A5088679649- Protease and Inhibitor Mechanisms
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Angiogenesis and VEGF in Cancer
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Blood Coagulation and Thrombosis Mechanisms
- Axon Guidance and Neuronal Signaling
- Cell Adhesion Molecules Research
- Signaling Pathways in Disease
- Corneal Surgery and Treatments
- S100 Proteins and Annexins
- Zebrafish Biomedical Research Applications
- Fish biology, ecology, and behavior
- Congenital heart defects research
- Neuropeptides and Animal Physiology
- Pregnancy and preeclampsia studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Neuroscience and Neuropharmacology Research
- Lymphatic System and Diseases
- Photoreceptor and optogenetics research
- Mitochondrial Function and Pathology
- Cancer, Hypoxia, and Metabolism
VIB-KU Leuven Center for Brain & Disease Research
2019-2025
KU Leuven
2015-2024
Allen Institute for Brain Science
2022-2024
Belgian Nuclear Research Centre
2021
VIB-KU Leuven Center for Cancer Biology
1996-2019
Zoological Institute
2016
Institute of Developmental Physiology
2015
Maastricht University
2015
Synapse (Netherlands)
2015
National Health Service
2015
The murine VEGF gene is alternatively transcribed to yield the VEGF120, VEGF164, and VEGF188 isoforms, which differ in their potential bind heparan sulfate neuropilin-1 stimulate endothelial growth. Here, role retinal vascular development was studied mice selectively expressing single isoforms. VEGF164/164 were normal, healthy, had normal angiogenesis. In contrast, VEGF120/120 exhibited severe defects outgrowth patterning, whereas VEGF188/188 displayed venular but impaired arterial...
Reactive astrocytes are thought to protect the penumbra during brain ischemia, but direct evidence has been lacking due absence of suitable experimental models. Previously, we generated mice deficient in two intermediate filament (IF) proteins, glial fibrillary acidic protein (GFAP) and vimentin, whose upregulation is hallmark reactive astrocytes. GFAP −/− Vim exhibit attenuated posttraumatic gliosis, improved integration neural grafts, regeneration. Seven days after middle cerebral artery...
Abstract Ovarian carcinomas have a poor prognosis, often associated with multifocal i.p. dissemination accompanied by intense neovascularization. To examine tumor angiogenesis in the microenvironment, we studied malignant ascites and tumors of patients untreated ovarian carcinoma. We observed that fluid induced potent vivo neovascularization Matrigel assay. detected sizable amount vascular endothelial cell growth factor (VEGF) ascites. However, pathologic concentration VEGF is insufficient...
Background Circumstantial evidence suggests that the plasminogen/plasmin system plays a role in many biological processes, including hemostasis, cell migration, and development. Methods Results The vivo function of was studied by generation plasminogen-deficient ( Plg −/− ) mice. Inactivation murine plasminogen gene achieved replacing, via homologous recombination embryonic stem cells, genomic sequences encoding exons containing catalytic site amino acids His 605 Asp 648 with neomycin...
Abstract Microglia play an important role in the pathology of CNS disorders, however, there remains significant uncertainty about neuroprotective/degenerative these cells due to a lack techniques adequately assess their complex behaviour response injury. Advancing microscopy techniques, transgenic lines and well-characterized molecular markers, have made histological assessment microglia populations more accessible. However, is distinct tools extract information from images fully...
The murine VEGF gene is alternatively transcribed to yield the VEGF120, VEGF164, and VEGF188 isoforms, which differ in their potential bind heparan sulfate neuropilin-1 stimulate endothelial growth. Here, role retinal vascular development was studied mice selectively expressing single isoforms. VEGF164/164 were normal, healthy, had normal angiogenesis. In contrast, VEGF120/120 exhibited severe defects outgrowth patterning, whereas VEGF188/188 displayed venular but impaired arterial...
Epidemiological and histological evidence implicates proteinases of the matrix metalloproteinase (MMP) family in atherosclerosis aneurysm formation. We previously indicated a role for urokinase-type plasminogen activator atherosclerotic media destruction by proteolytic activation MMPs. However, specific MMPs, such as MMP-9 MMP-12, remains undefined.MMP-9- or MMP-12-deficient mice were crossed atherosclerosis-prone apolipoprotein E-deficient background fed cholesterol-rich diet. Mice killed...