A5065714239- Gestational Diabetes Research and Management
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Growth Hormone and Insulin-like Growth Factors
- Bariatric Surgery and Outcomes
- Diabetes Management and Research
- Diet and metabolism studies
- Obesity, Physical Activity, Diet
- Ovarian function and disorders
- Breastfeeding Practices and Influences
- Diabetes Management and Education
- Obesity and Health Practices
- Reproductive Biology and Fertility
- Lipid metabolism and disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Diet, Metabolism, and Disease
- Sexual Differentiation and Disorders
- Sperm and Testicular Function
- Pituitary Gland Disorders and Treatments
- Metabolism, Diabetes, and Cancer
- Diabetes and associated disorders
- Muscle metabolism and nutrition
- Hormonal and reproductive studies
Aarhus University Hospital
2016-2025
Aarhus University
2015-2025
Steno Diabetes Centers
2021-2025
Odense University Hospital
2003-2020
University of Southern Denmark
2012-2020
Diabetes Care Center
2005
University of Copenhagen
2003-2005
Rigshospitalet
2003-2005
Glostrup Hospital
2003-2005
Aalborg University Hospital
2005
OBJECTIVE—The aim of this study was to compare pregnancy outcomes in type 1 diabetic pregnancies with the background population. RESEARCH DESIGN AND METHODS—This nationwide prospective multicenter took place eight Danish centers treating pregnant women diabetes during 1993–1999. A total 990 1,218 and delivery after 24 weeks (n = 1,215) or early termination due severe congenital malformations 3) were included. Data collected prospectively by one three caregivers each center reported a central...
In Brief OBJECTIVE: To estimate the association between maternal overweight and obesity on complications during pregnancy delivery in Denmark. METHODS: A population-based study a cohort consisting of all Danish women giving birth to singleton from 2004 through June 30, 2010 (N=403,092) was undertaken. Women were identified Medical Birth Registry, which contains data 99.8% deliveries Maternal fetal classified according International Classification Diseases, 10th Revision. RESULTS: The final...
OBJECTIVE To study the effects of lifestyle intervention on gestational weight gain (GWG) and obstetric outcomes. RESEARCH DESIGN AND METHODS The LiP (Lifestyle in Pregnancy) was a randomized controlled trial 360 obese women allocated early pregnancy to or control. program included dietary guidance, free membership fitness centers, physical training, personal coaching. RESULTS A total pregnant were included, 304 (84%) followed up until delivery. group had significantly lower median (range)...
OBJECTIVE To study the association between peri-conceptional A1C and serious adverse pregnancy outcome (congenital malformations perinatal mortality). RESEARCH DESIGN AND METHODS Prospective data were collected in 933 singleton pregnancies complicated by type 1 diabetes. RESULTS The risk of at different levels was compared with background population. significantly higher when exceeded 6.9%, tended to increase gradually increasing A1C. Women exceeding 10.4% had a very high 16%. Congenital...
Jørgensen JOL, Thuesen L, Müller J, Ovesen P, Skakkebæk NE, Christiansen JS. Three years of growth hormone treatment in hormone-deficient adults: near normalization body composition and physical performance. Eur J Endocrinol 1994;130:224–8. ISSN 0804–4643 Growth (GH) replacement therapy several controlled short-term trials have shown unanimous beneficial effects on other features. To evaluate more long-term we report data from 3 uninterrupted GH 10 GH-deficient adults who had all completed a...
To estimate the association between gestational diabetes mellitus (GDM) and adverse pregnancy neonatal outcomes in Denmark.A population-based cohort study including all singleton pregnancies Denmark from 2004 to 2010 (n = 403 092). Maternal complications during delivery fetal were classified according International Classification of Diseases 10th Revision.The final population consisted 398 623 women. Of these, 9014 (2.3%) had GDM. Data adjusted for maternal age, parity, smoking, birth...
To investigate the effect of gestational weight gain in obese glucose-tolerant women.We performed a historical cohort study 481 women with prepregnancy BMI > or = 30 kg/m2 and normal 2-h 75-g oral glucose tolerance test (OGTT) during third trimester (according to World Health Organization criteria). Data on OGTT results clinical outcomes were collected from medical records. Four groups defined according gain: group 1, <5.0 kg (n 93); 2, 5.0-9.9 134); 3, 10.0-14.9 132); 4, 15.0 122).Birth...
To audit stillbirth cases in women with type 1 diabetes to search for specific characteristics order improve antenatal care and treatment.Retrospectively identified of stillbirths during 1990-2000 were analyzed regarding the mother, pregnancy, glycemic control, stillborn. The cause was categorized as explainable, likely, or without obvious cause.We found 22 25 among 1,361 singleton births by diabetes. In seven explainable six likely. 12 no found; however, control suboptimal 9 these cases. A...
Many reports have suggested that hyperandrogenaemic patients with the polycystic ovary syndrome (PCOS) may be insulin resistant. However, there also been suggestions their resistance relate to obesity and android fat distribution. To assess whether PCOS induces metabolic disturbances independently of obesity, we studied seven lean (age, 27.1 +/- 2.0 yr; body mass index, 22.2 0.78 kg/m2; waist/hip ratio, 0.79 0.02; fat-free mass, 46.38 1.13 kg) normal women 25.7 1.4 21.3 0.69 0.74 50.1 1.51...
To study the effects of lifestyle intervention in pregnancy on weight retention 6 months postpartum among obese women from "Lifestyle Pregnancy" (LiP) study, and to determine associations between breastfeeding with maternal weight.Six follow up after a randomized controlled trial.Two university hospitals Denmark.A total 360 pregestational body mass index ≥30 kg/m(2) .The involved changes (diet exercise) during pregnancy. The control group received routine care. Both groups standard postnatal...
Carbohydrate is the macronutrient that has greatest impact on blood glucose response. Limited data are available how carbohydrate distribution throughout day affects in women with gestational diabetes mellitus (GDM). We aimed to assess a high-carbohydrate morning-intake (HCM) versus low-carbohydrate-morning-intake (LCM), affect glycemic variability and control. In this randomized crossover study continuous monitoring (CGM) was performed 12 diet treated GDM (75 g, 2-h OGTT ≥ 8.5 mmol/L), who...
Abstract Context Children of women with gestational diabetes (GDM) are often born a higher birthweight and have an increased risk overweight during childhood. High fetal growth rate is also associated being in Objective To examine excessive as mediator between GDM the offspring. Methods This was longitudinal cohort study, using routinely collected data on children 2008 2014 Aarhus, Denmark. Fetal biometrics were extracted from patient records at Aarhus University Hospital childhood weight...
The secretion of GH changes during the menstrual cycle, exhibiting high levels periovulatory phase (PO). Previous studies have not investigated whether this difference in status is due to increased or reduced clearance pituitary and amplified pulsatile vs. basal secretion. It also unclear PO accompanied by circulating insulin-like growth factor I (IGF-I). In study we 24-h release patterns early follicular (EF) same individuals. Ten young (aged 24-34 yr) healthy women with regular menses were...
Summary Objective Ghrelin and GH secretagogue receptors have been found in reproductive organs, including the placenta. The physiology of ghrelin pregnancy has not explored. In human pregnancy, pituitary is gradually replaced by placental (PGH). present study was undertaken to examine serum levels during normal determine what extent changes coincide with free total PGH. Design Prospective blood sampling from pregnant women gestational weeks 8, 18, 26 36 postpartum. Patients Eleven...
OBJECTIVE To study the association between microalbuminuria and development of preeclampsia preterm delivery in pregnant women with type 1 diabetes. RESEARCH DESIGN AND METHODS This was a population-based prospective 846 normoalbuminuric or microalbuminuric diabetes without antihypertensive treatment early pregnancy. Data were collected prospectively by one to three caregivers each center reported central registry. RESULTS The prevalence first trimester 10%, median duration 11 years,...
Maternal obesity and gestational weight gain are linked to offspring adverse metabolic profiles, lifestyle interventions during pregnancy in obese women may have long-term positive effects on their children. Furthermore, although the association between birth later outcomes is well established, little known about predictive value of abdominal circumference at birth. The purpose this study was determine (1) risk factors (2) values (BW) (BAC). This a follow-up randomized controlled trial,...
In nephrotic syndrome, plasminogen is aberrantly filtered from plasma to the urinary space and activated along tubular system. vitro, plasmin increases ENaC current by proteolytic cleavage of γ-subunit. It was hypothesized that preeclampsia associated with plasmin-dependent ability fluid activate ENaC. Urine sampled 16 preeclamptic (PE) patients 17 normotensive pregnant women (Ctrl). analyzed for plasmin(ogen), creatinine, albumin, aldosterone, Na(+), K(+), activity, its effect on inward in...
Objective In obese women, 1) to assess whether lower gestational weight gain (GWG) during pregnancy in the lifestyle intervention group of a randomized controlled trial (RCT) resulted differences offspring anthropometrics and body composition, 2) compare outcomes reference children born women with normal Body Mass Index (BMI). Research design methods The LiPO (Lifestyle Pregnancy Offspring) study was an follow-up RCT 360 pregnant including dietary advice, coaching exercise. completed by 301...