A5063141275- 3D IC and TSV technologies
- Electronic Packaging and Soldering Technologies
- Head and Neck Cancer Studies
- Liver Disease Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Diabetes Management and Research
- Ear and Head Tumors
- Pancreatic function and diabetes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Reproductive Biology and Fertility
- Veterinary Oncology Research
- Salivary Gland Tumors Diagnosis and Treatment
- Diabetes Treatment and Management
- Integrated Circuits and Semiconductor Failure Analysis
- Thyroid Disorders and Treatments
- Seismic Performance and Analysis
- Bone Metabolism and Diseases
- Cancer Diagnosis and Treatment
- Asthma and respiratory diseases
- Phytoestrogen effects and research
- Metabolism, Diabetes, and Cancer
- Bone health and treatments
- Animal Genetics and Reproduction
- Diabetes and associated disorders
- Pituitary Gland Disorders and Treatments
Chungnam National University
2015-2024
Yonsei University
2023-2024
Catholic University of Korea
2007-2024
Pusan National University
2002-2024
Yonsei University Health System
2016-2024
Korea Research Institute of Bioscience and Biotechnology
2014-2024
SK Group (South Korea)
2013-2024
Yeouido St. Mary's Hospital
2024
Samsung (South Korea)
2022
Kyung Hee University
2018-2022
In the presence of obesity, β-cell mass needs to be increased compensate for accompanying demands and maintain euglycemia. However, in Korea, majority type 2 diabetic patients are nonobese. We determined absolute masses, relative volumes, ratio α- pancreas islets normal Korean subjects correlate these findings with clinical characteristics. Whole pancreases procured from organ donors were divided into 24 parts (control 1, n = 9). Tissue was also obtained by surgical resection after 35...
HBM (High Bandwidth Memory) is an emerging standard DRAM solution that can achieve breakthrough bandwidth of higher than 256GBps while reducing the power consumption as well. It has stacked architecture with core dies on top a base logic die, based TSV and die stacking technologies. In this paper, introduced comparison its generations provided. Also, packaging technology challenges to address reliability, thermal dissipation capability, maximum allowable package sizes, high throughput...
Impaired macroautophagy/autophagy has been implicated in experimental and human nonalcoholic steatohepatitis (NASH). However, the mechanism underlying autophagy dysregulation NASH is largely unknown. Here, we investigated role of TXNIP/VDUP1 (thioredoxin interacting protein), a key mediator cellular stress responses, pathogenesis NASH. Hepatic TXNIP expression was upregulated fatty liver disease (NAFLD) patients methionine choline-deficient (MCD) diet-fed mice, as well palmitic acid...
The association between autoimmune thyroiditis (AIT) and thyroid cancer is still not clear despite many previous reports. This study investigated whether serologic antibodies are predictive of in patients with nodules.We retrospectively reviewed records nodules evaluated by ultrasonography-guided fine-needle aspiration cytology at our institution January 2006 December 2008. Thyroid autoimmunity was assessed measuring thyroglobulin antibody (TgAb) peroxidase (TPOAb). final outcome deciding a...
Through-silicon via is a critical element for three-dimensional (3D) integration of devices in multilevel stack structures. Thermally induced stresses through-silicon vias (TSVs) have raised serious concerns over mechanical and electrical reliability 3D technology. An experimental technique presented to characterize thermal TSVs during cycling based on curvature measurements bending beam specimens. Focused ion electron backscattering diffraction analyses reveal significant grain growth...
Abstract The reported mortality (40%) and neurologic morbidity (25%) rates for carotid rupture remain unacceptably high. This study was conducted to assess the impact of endovascular detachable balloon occlusion changing characteristics in head neck surgery. Between January 1, 1988, June 30, 1994, 18 ruptures were identified 15 patients. Etiologic factors included radical surgery, radiation therapy, wound complications, recurrent or persistent carcinoma. In instances rupture, patients...
PURPOSE Two consecutive randomized trials were run at our institution using the bioreductive alkylating agent mitomycin as an adjunct to radiation therapy in effort improve outcome patients with squamous cell carcinoma of head and neck. METHODS Between 1980 1992, two (trial 1) dicumarol 2) neck conducted institution. The stratified by intent therapy, extent disease, primary tumor site. Within each strata, receive or without mitomycin/dicumarol 2). RESULTS A total 203 enrolled onto both...
Oral cavity and oropharyngeal cancer in younger adults is a rare entity with an incidence of 2.7% among 1014 patients seen or treated at the Department Therapeutic Radiology, Yale-New Haven Medical Center between 1958 1980. Although there are reports contrastingly divergent therapeutic experiences, authors contend that even early stage cancers frequently fail definitive therapy rampant course, causing rapidly fatal outcome. The three-year actuarial survival was mere 17% Yale. speculate adult...
To examine the association of serum vitamin D level with metabolic syndrome (MetS) and hypertension (HTN) in middle-aged Korean subjects.We conducted a population-based, cross-sectional survey 1330 participants aged over 40 years (median age 65.8 years) Chungju, Korea, 2007. The 324 subjects, who were normotensive 2003 attended follow-up visit 4 later, included an analysis risk HTN.Serum 25-hydroxy-vitamin [25(OH)D] PTH measured central laboratory, using chemiluminescence assays.The overall...
Three-dimensional integration with through-silicon vias (TSVs) has emerged as an effective solution to overcome the wiring limit imposed on device density and performance. However, thermal stresses induced in TSV structures raise serious thermomechanical reliability concerns. In this paper, we analyze near-surface stress distribution a structure based semi-analytic approach finite element method, comparison micro-Raman measurements. particular, depth dependence of effect elastic anisotropy...
Since insulin resistance can lead to hyperglycemia, improving glucose uptake into target tissues is critical for regulating blood levels. Among the free fatty acid receptor (FFAR) family of G protein-coupled receptors, GPR41 known be Gαi/o-coupled short-chain acids (SCFAs) such as propionic (C3) and valeric (C5). This study aimed investigate role in modulating basal insulin-stimulated insulin-sensitive cells including adipocytes skeletal muscle cells. Expression mRNA protein was increased...
Statins have been postulated to affect the bone metabolism. Recent experimental and epidemiologic studies suggested that statins may also protective effects. This study assessed effects of simvastatin on proliferation differentiation human marrow stromal cells (BMSCs) in an ex vivo culture. The was obtained from healthy donors. Mononuclear were isolated cultured osteoblastic lineage. In primary culture, 10(-6) M diminished mean size colony forming units-fibroblastic (CFU-Fs) enhanced matrix...
The poor functional outcome in patients with advanced head and neck squamous cell carcinoma (HNSCC) surgery radiation has led to alternative approaches disease. We conducted a phase II study of induction chemotherapy followed by concurrent chemoradiotherapy for organ preservation resectable unresectable (nasopharyngeal) tumors.Forty-two stage III IV HNSCC nasopharyngeal tumors received two courses cisplatin (20 mg/m2/d continuous infusion [CI]), fluorouracil (800 CI), leucovorin (500 CI;...
Copper is a vital trace element required for normal growth and development of many organisms. To determine the roles copper transporter 1 (Ctr1) in hepatic metabolism contribution liver to systemic homeostasis, we have generated characterized mice which Ctr1 deleted specifically liver. These express less than 10% residual protein exhibit small but significant retardation, disappears with age. Hepatic concentrations activities copper-requiring enzymes are reduced; however, mild deficiency...