A5056647440- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Mitochondrial Function and Pathology
- Marine Biology and Environmental Chemistry
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Tea Polyphenols and Effects
- Environmental Toxicology and Ecotoxicology
- Amino Acid Enzymes and Metabolism
- Organometallic Compounds Synthesis and Characterization
- IL-33, ST2, and ILC Pathways
- RNA Interference and Gene Delivery
- Neurogenesis and neuroplasticity mechanisms
- Polyamine Metabolism and Applications
- Nicotinic Acetylcholine Receptors Study
- Chemical Synthesis and Analysis
- Genomics and Chromatin Dynamics
- Apelin-related biomedical research
- Receptor Mechanisms and Signaling
- bioluminescence and chemiluminescence research
- RNA regulation and disease
- Olfactory and Sensory Function Studies
- Metabolism, Diabetes, and Cancer
- Nuclear Receptors and Signaling
- Chemical Reactions and Isotopes
Setsunan University
2015-2024
Pharmac
2019-2022
Laboratory of Molecular Genetics
2019
Kyoto University
2017
Kumamoto University
2017
University of Pennsylvania
2005-2007
Kanazawa University
2000-2006
Kyoto Prefectural University of Medicine
2000
Technology Research Institute of Osaka Prefecture
1993
Abstract The vitamin D receptor (VDR) is believed to mediate different biologic actions of 3 , an active metabolite D, through regulation gene expression after binding specific DNA‐response element (VDRE) on target genes. To further understand roles both and VDR in the central nervous system, we examined VDRE nuclear extracts prepared from discrete rat brain regions cultured cortical neurons by electrophoretic mobility shift assay. highest activity was found cerebellum among other examined,...
Abstract L-theanine, an amino acid component of the tea leaves Camellia sinensis , is sold in Japan as a supplement for good sleep. Although several studies humans and mice have reported effects L-theanine on brain function, only few reports comprehensively clarified disposition theanine administered to its concentrations other blood acids. In this study, we aimed determine changes levels composition serum. were four-week-old Std-ddY male orally or via tail vein injection. acids serum...
Abstract A 72-year-old woman had suffered from parapsoriasis en plaque (large type) controlled by topically applied psoralen ultraviolet (PUVA) therapy. The lesions gradually disappeared, but numerous tiny red papules with pruritus appeared over the forearms and lower legs 120 days after starting PUVA These developed to form violaceous plaques. Histological findings demonstrated characteristics of lichen planus. Two months later, tense bullae on plaques uninvolved skin limbs. were...
Rat cortical neurons cultured for 3 days in vitro were loaded with the fluorescent indicator fluo-3 assessment of intracellular free calcium ion (Ca2+) concentrations aid a confocal laser-scanning microscope. In absence added MgCl2, addition NMDA induced rapid but sustained increase number concentration-dependent manner at concentration range 1-100 micro m by KCl being transient. The FeCl2, not FeCl3, markedly inhibited reversible 10-200 m, without affecting that KCl. Extensive analyses...
The organotin trimethyltin (TMT) is well known to cause neuronal degeneration in the hippocampal dentate gyrus of mice. first purpose present study was examine whether cyclooxygenase (COX) inhibitor indomethacin could ameliorate mice following TMT treatment vivo. systemic injection into at 2.8 mg/kg produced activation endogenous caspase-3 and calpain, enhanced gene expression COX-1 COX-2, activated microglial cells, caused formation lipid peroxidation product 4-hydroxynonenal hippocampus....
Metabotropic glutamate receptors (mGluRs) are a class of G-protein-coupled that possess seven transmembrane region involved in the modulation excitatory synaptic transmission nervous system. mGluR orthologs have been identified Drosophila, Caenorhabditis elegans, and higher organisms. Drosophila possesses two genes, DmGluRA DmXR. We screened Dictyostelium genome data base using ligand binding domain rat mGluR1 as bait, new receptor, DdmGluPR, belonging to family. Similar DmXR, residues...
Abstract The organotin trimethyltin (TMT) is well known to cause neuronal damage in the central nervous system. To elucidate mechanisms underlying toxicity of TMT toward neurons, we prepared primary cultures neurons from neocortex mouse embryos. A continuous exposure produced a decrease cell viability as an increase number cells with nuclear condensation/shrinkage at time window up 24 hr. In addition events early window, lactate dehydrogenase released was significantly elevated later 36 48...
This study evaluates the pathological role of stress sensor activating transcription factor-3 (ATF3) in ischemic neurotoxicity. Upregulation transcript and protein for ATF3 was seen 2-10 hr after reperfusion ipsilateral cerebral hemisphere mice with transient middle artery occlusion 2 hr. Immunohistochemical analysis confirmed expression by cells immunoreactive a neuronal marker neocortex, hippocampus, striatum within reperfusion. In murine neocortical neurons previously cultured under...
Abstract Cortical primary cultures were loaded with the fluorescent indicator fluo‐3 for assessment of intracellular‐free Ca 2+ ions aid a confocal laser‐scanning microscope. The addition N ‐methyl‐ D ‐aspartic acid (NMDA) markedly increased number cells in manner sensitive to prevention by both an NMDA channel blocker and MgCl 2 . In absence added , induced sustained increase transient KCl cultured 3 days vitro (DIV). Both nifedipine dantrolene more potent preventing cortical preparations 9...
This study investigated the time course of dynamics lymphocyte subsets in peripheral blood mice, after bilateral lesions were made at anterior, middle and posterior sites hypothalamus using a stereotaxic technique. Lymphocyte analyzed by monoclonal antibodies specific to cell surface markers laser flow cytometry system. The results indicate that anterior parts seem play role immunomodulation both helper suppressor T lymphocytes. part is considered be site control mechanism immune regulation B