A5005404495- Neuroscience and Neuropharmacology Research
- Amino Acid Enzymes and Metabolism
- Ion channel regulation and function
- Molecular Sensors and Ion Detection
- Bone Metabolism and Diseases
- Chemical Synthesis and Analysis
- Catalysis and Oxidation Reactions
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Receptor Mechanisms and Signaling
- Catalytic Processes in Materials Science
- Biochemical effects in animals
- Polyamine Metabolism and Applications
- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- Anesthesia and Neurotoxicity Research
- Zeolite Catalysis and Synthesis
- Polyoxometalates: Synthesis and Applications
- Tryptophan and brain disorders
- RNA Interference and Gene Delivery
- Inorganic and Organometallic Chemistry
- MicroRNA in disease regulation
- Genetics and Neurodevelopmental Disorders
- Photoreceptor and optogenetics research
- RNA Research and Splicing
Setsunan University
1991-2022
Institute of Experimental Pharmacology and Toxicology of the Slovak Academy of Sciences
2022
Osaka University
2019-2021
Kanazawa University
2011-2020
Osaka Medical and Pharmaceutical University
2000-2008
University of Bonn
2006
Osaka City General Hospital
2003
Osaka City University
1987-2003
Doshisha Women's College of Liberal Arts
2001
Tokai University
1993-1996
Abstract The fundamental properties of 12-heteropolyacids Mo and W, such as the structure, surface area, acidity, reduction-oxidation mechanism, have been studied in their solid state relation to heterogeneous catalysis. primary structure (heteropolyanion) was rather stable, but secondary very variable according interaction with various molecules, like water, alcohols, ketones, pyridine. This structural characteristic is important for understanding catalysis these compounds; it may be called...
Abstract Experiences during brain development may influence the pathogenesis of developmental disorders. Thus, social isolation (SI) rearing after weaning is a useful animal model for studying pathological mechanisms such psychiatric diseases. In this study, we examined effect SI on neurogenesis in hippocampal dentate gyrus (DG) relating to memory and emotion‐related behaviors. When newly divided cells were labeled with 5‐bromo‐2′‐deoxyuridine (BrdU) before SI, number BrdU‐positive rate...
ABSTRACT Global gene deletion studies in mice and humans have established the pivotal role of runt related transcription factor-2 (Runx2) both intramembranous endochondral ossification processes during skeletogenesis. In this study, we for first time generated carrying a conditional Runx2 allele with exon 4, which encodes Runt domain, flanked by loxP sites. These were crossed α1(I)-collagen-Cre or α1(II)-collagen-Cre transgenic to obtain osteoblast-specific chondrocyte-specific deficient...
Nrf2 (nuclear factor E2 p45-related 2) is believed to be a transcription essential for the regulation of many detoxifying and antioxidative genes in different tissues. In present study, we investigated role osteoblastic differentiation. <i>nrf2</i> mRNA expression was significantly up-regulated femur isolated from ovariectomized mice, whereas <i>in situ</i> hybridization analysis revealed that up-regulation mainly found osteoblasts attached on cancellous bone mice. Expression protein also...
J. Neurochem. (2010) 114 , 1840–1851. Abstract Neurogenesis in the hippocampus occurs throughout life a wide range of species and could be associated with hippocampus‐dependent learning memory. Stress is well established to seriously perturb physiological/psychological homeostasis affect hippocampal function. In present study, investigate effect chronic restraint stress early on neurogenesis memory, 3‐week‐old mice were subjected 6 days week for 4 weeks. The significantly decreased volume by...
Circadian rhythm disturbances are well established in neurological diseases. However, how these disruptions cause homeostatic imbalances remains poorly understood. Brain and muscle aryl hydrocarbon receptor nuclear translocator-like protein 1 (Bmal1) is a major circadian clock transcriptional activator, Bmal1 deficiency male Bmal1nestin-/- mice induced marked astroglial activation without affecting the number of astrocytes brain spinal cord. deletion caused blood-brain barrier (BBB)...
ABSTRACT We have previously shown that endochondral ossification is finely regulated by the Clock system expressed in chondrocytes during postnatal skeletogenesis. Here we show a sophisticated modulation of bone resorption and mass through its expression bone-forming osteoblasts. Brain muscle aryl hydrocarbon receptor nuclear translocator-like protein 1 (Bmal1) Period1 (Per1) were with oscillatory rhythmicity vivo, circadian rhythm was also observed cultured osteoblasts Per1::luciferase...
Abstract The vitamin D receptor (VDR) is believed to mediate different biologic actions of 3 , an active metabolite D, through regulation gene expression after binding specific DNA‐response element (VDRE) on target genes. To further understand roles both and VDR in the central nervous system, we examined VDRE nuclear extracts prepared from discrete rat brain regions cultured cortical neurons by electrophoretic mobility shift assay. highest activity was found cerebellum among other examined,...
Abstract The reactivity and related properties of oxygen both in the bulk on surface has been investigated for perovskite-type mixed oxides (La1−xSrxCoO3), regard to effects Sr2+-substitution calcination temperature. reducibility readiness desorption increased with Sr2+ content, x, but re-oxidation became slower x. These results have explained basis change chemical potential lattice oxygen. diffusivity ability activate molecule also Oxygen vacancies surface, which tended increase are likely...
Runt-related transcription factor 2 (Runx2) is an essential transcriptional regulator of osteoblast differentiation and its haploinsufficiency leads to cleidocranial dysplasia because a defect in during bone formation through intramembranous ossification. The cellular origin period for Runx2 function ossification remain poorly understood. Paired related homeobox 1 (Prx1) expressed craniofacial mesenchyme, deficiency Prx1+-derived cells (Runx2prx1−/− mice) resulted defective was...
Abstract Runx2 may play an important role in development of osteoarthritis (OA). However, the specific articular chondrocyte function and OA adult mice has not been fully defined. In this study, we performed destabilization medial meniscus (DMM) surgery at 12-week-old to induce Agc1CreER mice, which was specifically deleted Aggrecan -expressing chondrocytes by administering tamoxifen 8-weeks age. Knee joint samples were collected 8- 12-weeks post-surgery analyzed through histology,...
Although naturally occurring polyamines are indispensable for a variety of cellular events in eukaryotic cells, little attention has been paid to their physiological and pathological significance bone remodelling date. In this study, we evaluated the pharmacological properties several natural on functionality integrity both vitro vivo experiments.Mice were subjected ovariectomy (OVX) subsequent oral supplementation with either spermidine or spermine determination volume together different...