A5066917743- Obesity, Physical Activity, Diet
- Nutritional Studies and Diet
- Birth, Development, and Health
- Digital Radiography and Breast Imaging
- Global Cancer Incidence and Screening
- Health and Wellbeing Research
- Genetic Associations and Epidemiology
- Cancer survivorship and care
- Glaucoma and retinal disorders
- AI in cancer detection
- Health disparities and outcomes
- Cancer Risks and Factors
- Nutrition and Health in Aging
- Gut microbiota and health
- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Bone health and osteoporosis research
- Childhood Cancer Survivors' Quality of Life
- Cardiovascular Disease and Adiposity
- Eating Disorders and Behaviors
- Family Support in Illness
- Cardiovascular Health and Disease Prevention
- Diet and metabolism studies
- Blood Pressure and Hypertension Studies
Sungkyunkwan University
2015-2024
Samsung Medical Center
2015-2024
Samsung (South Korea)
2020-2022
The University of Melbourne
2020
Seoul National University Hospital
2019
Kangbuk Samsung Hospital
2010-2019
GTx (United States)
2015-2017
Day Family Medicine
2017
Inje University Busan Paik Hospital
2014
Seoul National University
2005-2012
<h3>Objective</h3> Metabolic syndrome (MetS) arises from complex interactions between host genetic and environmental factors. Although it is now widely accepted that the gut microbiota plays a crucial role in metabolism, current knowledge on effect of genetics specific microbes related to MetS status remains limited. Here, we investigated links among factors, humans. <h3>Design</h3> We characterised microbial community composition 655 monozygotic (n=306) dizygotic (n=74) twins their families...
Human papillomavirus (HPV) is the most important causative agent of cervical cancers worldwide. However, our understanding how vaginal microbiota might be associated with HPV infection limited. In addition, influence human genetic and physiological factors on unclear. Studies twins their families provide ideal settings to investigate complicated nature microbiota. This study investigated 68 HPV-infected or uninfected female using 454-pyrosequencing analysis targeting variable region (V2–V3)...
Obesity and type 2 diabetes (T2D) are linked both with host genetics environmental factors, including dysbioses of the gut microbiota. However, it is unclear whether these microbial changes precede disease onset. Twin cohorts present a unique genetically-controlled opportunity to study relationships between lifestyle factors microbiome. In particular, we hypothesized that family-independent in composition metabolic function during sub-clinical state T2D could be either causal or early...
Background and Purpose— The association between obesity stroke remains controversial, with earlier studies suggesting that differences might stem from heterogeneous subtype compositions. body mass index (BMI) subtypes was examined prospectively in a large cohort study. Methods— A total of 234 863 Korean men aged 40 to 64 years without substantial weight loss over 4 after baseline examination 1986 were divided into 8 categories BMI followed up 1991 2000 for fatal nonfatal events. Results—...
To examine the relation of adult height with mortality, authors conducted a cohort study 386,627 middle-aged South Korean male civil servants from 1992 to 1998. An inverse association between and all-cause mortality (14,003 deaths) was observed after adjustment for socioeconomic position major behavioral risk factors. The adjusted relative associated 5-cm increment in 0.97 (95% confidence interval: 0.95, 0.98). There little evidence associations coronary heart disease or overall cancer...
<h3>Abstract</h3> <b>Objective</b> To investigate risk factors, such as heavy alcohol consumption, that might explain any increased of haemorrhagic stroke associated with low blood cholesterol. <b>Design</b> Prospective cohort study. <b>Setting</b> Korea. <b>Participants</b> 787 442 civil servants (661 700 men, 125 742 women) aged 30-64. <b>Main outcome measures</b> Cardiovascular factors were assessed at biennial health check. Data on morbidity and mortality ascertained from 1990 to 2001...
Studies on the human gut microbiota have suggested that individuals could be categorized into enterotypes based compositions of their microbial communities. Here, we report healthy Koreans are clustered two enterotypes, dominated by either Bacteroides (enterotype 1) or Prevotella 2). More than 72% paired fecal samples from monozygotic twin pairs were assigned to same enterotype. Our longitudinal analysis these twins indicated more 80% belonged enterotype after about a 2-year interval....
Although hemorrhoids are one of the most common anal diseases among Koreans, risk factors for have not been well identified.We analyzed data from 4th Korean National Health and Nutrition Examination Survey (KNHANES) between 2007 2009. Study subjects were 17,228 participants KNHANES who aged 19 years or older. Logistic regression analysis was conducted to evaluate associations probable factors.Overall prevalence study 14.4%, being more prevalent women (15.7%) than men (13.0%). Obesity...
"Healthy Twin" is a twin family study extension of the existing Korean Twin-Family Register. Healthy Twin recruits adult like-sex twins over age 30 and their members. protocols are primarily tailored to quantitative trait loci complex traits as well role environment in etiology diseases. A full-length survey underway, including questionnaires, health examinations collection biological specimens. So far, 820 individuals (169 pairs families) have participated 1068 individual (608 pairs)...
To evaluate an association between obesity, measured by body mass index (BMI; kg/m(2)), and risk of cancer at individual all sites in postmenopausal women.A cohort 170,481 Korean women who were age 40 to 64 years baseline measurement BMI was observed prospectively from 1994 2003 for incidence. Multivariable adjusted proportional hazard models used evaluating the association.Women with a 30 kg/m(2) or higher had 23% than 21.0 22.9 (hazard ratio = 1.23; 95% CI, 1.08 1.41). According increase...
To evaluate the association between height and risk of cancer in an East Asian, middle-income population, authors followed up a cohort 788,789 Koreans (449,214 men 339,575 women) aged 40–64 years for incidence 1994 2003. Cox proportional hazards regression analysis was used to association. Each 5-cm increment associated with 5% 7% higher all-sites women, respectively, after adjustment age, body mass index, behavioral socioeconomic factors. When associations were evaluated site-specific...
Recent studies showing clear differences in the airway microbiota between healthy and diseased individuals shed light on importance of health. Here, we report associations host genetics lifestyles such as smoking, alcohol consumption, physical activity with composition sputum using 16S rRNA gene sequence data generated from 257 samples Korean twin-family cohort. By estimating heritability each microbial taxon, found that several taxa, including Providencia Bacteroides, were significantly...
Abstract ‘Healthy Twin’ is a twin family study extension of the existing Korean Twin-Family Register. Healthy Twin recruits adult like-sex twins over age 30 and their members. protocols are primarily tailored to quantitative trait loci complex traits as well role environment in etiology diseases. A full-length survey underway, including questionnaires, health examinations collection biological specimens. So far, 820 individuals (169 pairs families) have participated 1068 individual (608...
No consensus exists as to the most sensitive and specific obesity indicator associated with metabolic risk factors. We aimed validate anthropometry predictor for obesity‐related factors through comparison direct body composition measures in Korean adults. A total of 995 women 577 men who participated Healthy Twin study were subjects. Anthropometric measurements included BMI, waist circumference (WC), waist‐to‐hip ratio (WHR), waist‐to‐height (WHTR). Direct percentage fat (%BF) measured using...
Background and Purpose— The effect of smoking reduction on cardiovascular disease outcomes has not been studied in Asian populations. Methods— A total 475 734 Korean men aged 30 to 58 years, stratified into 9 groups based status at 2 different time points (1990 1992), were followed from 1992 2001 for the occurrence stroke or myocardial infarction (MI) events. Results— Compared with nonreducing heavy smokers (≥20 cigarettes/d), those who quit showed significantly lower risks ischemic stroke,...
The heritability of eating behavior and body weight–related traits in Asian populations has not been reported. purpose this study was to estimate the current weight self‐reported past among twins their families. Study subjects were 2,144 Korean, adult, same‐sex families at ages between 20 65 years (443 monozygotic (MZ) 124 dizygotic (DZ) twin pairs, 1,010 individuals family). Dutch Eating Behavior Questionnaire (DEBQ) used assess three subscales measuring restraint, emotional eating,...
Although diabetes is a well-known risk factor of atherosclerotic cardiovascular diseases, the disease glycemia below current diabetic threshold remains uncertain.A total 652,901 Korean men aged 30 to 64 years from National Health Insurance System were categorized into 8 groups by fasting blood glucose (FBG) level at baseline and followed up for diseases occurrence during 1992-2001. Over follow-up period 8.8 years, 10,954 stroke 3766 myocardial infarction events occurred. In age-adjusted...
Low-magnitude high-frequency (LMHF) vibrations have the ability to stimulate bone formation and reduce loss. However, anabolic mechanisms that are mediated by vibration in human cells at cellular level remain unclear. We hypothesized mesenchymal stromal (hMSCs) display direct osteoblastic responses LMHF signals. Daily exposure increased proliferation of hMSCs, with highest efficiency occurring a peak acceleration 0.3 g 30 40 Hz. Specifically, these conditions promoted osteoblast...
Determining valid zygosity is a basic and important requirement in twin study, because misdiagnosing leads to biased results. The Healthy Twin Study has collected data from adult like-sex twins their families since 2005. In the questionnaire determine was developed comprising four questions; one concerning degree of resemblance, three confusion by resemblance. Among 2,761 individuals (624 pairs) families, 406 pairs (mean age 38.3, 63.5% women) with both genotype information were selected...
For over 100 years, the genetics of human anthropometric traits has attracted scientific interest. In particular, height and body mass index (BMI, calculated as kg/m 2 ) have been under intensive genetic research. However, it is still largely unknown whether how heritability estimates vary between populations. Opportunities to address this question increased recently because establishment many new twin cohorts increasing accumulation data in established cohorts. We started a research project...
Human height variation is determined by genetic and environmental factors, but it remains unclear whether their influences differ across birth-year cohorts. We conducted an individual-based pooled analysis of 40 twin cohorts including 143,390 complete pairs born 1886–1994. Although variance showed a generally increasing trend the cohorts, heritability estimates (0.69-0.84 in men 0.53-0.78 women) did not present any clear pattern secular changes. Comparing geographic-cultural regions (Europe,...
Background: It is unclear if cigarette smoking and alcohol consumption are associated with thyroid cancer risk. Our aim was to explore for any associations between cancer, after adjusting potential confounders. Methods: Using data from the Korean National Health Insurance database, we retrospectively identified individuals aged ≥20 years who participated in 2009 health screening program were followed until 2017. We estimated adjusted hazard ratio (aHR) risk of using a Cox proportional model,...