A5062023106- Diabetes Management and Research
- Metabolism, Diabetes, and Cancer
- Diabetes and associated disorders
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Birth, Development, and Health
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Gestational Diabetes Research and Management
- Diet, Metabolism, and Disease
- Muscle metabolism and nutrition
- Adipokines, Inflammation, and Metabolic Diseases
- Pregnancy and preeclampsia studies
- Liver Disease Diagnosis and Treatment
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Genetic Associations and Epidemiology
- Obesity, Physical Activity, Diet
- Peroxisome Proliferator-Activated Receptors
- Muscle Physiology and Disorders
- Bone health and osteoporosis research
- Pharmacology and Obesity Treatment
- Regulation of Appetite and Obesity
- Cardiovascular Function and Risk Factors
- Assisted Reproductive Technology and Twin Pregnancy
Odense University Hospital
2015-2024
Steno Diabetes Centers
1995-2024
University of Southern Denmark
2009-2023
Capital Region of Denmark
2004-2018
Diabetes Australia
2018
Nordic Bioscience (Denmark)
2016
Danish Diabetes Academy
2015-2016
Institute of Clinical Research
2014
Endocrinology Research Center
2013
University of Eastern Finland
2013
A recent meta-analysis raised concern regarding an increased risk of myocardial infarction and death from cardiovascular causes associated with rosiglitazone treatment type 2 diabetes.We conducted unplanned interim analysis a randomized, multicenter, open-label, noninferiority trial involving 4447 patients diabetes who had inadequate glycemic control while receiving metformin or sulfonylurea, in which 2220 were assigned to receive add-on (rosiglitazone group), 2227 combination plus...
OBJECTIVE—The aim of this study was to compare pregnancy outcomes in type 1 diabetic pregnancies with the background population. RESEARCH DESIGN AND METHODS—This nationwide prospective multicenter took place eight Danish centers treating pregnant women diabetes during 1993–1999. A total 990 1,218 and delivery after 24 weeks (n = 1,215) or early termination due severe congenital malformations 3) were included. Data collected prospectively by one three caregivers each center reported a central...
The aim of this study was to evaluate the effect genetic variations in OCT1, OCT2, MATE1, MATE 2, and PMAT on trough steady-state plasma concentration metformin hemoglobin A1c (Hb1Ac).The South Danish Diabetes Study a 2 x factorial, prospective, randomized, double-blind, placebo-controlled, multicentre study. One hundred fifty-nine patients received 1 g metformin, twice daily continuously, 415 repeated measurements were obtained after 3, 6, 9 months treatment.The mean estimated be 576 ng/ml...
Evidence that age is associated with insulin resistance discordant. We analyzed euglycemic clamp (1 mU x min(-1) kg(-1)) data collected at 20 centers throughout Europe from 1,146 men and women normal glucose tolerance, ranging in 18 to 85 years. In the whole group, action (as M value) declined slightly (at a rate of 0.9 micromol min(-1)-kg(-1) per decade life, 95% CI = 0.4-1.3, P 0.0002). When adjusted for BMI, this relationship was no longer statistically significant. The same result...
Insulin resistance in non-insulin-dependent diabetes is associated with a defective insulin activation of the enzyme glycogen synthase skeletal muscles. To investigate whether this may be primary defect, we studied 20 young (25 +/- 1 yr) Caucasian first-degree relatives (children) patients diabetes, and matched controls without family history diabetes. Relatives had normal oral glucose tolerance, were by means euglycemic hyperinsulinemic clamp technique, which included performance indirect...
To gain further insight into the mechanisms underlying muscle insulin resistance, influence of obesity and type 2 diabetes on GLUT4 immunoreactivity in slow fast skeletal fibers was studied. Through a newly developed, very sensitive method using immunohistochemistry combined with morphometry, density found to be significantly higher compared biopsy specimens from lean obese subjects. In contrast, diabetic subjects, lower fibers. patients reduced by 9% weight-matched subjects 18% control...
Genetic and environmental factors contribute to age-dependent susceptibility type 2 diabetes. Recent studies have reported reduced expression of PPARγ coactivator 1α (PGC-1α) PGC-1β genes in skeletal muscle from diabetic patients, but it is not known whether this an inherited or acquired defect. To address question we studied these biopsies obtained young elderly dizygotic monozygotic twins without diabetes before after insulin stimulation related the a Gly482Ser variant PGC-1α gene. Insulin...
The purpose of this study was to investigate if insulin-dependent diabetes mellitus (IDDM) and non-insulin-dependent (NIDDM) predispose the development acute myocardial infarction (AMI) modify prognosis. includes 832 AMI patients consecutively hospitalized over a 3-yr period. prevalence among 9.7% is significantly higher than in an age-matched population, where it 6.1% (P less 0.001). for women men (14.9% versus 7.6%). risk found be twice as high IDDM nondiabetic Men with NIDDM were not have...
AimsThiazolidinediones are insulin sensitizers, and associated with fluid retention increased risk of heart failure (HF) in people type 2 diabetes. We assessed fatal non-fatal HF events their outcome, identified predictors the RECORD (Rosiglitazone Evaluated for Cardiac Outcomes Regulation glycaemia Diabetes) trial population.
OBJECTIVE To study the association between peri-conceptional A1C and serious adverse pregnancy outcome (congenital malformations perinatal mortality). RESEARCH DESIGN AND METHODS Prospective data were collected in 933 singleton pregnancies complicated by type 1 diabetes. RESULTS The risk of at different levels was compared with background population. significantly higher when exceeded 6.9%, tended to increase gradually increasing A1C. Women exceeding 10.4% had a very high 16%. Congenital...
12 identical twin pairs discordant for non-insulin-dependent diabetes mellitus (NIDDM) were studied insulin sensitivity (euglycemic clamp, 40 mU/m2 per min), hepatic glucose production (HGP, [3-3H]glucose infusion), and secretion (oral tolerance test hyperglycemic [12 mM] including glucagon administration). Five of the nondiabetic twins had normal seven impaired tolerance. 13 matched, healthy subjects without a family history included as control subjects. The NIDDM more obese compared with...
Glucose tolerance deteriorates with aging. To test whether age per se impairs basal beta-cell function, we analyzed retrospective clamp data from a large group (n = 957) of nondiabetic Europeans over the 18-85 yr range (the European Group for Study Insulin Resistance database). In this cohort, fasting posthepatic insulin delivery rate [IDR, obtained as product clamp-derived MCR and plasma concentration] was 8.9 (6.6) mU/min (median interquartile range), it gradually increased age. univariate...
Context: Insulin resistance (IR) and obesity, especially abdominal are regarded as central pathophysiological features of a cluster cardiovascular risk factors (CVRFs), but their relative roles remain undefined. Moreover, the differential impact IR viz. insulin response has not been evaluated. Objective: The objective this study was to dissect out IR/insulin on CVRF. Design: This cross-sectional study. Setting: conducted at 21 research centers in Europe. Subjects: included cohort 1308...
To determine whether activation by insulin of glycogen synthase (GS), phosphofructokinase (PFK), or pyruvate dehydrogenase (PDH) in skeletal muscle regulates intracellular glucose metabolism, subjects were studied basally and during euglycemic infusions 12, 30, 240 mU/m2 X min. Glucose disposal, oxidative nonoxidative metabolism determined. GS, PFK, PDH assayed under each condition. disposal rates 2.37 +/- 0.11, 3.15 0.19, 6.71 0.44, 11.7 1.73 mg/kg min; oxidation 1.96 0.18, 2.81 0.28, 4.43...
Abstract Objective: Indirect estimates of obesity such as BMI seem to be strongly influenced by genetic factors in twins. Precise measurements total and regional fat determined direct techniques DXA scan have only been applied a few twin studies. The aim the present study was estimate heritability (h 2 ) distribution young elderly Danish Research Methods Procedures: Monozygotic (108) dizygotic (88) twins two age groups (25 32 58 66 years) underwent anthropometric scans. Intraclass...
Physical exercise is known to improve glucose tolerance and diminish insulin requirements in patients with well-controlled diabetes mellitus. To ascertain whether these effects of are associated alterations receptors, we studied [125I]insulin binding erythrocytes monocytes athletically untrained young men insulin-treated during three hours postprandial bicycle (nine patients) two fasting (eight patients). Compared control periods, exercise, as well fasting, significantly increased at an...
Observational and mechanistic studies have suggested a possible relationship between treatment with metformin decreased incidence of cancer in participants type 2 diabetes. We extracted data for malignancies from the ADOPT (A Diabetes Outcome Progression Trial) RECORD (Rosiglitazone Evaluated Cardiovascular Outcomes Regulation Glycaemia Diabetes) randomised controlled clinical trials, which efficacy and/or safety was assessed comparison sulfonylureas rosiglitazone. Neoplasm occurrences were...