A5058558749- Orthodontics and Dentofacial Orthopedics
- Bone Tissue Engineering Materials
- Temporomandibular Joint Disorders
- Periodontal Regeneration and Treatments
- Craniofacial Disorders and Treatments
- Dental Radiography and Imaging
- Dental Implant Techniques and Outcomes
- Facial Trauma and Fracture Management
- Bone Metabolism and Diseases
- Planarian Biology and Electrostimulation
- Cleft Lip and Palate Research
- Proteoglycans and glycosaminoglycans research
- Bone health and treatments
- Mesenchymal stem cell research
- Neuroscience and Neural Engineering
- Anatomy and Medical Technology
- Bone fractures and treatments
- Osteoarthritis Treatment and Mechanisms
- Hydrogels: synthesis, properties, applications
- Bone health and osteoporosis research
- 3D Printing in Biomedical Research
- Nerve injury and regeneration
- Facial Rejuvenation and Surgery Techniques
- Advancements in Semiconductor Devices and Circuit Design
- Semiconductor materials and devices
Seoul National University Dental Hospital
2014-2023
Jungheinrich (Germany)
2020
Seoul National University
2010-2019
Sion College
2019
Jeonbuk National University
2019
Chonnam National University Hospital
2016
Ministry of Health and Welfare
2016
Seoul National University of Science and Technology
2012
Korea University
2010
Samsung (South Korea)
2005-2009
Electrical stimulation (ES) can activate diverse biostimulatory responses in a range of tissues. Of various forms ES, the application biphasic electric current (BEC) is new approach to bone formation. This study investigate effects and mechanism action BEC osteoblast differentiation cytokine production human mesenchymal stromal cells (hMSCs). Using an vitro culture system with modified version stimulator chip used our previous study, we exposed hMSCs 100 Hz ES magnitude 1.5/15 μA/cm2 for...
Abstract Hyaluronic acid is a natural glycosaminoglycan involved in biological processes. Low‐molecular‐weight hyaluronic (10 and 50 kDa)‐based hydrogel was synthesized using derivatized acid. acrylated by two steps: (1) introduction of an amine group adipic dihydrazide, (2) acrylation N ‐acryloxysuccinimide. Injectable acid‐based prepared poly(ethylene glycol) tetra‐thiols via Michael‐type addition reaction. Mechanical properties the were evaluated varying molecular weight kDa) percent...
Low-magnitude high-frequency (LMHF) vibrations have the ability to stimulate bone formation and reduce loss. However, anabolic mechanisms that are mediated by vibration in human cells at cellular level remain unclear. We hypothesized mesenchymal stromal (hMSCs) display direct osteoblastic responses LMHF signals. Daily exposure increased proliferation of hMSCs, with highest efficiency occurring a peak acceleration 0.3 g 30 40 Hz. Specifically, these conditions promoted osteoblast...
Abstract Hyaluronic acid (170 kDa)‐based hydrogel was synthesized using acrylated hyaluronic (HA) and matrix metalloproteinase (MMP) sensitive HA‐based hydrogels were then prepared by conjugation with two different peptides: cell adhesion peptides containing integrin‐binding domains (Arg‐Gly‐Asp: RGD) a cross‐linker MMP degradable to mimic the remodeling characteristics of natural extracellular matrices cell‐derived MMPs. Mechanical properties these evaluated weight percentages (2.5 3.5 wt...
Clinical data show that estrogen levels are inversely associated with the production of sclerostin, a Wnt antagonist recently attracted great attention over use its antibody in anabolic treatment osteoporotic conditions. However, molecular link between sclerostin expression and signaling is not yet known. We investigated mechanisms by which modulates (SOST) gene at cellular level human osteoblast cells association bone morphogenetic protein (BMP)2 given BMP2 potential inducer SOST...
The aim of this randomized single-blinded active-controlled clinical study was to evaluate the early efficacy low-dose Escherichia coli–derived recombinant human bone morphogenetic protein 2 (rhBMP-2) soaked with hydroxyapatite granules (BMP-2/H) as compared an inorganic bovine xenograft (ABX) in maxillary sinus floor augmentation. In a total 127 subjects who were enrolled at 6 centers, floors augmented 1 mg/mL rhBMP-2 (0.5 2.0 mg per sinus) and BMP-2/H g; n = 65) or ABX alone 62). Core...
A number of factors must be added to human bone marrow stromal cells (hBMSCs) in vitro induce osteogenesis, including ascorbic acid (AA), β ‐glycerophosphate (GP), and dexamethasone (Dex). Bone morphogenic protein (BMP)‐2 is an osteoinductive factor that can commit differentiate into osteoblasts. However, it still not clear whether the addition BMP‐2 alone hBMSCs complete osteoblast differentiation, resulting matrix mineralization. This study compares effects Dex, combined, on early late...
Nonglycosylated recombinant human bone morphogenetic protein (rhBMP)-2 prepared in Escherichia coli (E. rhBMP-2) has recently been considered as an alternative to mammalian cell rhBMP-2. However, its clinical use is still limited owing lack of evidence for osteogenic activity comparable with that rhBMP-2 via microcomputed tomography-based analysis. Therefore, this study aimed evaluate the ability E. absorbable collagen sponge form ectopic and orthotopic compare it In vitro investigation was...
High-frequency, low-magnitude accelerations can be anabolic and anticatabolic to bone. We tested the hypothesis that application of these mechanical signals accelerate bone regeneration in scaffolded nonscaffolded calvarial defects. The cranium experimental rats (n = 8) which 5-mm bilateral defects either contained a collagen scaffold or were left empty received oscillatory (45 Hz, 0.4 g) for 20 minutes per day 3 weeks. Compared with untreated control group 6), subject had 265% greater...
Abstract In vivo bone regeneration of chitosan–poly(ethylene oxide) (PEO) hydrogel in rat carlvarial defects was evaluated by using both human marrow‐derived stromal cells (hMSCs) and recombinant marrow protein‐2 (rhBMP‐2) for 4 8 weeks. situ chitosan–PEO fabricated mixing the precursor solutions chitosan‐acrylate PEO‐thiol. Fabrication injectable hydrogels modulated from within a minute to hours controlling temperature pHs solution. Gel swellings were dependent on conditions temperatures...