A5041622839- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Neurogenesis and neuroplasticity mechanisms
- Pharmacological Effects of Natural Compounds
- Neuroendocrine regulation and behavior
- Neurological Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Alkaloids: synthesis and pharmacology
- Natural product bioactivities and synthesis
- Ear Surgery and Otitis Media
- Nerve injury and regeneration
- Neurotransmitter Receptor Influence on Behavior
- Autism Spectrum Disorder Research
- Cholinesterase and Neurodegenerative Diseases
- Otitis Media and Relapsing Polychondritis
- GABA and Rice Research
- Retinal Development and Disorders
- Olfactory and Sensory Function Studies
- Folate and B Vitamins Research
- Gastrointestinal motility and disorders
- Immune Response and Inflammation
- Biochemical effects in animals
- Epigenetics and DNA Methylation
- Nuclear Receptors and Signaling
Setsunan University
2015-2024
University of Yamanashi
2024
Takeda (Japan)
2024
Yamanashi Gakuin University
2024
Pharmac
2020-2022
Kitasato University
2003-2012
Kitasato Institute Hospital
2000-2010
National Institutes of Health
2000-2007
National Institute of Neurological Disorders and Stroke
2000-2007
United States Department of Health and Human Services
2005
Reactive astrocytes are thought to protect the penumbra during brain ischemia, but direct evidence has been lacking due absence of suitable experimental models. Previously, we generated mice deficient in two intermediate filament (IF) proteins, glial fibrillary acidic protein (GFAP) and vimentin, whose upregulation is hallmark reactive astrocytes. GFAP −/− Vim exhibit attenuated posttraumatic gliosis, improved integration neural grafts, regeneration. Seven days after middle cerebral artery...
Pigment epithelium-derived factor (PEDF) protects immature cerebellar granule cells (1–3 days in vitro) against induced apoptosis and mature (5+ glutamate toxicity, but its precise mechanism is still unknown. Because the transcription NFκB blocks cell death, including neuronal apoptosis, we have investigated ability of PEDF to exert effects via activation. an increased phosphorylation IκBα, decreased levels IκB proteins, translocation p65 (RelA) nucleus followed by a time-dependent increase...
Rosmarinic acid (RA) is one of major polyphenolic ingredients Perillae Herba (a leaf Perilla frutescens), and has an antidepressant-like property in animal models depression. However, the mechanism(s) underlying this activity are unknown. Recent studies have reported that regulation hippocampal neurogenesis associated with pathogenesis To elucidate mode action RA-induced activity, proliferative effect RA on newborn cells dentate gyrus mouse hippocampus was investigated using...
The bone morphogenetic proteins (BMPs) play an inductive role in the generation of cerebellar granule cells embryonically. Therefore, we chose to look at their effects on cell survival and differentiation postnatally. express mRNA for both BMP-6 BMP-7, as well receptors BMPRIA BMPRII, demonstrating that postnatal have ability form heterodimer needed respond BMPs. BMP-7 promotes survival, with a maximal effect 10 ng/ml, whereas tenfold more is needed: Both were active over course 8 days...
Background Although patients with intractable otitis media associated bronchial asthma have extensive accumulation of eosinophils in the middle ear mucosa and effusion, systematic histological immunohistochemical studies not been performed. Objectives To clarify pathogenesis diseases, we carried out on specimens, particularly focusing characteristics accumulated eosinophils. Methods Middle specimens obtained from eight adult 17 controls were immunohistochemically stained using monoclonal...
Pigment epithelium-derived factor (PEDF) is a potent and broadly acting neurotrophic that protects neurons in various types of cultured against glutamate excitotoxicity induced-apoptosis. Some the effects PEDF reflect specific changes gene expression, mediated via activation transcription NF-κB neurons. To investigate whether also modulates expression astrocytes, we employed use RT-PCR to analyze certain pro-inflammatory genes found such as IL-1β, IL-6, TNF-α, MIP1α, MIP3α were induced...
Kososan, a Kampo (Japanese herbal) medicine, has an antidepressive-like effect in behavioral animal models of depression and been used clinically for the improvement depressive mood. However, mechanism(s) underlying kososan remain unknown. Previous studies showed that orexin-A (OX-A), neuropeptide is involved feeding arousal, exhibits property via hippocampal cell proliferation. Here, we immunohistochemical analysis with bromodeoxyuridine (BrdU), marker proliferating cells, to investigate...
Emotional impairments such as depressive symptoms often develop in patients with sustained and systemic immune activation. The objective of this study is to investigate the effect gomisin N, a dibenzocyclooctadiene lignan isolated from dried fruits Schisandra chinensis (Turcz.) Baill., which exhibited inhibitory effects bacterial endotoxin lipopolysaccharide (LPS)-induced NO production screening assay, on inflammation-induced symptoms. We examined N inflammation induced by LPS murine...
6-hydroxydopamine (6-OHDA) lesion of the substantia nigra (SN) causes appearance reactive astrocytes not only in SN but also striatal terminal fields, as measured by increased size cells and their processes, well enhanced expression glial fibrillary acidic protein (GFAP) an epitope recognized monoclonal antibody 19D1. We now demonstrate that polysialylated neural cell adhesion molecule (PSA-NCAM) is induced on astrocytes, large neurons, ipsilateral side 6-OHDA-lesioned SN. Colocalization...
Pigment epithelium-derived factor (PEDF) is a 50-kDa glycoprotein that protects various types of cultured neurons against neurotoxic stimuli, but its precise role in the CNS not fully understood. In this study, we used rats whose brains were transfected to over-express human PEDF order elucidate neuroprotective effect following transient middle cerebral artery occlusion (MCAO). A replication-defective adenoviral vector containing gene (Ad.PEDF) or E. colibeta-galactosidase (Ad.LacZ) was...