A5011580404- Birth, Development, and Health
- Assisted Reproductive Technology and Twin Pregnancy
- Genetics and Physical Performance
- Pregnancy and preeclampsia studies
- Inflammatory Bowel Disease
- Cognitive Abilities and Testing
- Genetic Associations and Epidemiology
- Obesity, Physical Activity, Diet
- Muscle Physiology and Disorders
- Sports Performance and Training
- Child and Adolescent Psychosocial and Emotional Development
- Adipose Tissue and Metabolism
- Prenatal Screening and Diagnostics
- Nutrition, Genetics, and Disease
- Carcinogens and Genotoxicity Assessment
- Immunodeficiency and Autoimmune Disorders
- Demographic Trends and Gender Preferences
- Cardiovascular Effects of Exercise
- Gestational Diabetes Research and Management
- Body Composition Measurement Techniques
- Microscopic Colitis
- Eosinophilic Esophagitis
- Human Health and Disease
- Celiac Disease Research and Management
- Renin-Angiotensin System Studies
KU Leuven
2014-2023
Kinokuniya
2019
Cambridge University Press
2019
New York University Press
2019
QIMR Berghofer Medical Research Institute
2019
Hospital Universitário da Universidade de São Paulo
2019
Maastricht University
2002-2011
Maastricht University Medical Centre
2011
Medisch Spectrum Twente
2011
Maastro Clinic
2009
Diagnostic value of anti- Saccharomyces cerevisiae and antineutrophil cytoplasmic autoantibodies in inflammatory bowel disease
Correct diagnosis of inflammatory bowel disease (IBD), especially the differentiation between Crohn's (CD) and ulcerative colitis (UC), is highly important toward treatment prognosis. Serological markers are noninvasive diagnostic tools that could be value in differentiating CD from UC, cases indeterminate colitis, identification subgroups IBD. The aim this study was to evaluate accuracy perinuclear antineutrophil cytoplasmic (pANCA) anti-Saccharomyces cerevisiae antibodies (ASCA) for...
BackgroundEvidence that a deficient innate immune response toward the bacterial flora of gut plays role in pathogenesis inflammatory bowel disease (IBD) is growing. This underscored by finding association between CARD15 variants and Crohn's (CD) D299G Toll-like receptor (TLR) 4 IBD. Our aims were to study nonsynonymous polymorphisms other TLR genes
S ummary An analysis of clinical, haematological, histological and cytogenetic data was performed in 85 consecutive patients with myelodysplastic syndromes (MDS). The criteria for diagnosis refractory anaemia (RA), acquired idiopathic sideroblas‐tic (AISA) chronic myelomonocytic leukaemia (CMML) were clearly defined, since the inclusion provided by FAB co‐operative group are imprecise. None these has received chemotherapy during follow‐up period. median survival whole only 15 months, less...
In January 1999, 500 tons of feed contaminated with approximately 50 kg polychlorinated biphenyls (PCBs) and 1 g dioxins were distributed to animal farms in Belgium, a lesser extent the Netherlands, France, Germany. This study was based on 20,491 samples collected database Belgian federal ministries from feed, cattle, pork, poultry, eggs, milk, various fat-containing food items analyzed for their PCB and/or dioxin content. Dioxin measurements showed clear predominance dibenzofuran over...
A study has been performed of 40 bone marrow trephine biopsies from patients with myelodysplastic syndromes (MDS). Histology, more specifically the abnormal localization immature precursors (ALIP), cytology and karyotype analysis were correlated survival time prognostic value these factors was determined. The presence or absence ALIP proved to be highly significant in predicting duration (P = 0.007): predisposes early death high probability developing acute myeloid leukaemia (AML), whereas...
The East Flanders Prospective Twin Survey (EFPTS), started in 1964, is unique among the 17 major European twin registers because it population based, twins (and higher order births) are ascertained at birth, basic perinatal data collected, chorion type established and, when appropriate, genetic markers including DNA fingerprints, determined. total number of sets 5089 twin, 158 triplet and 14 order. Zygosity has been diagnosed on basis sex, placental structure more than 95% pairs. EFPTS only...
Context: Genetic moderation of the depressioninducing effects stressful life events (SLEs) has been reported, but findings suggest that genes may not moderate SLEs per se instead risk depression associated with stable tendency to develop negative emotions in response minor environmental experiences.Objective: To examine whether a functional polymorphism serotonin transporter gene (5-HTTLPR) moderates association between affectivity (neuroticism) and what degree this can explain previous...
A bias to develop negative affect in response daily life stressors may be an important depression endophenotype, but remains difficult assess.To assess this mood uncontaminated by current mood, the course of life.The experience sampling method was used collect multiple appraisals event-related stress and 279 female twin pairs. Cross-twin, cross-trait associations between dailylife DSM-IV were conducted.Probands whose co-twins diagnosed with lifetime showed a stronger than those without such...
Abstract Objective Recently, Swedish members of the Epidemiological Investigation Rheumatoid Arthritis (EIRA) provided evidence that smoking may trigger RA‐specific immune reactions to citrullinated protein in carriers HLA–DR shared epitope alleles. In an effort confirm this interaction between and alleles, we performed a case‐only analysis 3 North American RA cohorts. Methods A total 2,476 white patients with were studied, 1,105 from Consortium (NARAC) family collection, 753 National...
Abstract Height variation is known to be determined by both genetic and environmental factors, but a systematic description of how their influences differ sex, age global regions lacking. We conducted an individual-based pooled analysis 45 twin cohorts from 20 countries, including 180,520 paired measurements at ages 1–19 years. The proportion height explained shared factors was greatest in early childhood, these effects remained present until adulthood. Accordingly, the relative contribution...
Objective: The negative affective response to daily life stressors, which previous work suggest is a fundamental depression endophenotype, may be moderated by positive emotions. It was investigated whether affect (PA) buffers (NA) reactivity in stress and PA moderates the genetic predisposition reactivity. Method: A total of 279 twin pairs participated momentary assessment study with experience sampling method, collecting appraisals flow life. Lifetime diagnoses were obtained. Results: There...
Abstract We investigated the heritability of educational attainment and how it differed between birth cohorts cultural–geographic regions. A classical twin design was applied to pooled data from 28 representing 16 countries including 193,518 twins with information on at 25 years age or older. Genetic factors explained major part individual differences in (heritability: a 2 = 0.43; 0.41–0.44), but also environmental variation shared by co-twins substantial (c 0.31; 0.30–0.33). The proportions...