A5016460560- Orthodontics and Dentofacial Orthopedics
- Dental Radiography and Imaging
- Dental Implant Techniques and Outcomes
- Temporomandibular Joint Disorders
- Craniofacial Disorders and Treatments
- Bone health and treatments
- Bone and Joint Diseases
- Cleft Lip and Palate Research
- Periodontal Regeneration and Treatments
- Cancer Diagnosis and Treatment
- dental development and anomalies
- Oral and Maxillofacial Pathology
- Facial Rejuvenation and Surgery Techniques
- Facial Trauma and Fracture Management
- Reconstructive Surgery and Microvascular Techniques
- Bone Tumor Diagnosis and Treatments
- Head and Neck Surgical Oncology
- Bone Tissue Engineering Materials
- Reconstructive Facial Surgery Techniques
- Facial Nerve Paralysis Treatment and Research
- Dental Education, Practice, Research
- Bone Metabolism and Diseases
- Nasal Surgery and Airway Studies
- Mesenchymal stem cell research
- Bone fractures and treatments
Kyungpook National University
2016-2025
China Railway Construction Corporation (China)
2021
University of Illinois Chicago
2020
Faculty of 1000 (United States)
2019
Chung-Ang University
2015
Kyungpook National University Hospital
2005-2013
University of Michigan
2010-2011
Osaka University
2000-2010
Keimyung University
2002-2010
University of Freiburg
2010
The ATLAS trial compared axitinib versus placebo in patients with locoregional renal cell carcinoma (RCC) at risk of recurrence after nephrectomy.In a phase III, randomized, double-blind trial, had >50% clear-cell RCC, undergone nephrectomy, and no evidence macroscopic residual or metastatic disease [independent review committee (IRC) confirmed]. intent-to-treat population included all randomized [≥pT2 and/or N+, any Fuhrman grade (FG), Eastern Cooperative Oncology Group status 0/1]....
Three cases are illustrated. One was treated with maxillary microscrew implants, another mandibular and the third both implants. With anterior teeth were retracted bodily a slight intrusion all premolar extraction space closed without loss of anchorage. Furthermore, posterior showed distal movement. The implants controlled vertical position played an important role in improving facial profile. efficacy sliding mechanics implant anchorage on treatment skeletal Class II malocclusion is also discussed.
Bisphosphonate-related jaw necrosis (BRONJ) associated with dental implants is a rare but continuously reported complication. To verify clinical and pathological characteristics of BRONJ around implants, the present study analyzed clinical, radiographic histopathological findings these lesions.Nineteen patients were diagnosed osteonecrosis treated at our institute from 2008 to 2011. The patients' medical history, demographic features, radiographic, along information on bisphosphonates (BP)...
The maxillary and mandibular posterior teeth were retracted with microscrew implants (1.2 mm in diameter six to 10 long) that placed into the alveolar bone used as anchorage. retraction proceeded without adverse reciprocal effects on reactive part of conventional mechanics, such premolar extrusion flaring incisors. anterior crowding was resolved any deleterious effect facial profile. En masse movement whole dentition after tooth alignment can reducethe treatment period maximize efficiency...
Angiogenesis and bone formation are intimately related processes. Hypoxia during early development stabilizes hypoxia-inducible factor-1α (HIF-1α) increases angiogenic signals including vascular endothelial growth factor (VEGF). Furthermore, stabilization of HIF-1α by genetic or chemical means stimulates formation. On the other hand, deficiency Runx2, a key osteogenic transcription factor, prevents invasion VEGF expression. This study explores possibility that Runx2 interact to activate...
Calvarial bone is formed by the intramembranous bone-forming process, which involves many signaling molecules. The constitutive activation of fibroblast growth factor (FGF) pathway accelerates osteoblast differentiation and results in premature cranial suture closure. Bone morphogenetic protein (BMP) pathways, involve downstream transcription factors Dlx5 Msx2, are also involved processes. However, relationships between these two main cascades still unclear. We found that FGF2 treatment...
The human tooth is the hardest organ of body, and composed enamel, dentin, dental pulp. Dentin provides basis shape by lining inner parts root crown. Odontoblasts deposit an organic matrix that contains collagen, noncollagenous proteins, phospholipids, growth factors. In this study, we sought to reveal proteins in dentin using liquid chromatography−tandem mass spectroscopy (LC-MS/MS) proteomic approaches. Human third molar dentins were cut, isolated, demineralized, extracted separated on...
Parathyroid hormone (PTH) is a potent anabolic agent for the treatment of osteoporosis. However, its mechanism action in osteoblast and bone not well understood. In this study, we show that actions PTH are severely impaired both growing adult ovariectomized mice lacking bone-related activating transcription factor 4 (ATF4). Our study demonstrates ATF4 deficiency suppresses PTH-stimulated proliferation survival abolishes PTH-induced differentiation, which, together, compromise response. We...
Previous linkage analysis of an Asian population proposed possible candidate genes for mandibular prognathism, such as Matrilin-1 (cartilage matrix protein). To investigate the association between single-nucleotide polymorphisms (SNPs) in and we investigated three sequence variants (-158 T>C, 7987 G>A, 8572 C>T) 164 prognathism patients 132 control individuals with a normal occlusion. The results showed that TT genotypes increased risk (OR = 9.28, 95% Cl 1.19~197.57, P < 0.05),...
The aim of this randomized single-blinded active-controlled clinical study was to evaluate the early efficacy low-dose Escherichia coli–derived recombinant human bone morphogenetic protein 2 (rhBMP-2) soaked with hydroxyapatite granules (BMP-2/H) as compared an inorganic bovine xenograft (ABX) in maxillary sinus floor augmentation. In a total 127 subjects who were enrolled at 6 centers, floors augmented 1 mg/mL rhBMP-2 (0.5 2.0 mg per sinus) and BMP-2/H g; n = 65) or ABX alone 62). Core...
We evaluated potential biomarkers in human whole saliva for the early diagnosis of oral squamous cell carcinoma (OSCC). selected 30 candidate genes with relevance to cancer from recent reports PubMed. Saliva samples were obtained 34 non-tumor control and 33 OSCC patients. Real-time PCR was performed, mRNA levels compared. Normalized six (NGFI-A binding protein 2 (NAB2), cytochrome P450, family 27, subfamily A, polypeptide 1 (CYP27A1), nuclear pore complex interacting family, member B4...
Abstract It is still challenging to predict the efficacy of cisplatin-based therapy, particularly in relation activation macroautophagy/autophagy oral squamous cell carcinoma (OSCC). We studied effect selected chromatin remodeling genes on cisplatin resistance and their interplay with autophagy 3-dimensional tumor model xenografts. analyzed gene expression patterns cisplatin-sensitive UMSCC1, a paired cisplatin-resistant UM-Cis cells. Many histone protein clusters involved nucleosome...
The potential of large language models (LLMs) in medical applications is significant, and Retrieval-augmented generation (RAG) can address the weaknesses these terms data transparency scientific accuracy by incorporating current knowledge into responses. In this study, RAG GPT-4 OpenAI were applied to develop GuideGPT, a context aware chatbot integrated with database from 449 publications designed provide answers on prevention, diagnosis, treatment medication-related osteonecrosis jaw...