odds ratio (OR) 1.192, p <...
Abstract Retinal ischemia/reperfusion (I/R) injury is an important cause of visual impairment. However, questions remain on the overall I/R mechanisms responsible for progressive damage to retina. In this study, we used a mouse model and characterized pathogenesis by analyzing temporal changes retinal morphology function associated with in gene expression. Transient ischemia was induced one eye C57BL/6 mice raising intraocular pressure 120 mmHg 60 min followed reperfusion restoring normal...
Adipocyte fatty acid-binding protein (A-FABP), also known as aP2 or FABP4, is abundantly expressed in adipocytes and plays a role glucose homeostasis. We analyzed the relationship between coronary artery disease serum FABP4 levels Korean adults.In total of 234 adults, whom angiograms were performed, anthropometric measurements done fasting lipid profiles measured. Serum measured using ELISA. The presence metabolic syndrome was diagnosed according to American Heart Association/National Heart,...
The c-Jun N-terminal kinase (JNK) signaling pathway plays an important role in neuronal pathophysiology. Using JNK inhibitors, we examined involvement of the cultured rat retinal ganglion cell (RGC) death and mouse ischemia/reperfusion (I/R) injury visual axis. vitro effects inhibitors were evaluated adult cells enriched RGCs. Retinal I/R was induced C57BL/6J mice through elevation intraocular pressure to 120 mmHg for 60 min followed by reperfusion. SP600125 administered intraperitoneally...
Because of a huge amount Zn2+ in secretory granules pancreatic islet beta-cells, released certain conditions might affect the function or survival cells. We studied potential paracrine effects endogenous on beta-cell death. induced insulinoma/islet cell death dose-dependent manner. Chelation by CaEDTA significantly decreased streptozotocin (STZ)-induced an vitro culture system simulating vivo circumstances but not conventional system. chelation continuous infusion incidence diabetes after...
OPG (osteoprotegerin) is an inhibitor of osteoclastogenesis and recent work suggests it has a role in atherosclerosis. Therefore we measured serum levels patients with coronary artery disease, compared the among different groups according to number stenotic vessels determined whether there was any correlation aortic calcification, LV (left ventricular) mass index CRP (C-reactive protein) levels. Subjects (n=100; mean age, 57 years) who underwent angiograms were enrolled. Blood pressure, body...
We investigated the incidence of metabolic syndrome and assessed effect smoking status weight change on incident syndrome.This study included 4,542 men without at baseline who were followed for an average 3 years. Subjects divided into four categories according to 3-year follow-up.The overall was 10.6%: 8.0% in nonsmokers, 7.1% new smokers, 17.1% ex-smokers, 13.9% sustained smokers (P < 0.001). In a multivariate regression model, ex-smokers had significantly increased odds with mean 1.45...
<b><i>Objectives:</i></b> To assess the relationship between nonalcoholic fatty liver disease (NAFLD) and arterial stiffness in nondiabetic, nonhypertensive individuals with without metabolic syndrome (MetS). <b><i>Methods:</i></b> Hepatic ultrasound brachial-ankle pulse wave velocity (baPWV) were investigated 4,467 individuals. The subjects classified into normal PWV increased (≥1,366 cm/s) groups, divided 2 groups (non-NAFLD vs. NAFLD groups)...
Background The ECG is a simple, noninvasive screening method for cardiovascular disease and arrhythmia. impact of abnormality on mortality not certain in low‐risk populations. To address this, we evaluated the association between mortality. Methods Results We retrospectively assessed baseline all‐cause 660 383 patients presenting medical check‐ups. Baseline abnormalities were classified according to Minnesota Code. Among total participants, 23 609 (3.6%) had major 110 038 (16.7%) minor...
Coronary artery spasm is not infrequently seen in Korea. Most of the patients with coronary show a focal angiography. However, cause disease well known. There have been few anecdotal case reports associated hyperthyroidism, but there has report concerning large series such patients. Over period 5 years and 8 months, we experienced eight having diffuse or severe type association hyperthyroidism.We investigated characteristics spasm, which was diagnosed by angiography provocation an...
This study assessed the effect on incident metabolic syndrome (MetS) of alcohol consumption status at baseline and changes in that during a follow-up period. 4,505 men without MetS were followed for an average 3 years. Subjects divided into 4 categories The overall incidence was 10.6%: 7.0% non-drinkers, 10.3% light drinkers, 13.8% moderate 15.6% heavy drinkers (P<0.001). All drinker groups had higher odds ratios than non-drinkers (OR [95% confidence interval]: 1.51 [1.06-2.13] 1.71...
Few studies have investigated the association between coronary artery calcium (CAC) progression and arterial stiffness measured by brachial-ankle pulse wave velocity (baPWV). We examined influence of severity baseline baPWV on CAC in a large prospective cohort.A total 1600 subjects who voluntarily participated comprehensive health-screening program March 2010 December 2013 had as well serial follow-up computed tomography performed approximately 2.7 ± 0.5 years apart were enrolled study.A...
Purpose: Previous studies showed inconsistent results concerning the relationship between chronic smoking and blood pressure. Most of involved self-reported status. This study was performed to evaluate association urinary cotinine or status with hypertension pressure in Korean adults.Materials methods: Among individuals enrolled Kangbuk Samsung Health Study Cohort Study, 167,868 participants (men, 55.7%; age, 37.5 ± 6.9 years) 2011 2013 who had measurements were included. Individuals levels...