A5089329487- Bone Metabolism and Diseases
- Bone health and treatments
- Periodontal Regeneration and Treatments
- dental development and anomalies
- NF-κB Signaling Pathways
- Dental Implant Techniques and Outcomes
- Oral and Maxillofacial Pathology
- Bone and Dental Protein Studies
- Bone Tissue Engineering Materials
- Trace Elements in Health
- Mesenchymal stem cell research
- Cancer-related gene regulation
- TGF-β signaling in diseases
- Cleft Lip and Palate Research
- Cytokine Signaling Pathways and Interactions
- MicroRNA in disease regulation
- Bone fractures and treatments
- Bone health and osteoporosis research
- Cancer Cells and Metastasis
- Craniofacial Disorders and Treatments
- Bone Tumor Diagnosis and Treatments
- Oral and gingival health research
- Oral microbiology and periodontitis research
- Orthopaedic implants and arthroplasty
- Electrospun Nanofibers in Biomedical Applications
Kyungpook National University
2014-2023
Regenerative Medicine Institute
2017
Kyungpook National University Hospital
2003-2010
Daegu University
2009
Massachusetts General Hospital
2003
Harvard University
2003
Zinc is an essential trace element required for bone formation, however not much has been clarified yet its role in osteoblast. We hypothesized that zinc would increase osteogenetic function osteoblasts. To test this, we investigated whether treatment enhances formation by stimulating osteoblast proliferation, marker protein alkaline phosphatase activity and collagen synthesis osteoblastic MC3T3-E1 cells. cells were cultured treated with various concentrations of (0, 1, 3, 15, 25 uM) along a...
Bisphosphonate-related jaw necrosis (BRONJ) associated with dental implants is a rare but continuously reported complication. To verify clinical and pathological characteristics of BRONJ around implants, the present study analyzed clinical, radiographic histopathological findings these lesions.Nineteen patients were diagnosed osteonecrosis treated at our institute from 2008 to 2011. The patients' medical history, demographic features, radiographic, along information on bisphosphonates (BP)...
Extracellular matrix proteins have been implicated in the regulation of osteoblast differentiation bone marrow derived mesenchymal stem cells (BMSCs) through paracrine or autocrine mechanisms. In current study, we analyzed secretory protein profiles BMSCs grown osteogenic medium (OSM) and identified SPARC-related modular calcium-binding 1 (SMOC1), a member SPARC family, as regulator BMSCs. with high low potential were grouped stimulated OSM, after which conditioned was collected by LC-MS/MS....
Purpose: Various sinus augmentation procedures, using bone substitutes, have been used to place dental implants in the atrophic posterior maxilla. The aim of this article is evaluate possibility new formation maxillary without a graft. Materials: Ten patients significant pathosis were selected for study. bony window was prepared lateral wall ultrasonic piezoelectric surgery device (Surgybone, Silfradent srl, Sofia, Italy). membrane elevated superiorly and placed simultaneously maintain space...
Regulation of the formation and function bone-resorbing osteoclasts (OCs) is a key to understanding pathogenesis skeletal disorders. Gene-targeting studies have shown that RANK signaling pathway plays critical role in OC differentiation function. Although pharmaceutical blockade may be viable strategy for preventing bone destruction, implicated multiple biological processes. Recently, cytoplasmic motif was identified specifically involved differentiation. Here, we developed cell-permeable...
Abstract The epidermal growth factor receptor (EGFR) functions in various cellular physiological processes such as proliferation, differentiation, and motility. Although recent studies have reported that EGFR signaling is involved osteoclast recruitment formation, the molecular mechanism of for regulation osteoclastogenesis remains unclear. We investigated role differentiation survival show expression was highly up‐regulated by activator nuclear factor‐κB ligand (RANKL) during...
The human tooth is the hardest organ of body, and composed enamel, dentin, dental pulp. Dentin provides basis shape by lining inner parts root crown. Odontoblasts deposit an organic matrix that contains collagen, noncollagenous proteins, phospholipids, growth factors. In this study, we sought to reveal proteins in dentin using liquid chromatography−tandem mass spectroscopy (LC-MS/MS) proteomic approaches. Human third molar dentins were cut, isolated, demineralized, extracted separated on...
While the soluble proteins of human teeth consist various extracellular matrix and bioactive proteins, they have not yet been characterized fully. Moreover, role play in tooth regeneration is clear. Analysis by liquid chromatography-mass spectrometry revealed 147 different ethylenediaminetetraacetic acid-soluble (ESTPs). Of these, 29 had shown previously to be present teeth. To determine their effect on vitro responses dental pulp stem cells (DPSCs), DPSCs were cultured ESTP-coated culture...
Previous linkage analysis of an Asian population proposed possible candidate genes for mandibular prognathism, such as Matrilin-1 (cartilage matrix protein). To investigate the association between single-nucleotide polymorphisms (SNPs) in and we investigated three sequence variants (-158 T>C, 7987 G>A, 8572 C>T) 164 prognathism patients 132 control individuals with a normal occlusion. The results showed that TT genotypes increased risk (OR = 9.28, 95% Cl 1.19~197.57, P < 0.05),...
Systemic transplantation of adipose-derived stem cells (ASCs) is emerging as a novel therapeutic option for functional recovery diverse damaged tissues. This study investigated the effects systemic human ASCs (hASCs) on bone repair. We found that hASCs secrete various cell-activating factors, including hepatocyte growth factor and extracellular matrix proteins. into ovariectomized mice induced an increased number both osteoblasts osteoclasts in tissue thereby prevented loss. also observed...
Excessive bone resorption by osteoclasts (OCs) can result in serious clinical outcomes, including loss that may weaken skeletal or periodontal strength. Proper homeostasis and strength are maintained balancing OC function with the bone-forming of osteoblasts. Unfortunately, current treatments broadly inhibit differentiation also interfere coupled formation. We therefore identified a factor, purinergic receptor P2X5 is highly expressed during maturation phase, which we show here plays no...
Osteoblasts not only control bone formation but also support osteoclast differentiation. Here we show the involvement of Kruppel-like factor 4 (KLF4) in differentiation osteoclasts and osteoblasts. KLF4 was down-regulated by 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) Overexpression osteoblasts attenuated 1,25(OH)2D3-induced co-culture mouse marrow cells through down-regulation receptor activator nuclear κB ligand (RANKL) expression. Direct binding to RANKL promoter repressed expression...
Osteogenesis and angiogenesis, including cell–cell communication between blood vessel cells bone cells, are essential for repair. Fucoidan is a chemical compound that has variety of biological activities. It stimulates osteoblast differentiation in human mesenchymal stem (MSCs), which turn induces angiogenesis. However, the mechanism by this osteoblasts endothelial mediated remains unclear. Thus, aim study was to clarify relationship fucoidan-induced osteoblastic MSCs angiogenesis cells....
Pathological bone loss is caused by an imbalance between formation and resorption. The microenvironments are hypoxic, hypoxia-inducible factor (HIF) known to play notable roles in remodeling. However, the relevant functions of HIF-2α not well understood. Here, we have shown that deficiency mice enhances mass through its effects on differentiation osteoblasts osteoclasts. In vitro analyses revealed inhibits osteoblast targeting Twist2 stimulates RANKL-induced osteoclastogenesis via regulation...
Ferroptosis is a distinct form of regulated cell death characterized by iron-dependent lipid peroxidation. The ferroptosis mechanism involves complex interactions between fatty acid metabolism, iron peroxidation, and antioxidative defense mechanisms. Fatty acids, especially polyunsaturated acids (PUFAs), are susceptible to leading the formation peroxides. Iron metabolism plays critical role, as excessive free catalyzes production reactive oxygen species (ROS) via Fenton reaction, further...
Abstract In the study, characterization of anodized titanium surface was performed. addition, histological evaluation and interfacial strength at bone–implant interface characterized surfaces were then evaluated with use a rabbit model 6 12 weeks after implantation. Surface treatments consisted either anodization or followed by hydrothermal treatments. Nontreated used as controls in this study. Using scanning‐electron microscopy, porous oxide layers observed on implants, whereas HA needles...
Zn is an essential nutrient that required in humans and animals for many physiological functions, including immune antioxidant function, growth, reproduction.The present study evaluated whether deficiency would negatively affect bone-related enzyme, ALP, other minerals (Ca, P Mg) rats.Thirty Sprague Dawley rats were assigned to one of the three different dietary groups, such as adequate (ZA, 35 mg/kg), pair fed (PF, deficient (ZD, 1 mg/kg) diet, 10 weeks.Food intake body weight measured...